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Protein
Submitted name:

Beta-ketoacyl synthase

Gene

M271_05680

Organism
Streptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994) (Streptomyces hygroscopicus (strain ATCC 29253))
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-ketoacyl synthaseImported
Gene namesi
ORF Names:M271_05680Imported
OrganismiStreptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994) (Streptomyces hygroscopicus (strain ATCC 29253))Imported
Taxonomic identifieri1343740 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000030183 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1763O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1728 – 1803CarrierInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 32Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK12436

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 2 hits
3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR015083 Polyketide_synth_docking
IPR036299 Polyketide_synth_docking_sf
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 2 hits
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF08990 Docking, 1 hit
PF16197 KAsynt_C_assoc, 2 hits
PF00109 ketoacyl-synt, 2 hits
PF02801 Ketoacyl-synt_C, 2 hits
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 2 hits
SMARTiView protein in SMART
SM00827 PKS_AT, 2 hits
SM00826 PKS_DH, 2 hits
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 2 hits
SM00823 PKS_PP, 1 hit
SUPFAMiSSF101173 SSF101173, 1 hit
SSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 4 hits
SSF52151 SSF52151, 2 hits
SSF53901 SSF53901, 2 hits
SSF55048 SSF55048, 2 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 2 hits
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A0N3T8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTEEKLRQ YLKKVTADLG QTRRRLREME ERSQEPVAIV SMACRFPGGI
60 70 80 90 100
TSPEDLWQLV ASRGDAIGEF PTDRGWDLNG LFHPDPDHSG TSYVRHGGFL
110 120 130 140 150
DRADGFDATF FGISPREALA AEPQQRQLLE VSWELIERAG IDPASLKGTP
160 170 180 190 200
TGVYAGAGIL GFGTPQIEKS AEGYLLTGNT LSVVSGRVAF TLGLEGPAVT
210 220 230 240 250
VDTACSSSLV AMHLACQALR QGECTLALAG GVTVMTTPNT FVEFSRQRGL
260 270 280 290 300
APDGRCKPFA AAADGTGFSE GVGLLLLERL SDARRNGHQV LAVLRGSAIN
310 320 330 340 350
QDGASNGLTA PNGPSQRRVI RQALINAQLS SAEVDAVEAH GTGTTLGDPI
360 370 380 390 400
EAEALLAAYG QDRPEDRPLL LGSLKSNIGH TQGAAGVAGV IKMVLALRHQ
410 420 430 440 450
LLPATLHVDE PTPQADWSGG AVRLLTDPVE WPRNERPRRA GVSAFGISGT
460 470 480 490 500
NAHVIVEQAP EEDVPKDPAC SGVGPVPWVL SGRSVEALRG QAGALAEWAG
510 520 530 540 550
DVFEPSLVDV GWSLVTARSV FEHRAVVVGG DRAGLLAGME ALAGGVSHPG
560 570 580 590 600
VVESGASVLT GAVGPVLVFP GQGSQWVGMG AELLGVSPVF AARVAECERV
610 620 630 640 650
LASYVDWSLM DVLCGVEGAA DLGRVDVVQP VLWAVMVSLA AVWAGYGVRP
660 670 680 690 700
AAVVGHSQGE IAAAVVAGAL SLEDGAKVVA LRSKALRRLA GGGAMASLGA
710 720 730 740 750
GQERAGQLLS DLGDQAAGVG VAAVNGPSST VVSGPPGRVA AVVAACQEVG
760 770 780 790 800
ERARLIEVDY ASHGPQVDEI RAELNEVLAG VRPVVGGAGG VAFYSTVTGG
810 820 830 840 850
RVDAAGLDTD YWVRNLRERV RFADAVEALL ADGHRVFIEA STHPVLTIGM
