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Protein
Submitted name:

Polyketide synthase

Gene

M271_31610

Organism
Streptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994) (Streptomyces hygroscopicus (strain ATCC 29253))
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Polyketide synthaseImported
Gene namesi
ORF Names:M271_31610Imported
OrganismiStreptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994) (Streptomyces hygroscopicus (strain ATCC 29253))Imported
Taxonomic identifieri1343740 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000030183 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1538O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3298O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5136O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1503 – 1578CarrierInterPro annotationAdd BLAST76
Domaini3263 – 3338CarrierInterPro annotationAdd BLAST76
Domaini5101 – 5176CarrierInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 31Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.40.366.10, 3 hits
3.40.47.10, 3 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR015083 Polyketide_synth_docking
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 3 hits
PF08990 Docking, 1 hit
PF16197 KAsynt_C_assoc, 3 hits
PF00109 ketoacyl-synt, 3 hits
PF02801 Ketoacyl-synt_C, 3 hits
PF08659 KR, 3 hits
PF00550 PP-binding, 3 hits
PF14765 PS-DH, 2 hits
SMARTiView protein in SMART
SM00827 PKS_AT, 3 hits
SM00826 PKS_DH, 2 hits
SM00825 PKS_KS, 3 hits
SM00823 PKS_PP, 3 hits
SUPFAMiSSF47336 SSF47336, 3 hits
SSF51735 SSF51735, 6 hits
SSF52151 SSF52151, 3 hits
SSF53901 SSF53901, 3 hits
SSF55048 SSF55048, 3 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 3 hits
PS50075 CARRIER, 3 hits
PS00012 PHOSPHOPANTETHEINE, 3 hits

Sequencei

Sequence statusi: Complete.

