UniProtKB - A0A0A1EII5 (A0A0A1EII5_HUMAN)
Protein
Submitted name:
Forkhead box protein E3
Gene
FOXE3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 71 – 165 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- cell development Source: Ensembl
- ciliary body morphogenesis Source: Ensembl
- cornea development in camera-type eye Source: Ensembl
- iris morphogenesis Source: Ensembl
- lens development in camera-type eye Source: Ensembl
- negative regulation of lens fiber cell differentiation Source: Ensembl
- positive regulation of lens epithelial cell proliferation Source: Ensembl
- trabecular meshwork development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box protein E3Imported |
Gene namesi | Name:FOXE3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186790.5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000186790, Expressed in mucosa of transverse colon and 29 other tissues |
ExpressionAtlasi | A0A0A1EII5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 165 | Fork-headInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 69 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 35 | Pro-richSequence analysisAdd BLAST | 15 |
Phylogenomic databases
HOGENOMi | CLU_023357_0_1_1 |
OMAi | PEPPCCA |
OrthoDBi | 1270467at2759 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A0A1EII5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGRSDMDPP AAFSGFPALP AVAPSGPPPS PLAGAEPGRE PEEAAAGRGE
60 70 80 90 100
AAPTPAPGPG RRRRRPLQRG KPPYSYIALI AMALAHAPGR RLTLAAIYRF
110 120 130 140 150
ITERFAFYRD SPRKWQNSIR HNLTLNDCFV KVPREPGNPG KGNYWTLDPA
160 170 180 190 200
AADMFDNGSF LRRRKRFKRA ELPAHAAAAP GPPLPFPYAP YAPAPGPALL
210 220 230 240 250
VPPPSAGPGP SPPARLFSVD SLVNLQPELA GLGAPEPPCC AAPDAAAAAF
260 270 280 290 300
PPCAAAASPP LYSQVPDRLV LPATRPGPGP LPAEPLLALA GPAAALGPLS
310
PGEAYLRQPG FASGLERYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KM433708 mRNA Translation: AIY30327.1 KU342020 Genomic DNA Translation: AMM45327.1 KU342021 Genomic DNA Translation: AMM45328.1 KU342022 Genomic DNA Translation: AMM45329.1 |
RefSeqi | NP_036318.1, NM_012186.2 |
Genome annotation databases
GeneIDi | 2301 |
KEGGi | hsa:2301 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KM433708 mRNA Translation: AIY30327.1 KU342020 Genomic DNA Translation: AMM45327.1 KU342021 Genomic DNA Translation: AMM45328.1 KU342022 Genomic DNA Translation: AMM45329.1 |
RefSeqi | NP_036318.1, NM_012186.2 |
3D structure databases
SMRi | A0A0A1EII5 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 18909, 204 antibodies |
Genome annotation databases
GeneIDi | 2301 |
KEGGi | hsa:2301 |
Organism-specific databases
CTDi | 2301 |
EuPathDBi | HostDB:ENSG00000186790.5 |
Phylogenomic databases
HOGENOMi | CLU_023357_0_1_1 |
OMAi | PEPPCCA |
OrthoDBi | 1270467at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2301, 4 hits in 864 CRISPR screens |
GenomeRNAii | 2301 |
Gene expression databases
Bgeei | ENSG00000186790, Expressed in mucosa of transverse colon and 29 other tissues |
ExpressionAtlasi | A0A0A1EII5, baseline and differential |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A1EII5_HUMAN | |
Accessioni | A0A0A1EII5Primary (citable) accession number: A0A0A1EII5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 4, 2015 |
Last sequence update: | February 4, 2015 | |
Last modified: | December 2, 2020 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |