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1 to 25 of 129  Show
  1. 1
    "A naturally occurring splicing variant."
    Cheng H., Feng Y.-H.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation."
    Sun R., Chen X., Yang V.W.
    J. Biol. Chem. 276:6897-6900(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Overexpression of KLF5 in transfected cells led to increased cell proliferation including foci formation and anchorage-independent growth in a manner consistent with a transformed phenotype.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  3. 3
    "Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene."
    Dang D.T., Zhao W., Mahatan C.S., Geiman D.E., Yang V.W.
    Nucleic Acids Res. 30:2736-2741(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: This study describes the opposite effect of KLF4 and KLF5 on transcription of the KLF4 gene.
    Source: GeneRIF:688.

    This publication is mapped to 12 other entries.

  4. 4
    "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer."
    Chen C., Bhalala H.V., Qiao H., Dong J.T.
    Oncogene 21:6567-6572(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: KLF5 suppresses tumor cell growth in breast cancer.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  5. 5
    "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs."
    Yang X.O., Doty R.T., Hicks J.S., Willerford D.M.
    Blood 101:4492-4499(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: KLF5 bound and efficiently transactivated the TCR Dbeta1 promoter.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  6. 6
    "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer."
    Chen C., Bhalala H.V., Vessella R.L., Dong J.T.
    Prostate 55:81-88(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Gene deletion and loss of expression and cell growth suppression indicate that KLF5 may be tumor suppressor gene at 13q21 in prostate cancer. Mutation and promoter methylation do not commonly inactivate KLF5 in prostate cancer.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  7. 7
    "Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer."
    Ohnishi S., Ohnami S., Laub F., Aoki K., Suzuki K., Kanai Y., Haga K., Asaka M., Ramirez F., Yoshida T.
    Biochem. Biophys. Res. Commun. 308:251-256(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: KLF4 but not KLF5 was frequently downregulated in bladder cancer cell lines and cancer tissues.
    Source: GeneRIF:688.

    This publication is mapped to 10 other entries.

  8. 8
    "Regulation of platelet-derived growth factor-A chain by Kruppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB."
    Aizawa K., Suzuki T., Kada N., Ishihara A., Kawai-Kowase K., Matsumura T., Sasaki K., Munemasa Y., Manabe I., Kurabayashi M., Collins T., Nagai R.
    J. Biol. Chem. 279:70-76(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: KLF5 and p50 are important for induction of PDGF-A chain.
    Source: GeneRIF:688.

    This publication is mapped to 13 other entries.

  9. 9
    "Immunohistochemical study of surgically excised choroidal neovascular membranes."
    Sato T., Kanda T., Iida T., Takahashi T., Kishi S., Hoshino Y.
    J. Int. Med. Res. 31:402-406(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: BTEB2 a zinc finger transcription factor may contribute to the establishment of the choroidal neovascularization observed in the pathogenesis of age-related macular degeneration and idiopathic choroidal neovascularization.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  10. 10
    "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain."
    Miyamoto S., Suzuki T., Muto S., Aizawa K., Kimura A., Mizuno Y., Nagino T., Imai Y., Adachi N., Horikoshi M., Nagai R.
    Mol. Cell. Biol. 23:8528-8541(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  11. 11
    "Intestinal tumor progression is associated with altered function of KLF5."
    Bateman N.W., Tan D., Pestell R.G., Black J.D., Black A.R.
    J. Biol. Chem. 279:12093-12101(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: intestinal tumor progression is associated with a change in the growth-related functions of KLF5.
    Source: GeneRIF:688.

    This publication is mapped to 10 other entries.

  12. 12
    "Kruppel-like factor 5 mediates the transforming activity of oncogenic H-Ras."
    Nandan M.O., Yoon H.S., Zhao W., Ouko L.A., Chanchevalap S., Yang V.W.
    Oncogene 23:3404-3413(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: KLF5 mediates the transforming effect of oncogenic H-Ras in NIH3T3 fibroblast cells and does so by transactivating the cyclin D1 promoter.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  13. 13
    "All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5."
    Chanchevalap S., Nandan M.O., Merlin D., Yang V.W.
    FEBS Lett. 578:99-105(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Results indicate that Kruppel-like factor 5 is a potential mediator for the inhibitory effect of all-trans retinoid acid on intestinal epithelial cell proliferation; This study describes that the inhibitory effect of all-trans retinoic acid (ATRA) on proliferation of intestinal epithelial cells is a result of ATRA-mediated expression of KLF5.
    Source: GeneRIF:688.