A0A0A0NSU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANEETLRDY LKLVTADLHQ TRLRLQEAEA KNHDPIAIVG IGCRYPGGVS
60 70 80 90 100
SPEDLWRIVS EGVDAVSEFP LDRGWNVDTM YHPDPDHPGT SYVHEGGFVD
110 120 130 140 150
GIADFDPSLF GISPREALGM DPQQRMLLET SWEAFERAGI DPVAVRGRQI
160 170 180 190 200
GVFVGTSNHD YLGAILSSNE NFEGYFGTGN AASVASGRLS YTFGFEGPAV
210 220 230 240 250
TVDTACSSSL VALHLAVQAL RNGECSLALA GGATLMCAPG VFVDYSKMRG
260 270 280 290 300
LALDGRSKPF APEADGFCLG EGVGMLLVER LSDAQRKGHP VLAVVRGSAV
310 320 330 340 350
NQDGASNGLT SPNGPSQQRV ILQALANARL TPDQVDAVEA HGTGTALGDP
360 370 380 390 400
IEAQALLATY GQDRPEGKPL LIGSIKSNIG HAQAGAGVGG IIKMVMAMRH
410 420 430 440 450
GVLPQTLHLT EPTPHVDWTA GDVELLTAPR EWGKDPEGAT PRRAGVSSFG
460 470 480 490 500
MSGTNVHTIL EEAPALAAPA ESGEDGKPER AEMPLVPVVL SGKNEQALRA
510 520 530 540 550
QALRLRTHLA THPGHRLADI GYSQAATRAA LDRRAAVVAA GHDELLAGLD
560 570 580 590 600
ALAEGRHHPE VAEGLAAEGK VAFLFTGQGS QRLGMGRELY ATYPVFAEAL
610 620 630 640 650
DAVCAQLDRF LDRPLKDVLF GDDAATLDRT GYTQPALFAV EVALFRLVES
660 670 680 690 700
WGLRPDFLSG HSIGELTAAH VAGVLSLTHA SALVAARSQL MQQLPTGGAM
710 720 730 740 750
IAVQAAEDEV TPLLTERVSI AAINGPTSVV IAGDEGAALE IAAGFEAQGR
760 770 780 790 800
KTKRLTVSHA FHSPHMDGML ANFRQVAERL TYEAPKIPIV SNLTGTLVSA
810 820 830 840 850
DEITTPEFWV RHVREAVRFL DGVRRLEDHG VTTYLELGPD GVLSAMAQEC
860 870 880 890 900
VSGDRNRTFA FLPALRPGRP EPRTLSNALA QAHVRGLPVD WATYYAGTGA
910 920 930 940 950
RRVELPTYAF QRQRYWPANP FSYGVDSAAA EAAAPAVADA RFWEVVHSED
960 970 980 990 1000
LPALVETLGL DGDQPLSEVL PVLSAWRRQS HVDTTVDRWR YRVTWTPLPQ
1010 1020 1030 1040 1050
TPDKPLTGTW LVVTPEGHAD DPWVAEPLRL LAERGVTVHR IDVDGATADR
1060 1070 1080 1090 1100
TALAERIRTA LSPDPALQAP SFDGVLSLLG LDERPHDRHP SLTAGLAGTL
1110 1120 1130 1140 1150
TLVQALGDAD LDAPLWAATR GAVSVGRSDR LTSPEQAQIW GLGRTAALEH
1160 1170 1180 1190 1200
PERWGGLIDL PETADDRALG RLADILAGPD GISGEDHLAI RPQGIHARRL
1210 1220 1230 1240 1250
ARAPHHETTD DGWTTHGTAL ITGGTGALGG HVARWLVAHG AQHILLTGRR
1260 1270 1280 1290 1300
GPDAPGAAEL RDELTALGAQ VTVAACDVAD RGALAGLLAT VPADLPLTTV
1310 1320 1330 1340 1350
VHAAGVLDDG VLDAQTPRRM ADVLRAKADS ARHLHELTRG LDLSAFVLFS
1360 1370 1380 1390 1400
SMAATFGAAG QANYVAANAY LDALAEQRRA EGLPATSMAW GAWADGGMAT
1410 1420 1430 1440 1450
DELVAERLRQ SGLPALATGP ATAALGAALD LDETFSLVVD IEWNRFAPGL
1460 1470 1480 1490 1500
AGHRPNPLLA DLSEAKRAIE VARTATGGPA IPGRPTSPAQ RLTDAGTDEE
1510 1520 1530 1540 1550
RDQIALDFVR TQVAVVLGHP GPDSVEPSRA FRDLGFDSLT AVEIRNLLAT
1560 1570 1580 1590 1600
LTGLKLPATI IFDYPTPIAL ADHLKAELIG SRPAVPGASS VGVALDDDPI
1610 1620 1630 1640 1650
AIVGMSCRFP GGVRSPEELW RLLASGQDAV VDFPADRGWD LETLYDPEGT
1660 1670 1680 1690 1700
GEHTSYVREG GFLADAAEFD PVFFGISPRE ALAMDPQQRM LLETSWEAFE
1710 1720 1730 1740 1750
RAGIDPTTLR GQQVGVFAGT NGQDYLPVIL SAPDGSEGFM GTGNAASVMS
1760 1770 1780 1790 1800