860 870 880 890 900
QETFEQAGVD AVAVPTLRRD HGGQAQLLHS LGQAFIAGAE VDWKAAFPAD
910 920 930 940 950
PTPRTVDLPT YAFQHQRYWM NASGATGDPS GLGLVAANHP LLGAAVELAD
960 970 980 990 1000
GSTHLLTGRI AAGGGDGWLG EHIVADAVLA PGAALVEWAL RAADEVGCGG
1010 1020 1030 1040 1050
VEELALQVPL VLPESGGLRV QVVLGAAAAD GRRDVRIYSR PDGEADPGAD
1060 1070 1080 1090 1100
AGWVCHAEGV LSPAEEGADQ TAEGLGGTWP PAGAQPVDLE GFYERSAAAG
1110 1120 1130 1140 1150
YAYGPSFQGV RAVWRDGADL LAEVALPEVA GDADGFGIHP ALLDAALHPA
1160 1170 1180 1190 1200
LLLDTGPDQG RDGGQVWLPF AWNGVSLWAA GASTVRVRLS PYRDGAEGER
1210 1220 1230 1240 1250
AVRLVVADAV GDPVLTVDSL VTRQAAVEQL RAGATRGVDG LFVLDWTPLP
1260 1270 1280 1290 1300
QPTRTDEPVA GRDSWAVLAA EGAGPDLEAL LARLDDTKPV PAVVLAEFPR
1310 1320 1330 1340 1350
PDADADADAV ADLATAGLAT VQRALALVRQ WLAEPRLADA RLVMVTRGAV
1360 1370 1380 1390 1400
TVADAEGGTD VAAAALWGLL RSAQAENPGR FLLLDLDLGL DPVADASADN
1410 1420 1430 1440 1450
VRDVVARAVD LDEPQLAVRD GQVWVPRLIR ASVDSDLEDR DAPVALDPDG
1460 1470 1480 1490 1500
TVLVTGGTGT LGGLVAEHLV RTWQVGHLLL VSRRGPDAPG ADELGARLEE
1510 1520 1530 1540 1550
LGARVRIAAV DVTDGSAVAE LVAGIDADHP LTGVIHATGL LDDAVVTSQT
1560 1570 1580 1590 1600
PERLARVWAA KAMGAAHLHT ATAGLPLSLF AMFSSAAGVL GSPGQSNYAA
1610 1620 1630 1640 1650
ANAFCDALAA HRQARGLPGL SVAWGLWAQS SELTGNLAAT DRARMSRSGI
1660 1670 1680 1690 1700
TAMSSEKALG LLDAACAQGG SLCVAAALDT VGVGRQELPA VLRGLVSGRT
1710 1720 1730 1740 1750
ARRMAAGGPS ASGLAAELVG LDAVGRLGVV VDVVRGGVAV VLGFGSLGEV
1760 1770 1780 1790 1800
RVDVAFKELG FDSLTAVELR NRLSVVTGLR LPATLVFDYP TPRVLAEYLC
1810 1820 1830 1840 1850
TRLTGETVGT VGTRAPLAAR ADGDEPIAIV AMTCRFPGGV SSPEELWDLV
1860 1870 1880 1890 1900
ASGRDAIGEF PTGRGWDLDG LFHPDPDHPG TSYARKGGFL YDADAFDAAF
1910 1920 1930 1940 1950
FGINPREALA TDPQQRLLLE ASWEVLERAG IDPVSLKGSP TGVYAGVMYH
1960 1970 1980 1990 2000
DYAAGLSGGD ARLEGYAMLA SSGSVVSGRV AYTLGFEGPA VTVDTACSSS
2010 2020 2030 2040 2050
LVAMHLASQA LRQGECTLAL AGGVTVMATP DVFTGFSRQR GLAPDGRCKP
2060 2070 2080 2090 2100
FAAAADGTGW SEGVGVLLLE RLSDARRNGH DVLAVIRGSA VNQDGASNGL
2110 2120 2130 2140 2150
TAPNGPSQQR VIRQALASGG LSPSDVDAVE AHGTGTTLGD PIEAQALLAT
2160 2170 2180 2190 2200
YGQDRAAERP LLLGSIKSNI GHAQAAAGVA GVIKMVQAIR HGTLPASLHI
2210 2220 2230 2240 2250
DEPTPHVDWE SGAVRLLTEP VEWPNGERPR RAGVSSFGAS GTNAHLLLEQ
2260 2270 2280 2290 2300
ASEPVERATT EPVTSPDHLR PVPWPLSARS AEALRGQAAA LAERVAGHPE
2310 2320 2330 2340 2350
MSVADVGWSL ATSRSLFEHR AVALADDRAE LVAAMEALAT GELHPGVVLP
2360 2370 2380 2390 2400
GSGAAAGKTV WLFSGQGSQR QGMGAGLYDG FPVFATAFDE VCGLLDPHLE
2410 2420 2430 2440 2450
HPLGDVVFHG VAERPGLLDH TTYAQAGLFA LHIALARLLD SFGVRPDAVI
2460 2470 2480 2490 2500
GHSIGEIAAA HVAGVFDLPD ACRLVAARAT LMGQLPSGGG MATIAATADE
2510 2520 2530 2540 2550
LAADLAAYDG QVSIAALNTP GNTVVSGPIE LVADIRATWA ARGRKTRTLT
2560 2570 2580 2590 2600
VSHAFHSPLM DPILEPFAQS IGGLAFHRPT LPVLSNLTGE PADEEMATPD
2610 2620 2630 2640 2650
YWVRHIRQPV RFHPAITHIA PETGVFLELG PDPVLATATQ HTLQHLATDE
2660 2670 2680 2690 2700
ATTDTDEGGS EGVAGRPSPL VAATLSRKRP DAHALGHALA QLHTNGADVD
2710 2720 2730 2740 2750
WAHWFPADPA PRTVDLPTYA FQRERYWLAA GGGVGDVGAA GLQRVEHAHL
2760 2770 2780 2790 2800