    This publication is mapped to 9 other entries.

  14. 14
    "The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Kruppel-like factor 5 through direct interaction."
    Matsumura T., Suzuki T., Aizawa K., Munemasa Y., Muto S., Horikoshi M., Nagai R.
    J. Biol. Chem. 280:12123-12129(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: HDAC1 negatively regulates the cardiovascular transcription factor KLF5 through direct interaction.
    Source: GeneRIF:688.

    This publication is mapped to 15 other entries.

  15. 15
    "Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells."
    Chen C., Sun X., Ran Q., Wilkinson K.D., Murphy T.J., Simons J.W., Dong J.T.
    Oncogene 24:3319-3327(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: KLF5 protein is degraded at least in part through ubiquitination-proteasome pathway which may have become hyperactive for KLF5 in cancer cells.
    Source: GeneRIF:688.

    This publication is cited by 1 and mapped to 6 other entries.

  16. 16
    "Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation."
    Ghaleb A.M., Nandan M.O., Chanchevalap S., Dalton W.B., Hisamuddin I.M., Yang V.W.
    Cell Res. 15:92-96(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: This is an review article that summarizes the function of KLF4 and KLF5 in regulating cell proliferation.
    Source: GeneRIF:688.

    This publication is mapped to 12 other entries.

  17. 17
    Category: Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:688.

    This publication is mapped to 51 other entries.

  18. 18
    "A functional screen for Kruppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element."
    Zhang P., Basu P., Redmond L.C., Morris P.E., Rupon J.W., Ginder G.D., Lloyd J.A.
    Blood Cells Mol. Dis. 35:227-235(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: In co-transfection assays in K562 cells it was demonstrated that KLF2 5 and 13 positively regulate and KLF8 negatively regulates the gamma-globin gene through the CACCC promoter element.
    Source: GeneRIF:688.

    This publication is mapped to 15 other entries.

  19. 19
    Category: Function.
    Annotation: KLF5 is a key component of the transcription factor network controlling adipocyte differentiation.
    Source: GeneRIF:688.

    This publication is mapped to 30 other entries.

  20. 20
    "Significance of the transcription factor KLF5 in cardiovascular remodeling."
    Nagai R., Suzuki T., Aizawa K., Shindo T., Manabe I.
    J. Thromb. Haemost. 3:1569-1576(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: KLF5 is an essential transcription factor in cardiovascular remodeling (review).
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  21. 21
    "Kruppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation."
    Nandan M.O., Chanchevalap S., Dalton W.B., Yang V.W.
    FEBS Lett. 579:4757-4762(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: This study reports that KLF5 is activated by oncogenic HRAS and that activated KLF5 promotes mitosis by inducing transcription of the cyclin B1 and Cdc2 genes.
    Source: GeneRIF:688.

    This publication is mapped to 17 other entries.

  22. 22
    "Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells."
    Chen C., Sun X., Guo P., Dong X.Y., Sethi P., Cheng X., Zhou J., Ling J., Simons J.W., Lingrel J.B., Dong J.T.
    J. Biol. Chem. 280:41553-41561(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: KLF5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.
    Source: GeneRIF:688.

    This publication is mapped to 9 other entries.

  23. 23
    Category: Function.
    Annotation: KLF2 is a transcription factor important in the integration of multiple endothelial functions associated with regions of the arterial vasculature that are relatively resistant to atherogenesis.
    Source: GeneRIF:688.

    This publication is mapped to 9 other entries.

  24. 24
    "Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells."
    Chanchevalap S., Nandan M.O., McConnell B.B., Charrier L., Merlin D., Katz J.P., Yang V.W.
    Nucleic Acids Res. 34:1216-1223(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: This study describes that KLF5 is an important downstream mediator for the pro-inflammatory activity of NF-kB in intestinal epithelial cells.
    Source: GeneRIF:688.

    This publication is mapped to 7 other entries.

  25. 25
    "KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia."
    Zhu N., Gu L., Findley H.W., Chen C., Dong J.T., Yang L., Zhou M.
    J. Biol. Chem. 281:14711-14718(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: analysis of a novel regulatory pathway for the expression of survivin under the control of KLF5 and p53.
    Source: GeneRIF:688.

    This publication is mapped to 201 other entries.

1 to 25 of 129  Show
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