GRVSYALGLE GPAVTVDTAC SSSLVALHWA IQALRAGECS LALAGGVTVM
1810 1820 1830 1840 1850
STPGSFVDFS RQRGLAADGR IKAFAAGADG TGWGEGVGML LVERLSDARR
1860 1870 1880 1890 1900
NGHEVLAVVR GSAINQDGAS NGLTAPNGPS QQRVIRQALA GAGLSASEVD
1910 1920 1930 1940 1950
AVEAHGTGTK LGDPIEAQAL LATYGQERDA EQPLWLGSIK SNFGHTQAAA
1960 1970 1980 1990 2000
GVAGVMKMVL AIQHGLLPQT LNVDEPTPHV DWSAGAVSLL TEAREWPETG
2010 2020 2030 2040 2050
RPRRAAVSSF GISGTNAHTI IEQAPVYADE TEDTAPVAAP RSGLPATWML
2060 2070 2080 2090 2100
SAKSPEGLRD QAVRLRAHLD ERPELDLTDV AFTLATRRTA FEERAALVAE
2110 2120 2130 2140 2150
DRDGLLSGLA ALAEGRTAAG LAQGSVAGGK VAFLFTGQGS QRLGMGRELY
2160 2170 2180 2190 2200
DAFPVFADAL DEVCAHLDGH LERPLREVLF GDDAEALDQT GFTQPALFAV
2210 2220 2230 2240 2250
EVALFRLVSE AWGLKADFLS GHSIGELAAA HVAGVLSLAD AAKLVAARGR
2260 2270 2280 2290 2300
LMQELPAGGA MIALQASEDE VAPLLTERVS IAALNGPTSV VIAGDEDAAL
2310 2320 2330 2340 2350
EIASGFEARG RKTKRLTVSH AFHSPRMDGM LDAFREVAEG LSYEAPRIPI
2360 2370 2380 2390 2400
VSNLTGAVAS AEEIATADFW VRHVREAVRF LDGVRTLEAQ GVTTYVELGP
2410 2420 2430 2440 2450
DGVLTAMAQE CVTDPDVAGF AAVLRKDRPE AEALLSAVAR AHVRGVAVDW
2460 2470 2480 2490 2500
AAYYARTGAA QVALPTYAFQ RQRYWPKVSS LFLGDVAAVG LGEAGHPLLG
2510 2520 2530 2540 2550
ASAELPDADA TLFTGRLALS THPWLAGHTI MDTVLLPGTA FVELAIRAGD
2560 2570 2580 2590 2600
QVGCDYLEEL TLEAPLVLPA QGGVQLRLSV GAADETGRRP LSLHSRLESL
2610 2620 2630 2640 2650
PAEEPWTRHA AGVLASGGRP EASFELSAWP PADAAEVELD GRYEGLLDIG
2660 2670 2680 2690 2700
FAYGPAFQGL RRAWQRGGEV FAEVALDEET AEEAAAFGLH PALLDSALHA
2710 2720 2730 2740 2750
IGMGGLGNTG GEGRLPFAWT GVSLYASGAS ALRVHLTPAR TDGVRLEIAD
2760 2770 2780 2790 2800
TTGAPVAAVE TLGLRPVSAE QIQSARTAYH ESLFRLEWAT TAGLADAAGA
2810 2820 2830 2840 2850
DVPADGRWAV LGADPLGLGT SAYGDLETLT GAVAAGTAPA PEYVVVSPSA
2860 2870 2880 2890 2900
EVGEQAARGA HRAAGAALSV VQRWLEEERF GDAPLVVVTR GAVAVEADEP
2910 2920 2930 2940 2950
VADLAGAAVW GLLRSAQSEN PGRFVLVDTD GADESLRALP AALASGEPQL
2960 2970 2980 2990 3000
AVRAGTVSVP RLARVAMEPE GGDARGLDPE GTVLVTGASG SLGGLVARHL
3010 3020 3030 3040 3050
VAERGVRQLL LVSRRGDQAP GAAELGAELA GLGAEVAWAA CDVADRNALA
3060 3070 3080 3090 3100
AALATVPAEH PLTAVVHTAG VLDDGVIGSL TSERVDHVMR PKVDAAWNLH
3110 3120 3130 3140 3150
ELTRELDLTA FVLFSSSSGV FGGPGQGNYA ASNAFLDALA RHRAAQGLPA
3160 3170 3180 3190 3200
TALAWGLWAG AGMGSTLDEA DIARMRRAGL PPLPVAEGLA LLDTALTVSE
3210 3220 3230 3240 3250
ASLVPMRVDI AALRTQAASG AVSPLFRGLV RIPARRAVDA VAAGGESGLA
3260 3270 3280 3290 3300
GRLAGLSEPE QERLLLDLVR GQVATVLGYA GAETIGSGRA FKELGFDSLT
3310 3320 3330 3340 3350
AVELRNQLNT VTGLRLPATL IFDYPDPQVL ARQLRTELVG ERSPVVHTPV
3360 3370 3380 3390 3400
PVVAATDDEP IAIVAMSCRY PGGVTTPEEL WQLLAAGEDG ISRFPDNRGW
3410 3420 3430 3440 3450
DLEALYDPDP ETQGTSYARE GGFLHDAAEF DPAFFGISPR EALAMDPQQR
3460 3470 3480 3490 3500
LLLETSWEAF ERAGIDPLSV RGSRTGVFAG VMYHDYGSRL HAVPSEVEGY
3510 3520 3530 3540 3550