PAAVGLADGG LVLTGRISAG GAGGRLAEHV MAGAVLVPGA ALVEWALRAA
2810 2820 2830 2840 2850
DEAGCGGVEE LALQVPLVLP ASGGLRVQVV VGVATEDGRR DVRVYSRPDR
2860 2870 2880 2890 2900
DVEPGADPGW VCHAEGVLGP SSPQSPARGP VDEPGPAWPP VGAEPVRLDG
2910 2920 2930 2940 2950
FYERAEASGY AYGPSFRGLR AVWRDGADLF AEVALPEAAG DPEGFGIHPA
2960 2970 2980 2990 3000
LLDAALHPAF LLDRPEEDHD DGRVWLPFAW NGVSLWAGGA TTVRVRLSPQ
3010 3020 3030 3040 3050
RQESGGAEGE RGLRVEAADA VGAPVLTVDS LVMRPAAVDQ LRASGGPRVD
3060 3070 3080 3090 3100
GLFTLEWTSL PAPAQDTDTE GQEPDPADGG GWAVLGPDEC GPIAPGAVHH
3110 3120 3130 3140 3150
PRLEALVSAL DGDGPVPSVA IAYLLALGDT SERHIGTDLA ADGLAASEWV
3160 3170 3180 3190 3200
LELVRGWLAE PRLADARLVV VTRGAVAIDA PEAESPGDGG VDVAGAAVCG
3210 3220 3230 3240 3250
LVRSAQAENP GRFLLVDLDP RTEPLAEDVR GAVAWAAHLD EPQVALRAGR
3260 3270 3280 3290 3300
LRVPRLMRAG GMSSGGVAAL VGQPAWRLEL TGAATVENVK PVPCPEVLEP
3310 3320 3330 3340 3350
LGPRQVRVAV HAAGINFRDA LISLGMVPGQ TGLGGEGAGV VLGHGSEVTG
3360 3370 3380 3390 3400
LAVGDRVMGV FDRAFGPTAV TDGRMVAPIP VGWTYPQAAS VPVAYLTAWY
3410 3420 3430 3440 3450
GLVELAGLRA GESVLIHAAT GGVGTAAVRI ARHLGAEVYA TASPGKHVVL
3460 3470 3480 3490 3500
EEMGIDAAHR ASSRDLDFEE VFREATGGRG VDVVLNSLAG PFVDASLRLL
3510 3520 3530 3540 3550
AEGGRLMEMG KTDLRDPERV AEEHPGVTYQ VYDLITGAGP ERIGRMLGEL
3560 3570 3580 3590 3600
GELFTTGAGE SIGVTEATGA AEATGAAEAA EAAEATGATG ATGATGATGA
3610 3620 3630 3640 3650
TGATGATGAT GATGATGATG STGAADAAGA ADAXXXXXXX XXPGPPEPPG
3660 3670
LPKPPKSPGP HVRPGPPHPC RRCRFGPGR
Length:3,679
Mass (Da):378,979
Last modified:February 4, 2015 - v1
Checksum:i388C95A17FD65C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006567 Genomic DNA Translation: AGP52762.1

Genome annotation databases

EnsemblBacteriaiAGP52762; AGP52762; M271_05680
KEGGisrc:M271_05680

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006567 Genomic DNA Translation: AGP52762.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGP52762; AGP52762; M271_05680
KEGGisrc:M271_05680

Phylogenomic databases

KOiK12436

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 2 hits
3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR015083 Polyketide_synth_docking
IPR036299 Polyketide_synth_docking_sf
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 2 hits
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF08990 Docking, 1 hit
PF16197 KAsynt_C_assoc, 2 hits
PF00109 ketoacyl-synt, 2 hits
PF02801 Ketoacyl-synt_C, 2 hits
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 2 hits
SMARTiView protein in SMART
SM00827 PKS_AT, 2 hits
SM00826 PKS_DH, 2 hits
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 2 hits
SM00823 PKS_PP, 1 hit
SUPFAMiSSF101173 SSF101173, 1 hit
SSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 4 hits
SSF52151 SSF52151, 2 hits
SSF53901 SSF53901, 2 hits
SSF55048 SSF55048, 2 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 2 hits
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0N3T8_STRRN
AccessioniPrimary (citable) accession number: A0A0A0N3T8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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