LGTGSSSSVV SGRVAYTFGL EGPAVTVDTA CSSSLVALHL AAQALRQGEC
3560 3570 3580 3590 3600
SLALAGGVTV MFTPGTFIDF SRQRGLARDG RCKSFAAAAD GTGWGEGAGM
3610 3620 3630 3640 3650
LLLERLSDAR RHGHEVLAIV RGSAVNQDGA SNGLTAPNGP SQQRVIRQAL
3660 3670 3680 3690 3700
ANARLTTGEV DVVEAHGTGT TLGDPIEAQA LLATYGRERD AEQPLWLGSV
3710 3720 3730 3740 3750
KSNLGHTQAA SGVAGVIKMV LSMRHGLLPR TLHVDQPSPH VDWSAGAVSL
3760 3770 3780 3790 3800
LTEAREWPES GRPRRAAVSS FGISGTNAHA IIEQPPAPEP DEPAAEPEAL
3810 3820 3830 3840 3850
PYVPVLLSAR TEDGVRAQAR RLRSRIAAEP GTSLTDLGFS LATTRAALEH
3860 3870 3880 3890 3900
RVALVAEGHD EALGALDALA RGEHPAQALR GVATEGKVAF LFTGQGSQRL
3910 3920 3930 3940 3950
GMGRELYGAF PRFAEALDEV CDALDPHLER PLQTVLFGED AQALDRTAVT
3960 3970 3980 3990 4000
QPALFAIEVA LFRLVEAWGL KADYLSGHSI GELAAAHVAG VFSLADACAL
4010 4020 4030 4040 4050
VAARGRLMQE LPAGGAMIAV QASEDEVAPL LTDRVSIAAL NGPTSVVIAG
4060 4070 4080 4090 4100
DEDAAVAIAT SFEARGRKTK RLTVSHAFHS PHMDPMLADF RKLAEGLTFN
4110 4120 4130 4140 4150
APKIPLVSCL TGTVVSADEI RLPEFWVRHV RESVRFVDGV RTLREQGVTT
4160 4170 4180 4190 4200
YLELGPDGVL CAMGEDCLAE TETGTAAGSG TGTDRDGDTD AVFVPALRGG
4210 4220 4230 4240 4250
RPEAQALATA LAHVHVRGAA PDWAAVYGGR GARRVELPTY AFQRQRYWLD
4260 4270 4280 4290 4300
VGISVEDVIS AGLDTADHPL LGAAVELPDT GGFVFTGRLS LLTHPWLADH
4310 4320 4330 4340 4350
AVMDTVLLPG TAFVELALRA GHEAGCDTVE ELTLQAPLVL PEQGAVQLRL
4360 4370 4380 4390 4400
ELAAADETGR RPLTLHSRRE DVPADEPWIR HATGFLAPGG ANAQGGPDEP
4410 4420 4430 4440 4450
VDLSAWPPAD ATALATEEFY EGAAAAGLGY GPVFQGLHAA WRRGEELFAE
4460 4470 4480 4490 4500
IRLPQGFEPR AAGYGVHPAL LDAALHTLGL DPQGEGSEGA RLPFAWTGVR
4510 4520 4530 4540 4550
LHAGGAASLR VRLRPGADGV SLHLADGTGA AVATIDGLVL RPLAAEQLDA
4560 4570 4580 4590 4600
SRAAHHESLF RPEWAALSAS ATGIPLGERW VTLGAATGFT VGGERLDDHA
4610 4620 4630 4640 4650
DLAALAAALD GGASAPDVVV APLTGVASLT GVASLTGVAS LTANGGAAPL
4660 4670 4680 4690 4700
TGTGSVAPLR AADGAASLPA TDGKAPLTAT GGIASLPESA RAAARDALDL
4710 4720 4730 4740 4750
VQNWLNEQRL ADTRLVLVTR GAVAAAPGED VTDLAHTTAW GLVKSAQSEN
4760 4770 4780 4790 4800
PGRFVLVDID GTDASQRALP SVLATDEPQL ALRSGTGHAY RLARVPAPAD
4810 4820 4830 4840 4850
TPEPAGLGDP EGTVLLSGAT GALGGLFARH LVAERGVRHL LLVSRRGGEA
4860 4870 4880 4890 4900
PDAAELAAEL GALGADVTWA ACDTADRDAL AATLAAIPVE HPLTAVVHTA
4910 4920 4930 4940 4950
GVLDDGVISS LTGERIDTVL RPKVDAAWNL HELTRELDPA AFVLFSSAAG
4960 4970 4980 4990 5000
AFGSSGQGNY AAANTFLDAL AQHRHAHGLP ASSLAWGLWA TADGMAGSLD
5010 5020 5030 5040 5050
TSDVTRISRG GFAALGQDEG LALFDVAGTL PEAALVPIRI DTGALRGQAA
5060 5070 5080 5090 5100
AGLLPPLLRG LVRTPVRRSA DTGATSGVVA DSGAGSLATR LAGLSETERD
5110 5120 5130 5140 5150
RELLEVVRGH VAAVLGHATP DDVDAGRGFL DLGFDSLTAV DLRNRLGAAA
5160 5170 5180 5190 5200
GLRLPVTLIF DYPTPTALAG YLREELGLDS AAGHQPVHAE LDKLEAILAT
5210 5220 5230 5240 5250
IAPDDLDRPG ITTRLRDLLS KWNETQSATD STAEDREIQS ATADEIFDLL

DDELGLS
Length:5,257
Mass (Da):549,796
Last modified:February 4, 2015 - v1
Checksum:iEF2B8B6CDD6BCA05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006567 Genomic DNA Translation: AGP57750.1

Genome annotation databases

EnsemblBacteriaiAGP57750; AGP57750; M271_31610
KEGGisrc:M271_31610
PATRICifig|1343740.8.peg.4288

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006567 Genomic DNA Translation: AGP57750.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGP57750; AGP57750; M271_31610
KEGGisrc:M271_31610
PATRICifig|1343740.8.peg.4288

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.40.366.10, 3 hits
3.40.47.10, 3 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR015083 Polyketide_synth_docking
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 3 hits
PF08990 Docking, 1 hit
PF16197 KAsynt_C_assoc, 3 hits
PF00109 ketoacyl-synt, 3 hits
PF02801 Ketoacyl-synt_C, 3 hits
PF08659 KR, 3 hits
PF00550 PP-binding, 3 hits
PF14765 PS-DH, 2 hits
SMARTiView protein in SMART
SM00827 PKS_AT, 3 hits
SM00826 PKS_DH, 2 hits
SM00825 PKS_KS, 3 hits
SM00823 PKS_PP, 3 hits
SUPFAMiSSF47336 SSF47336, 3 hits
SSF51735 SSF51735, 6 hits
SSF52151 SSF52151, 3 hits
SSF53901 SSF53901, 3 hits
SSF55048 SSF55048, 3 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 3 hits
PS50075 CARRIER, 3 hits
PS00012 PHOSPHOPANTETHEINE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0NSU6_STRRN
AccessioniPrimary (citable) accession number: A0A0A0NSU6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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