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Protein

Angiotensin-converting enzyme

Gene

Ace

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-2022377 Metabolism of Angiotensinogen to Angiotensins

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesi
Name:AceImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2493 Ace

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500820230336 – 1133Angiotensin-converting enzymeSequence analysisAdd BLAST1098

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000007467 Expressed in 9 organ(s), highest expression level in lung

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3690 Eukaryota
ENOG410XPJ3 LUCA
GeneTreeiENSGT00520000055576
OrthoDBiEOG091G033S

Family and domain databases

CDDicd06461 M2_ACE, 2 hits
InterProiView protein in InterPro
IPR001548 Peptidase_M2
PANTHERiPTHR10514 PTHR10514, 2 hits
PfamiView protein in Pfam
PF01401 Peptidase_M2, 2 hits
PRINTSiPR00791 PEPDIPTASEA

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A0A0MXV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAASGQRGR WPLSPPLLML SLLLLLLLPP SPAPALDPGL QPGNFSADEA
60 70 80 90 100
GAQLFADSYN SSAEVVMFQS TAASWAHDTN ITEENARLQE EAALINQEFA
110 120 130 140 150
EVWGKKAKEL YESIWQNFTD QKLRRIIGSV QTLGPANLPL TQRLQYNSLL
160 170 180 190 200
SNMSRIYSTG KVCFPNKTAT CWSLDPELTN ILASSRNYAK VLFAWEGWHD
210 220 230 240 250
AVGIPLRPLY QDFTALSNEA YRQDGFSDTG AYWRSWYESP SFEESLEHLY
260 270 280 290 300
HQVEPLYLNL HAFVRRALHR RYGDKYINLR GPIPAHLLGD MWAQSWENIY
310 320 330 340 350
DMVVPFPDKP NLDVTSTMVQ KGWNATHMFR VAEEFFTSLG LSPMPPEFWA
360 370 380 390 400
ESMLEKPADG REVVCHASAW DFYNRKDFRI KQCTRVTMDQ LSTVHHEMGH
410 420 430 440 450
VQYYLQYKDL HVSLRRGANP GFHEAIGDVL ALSVSTPAHL HKIGLLDRVA
460 470 480 490 500
NDIESDINYL LKMALEKIAF LPFGYLVDQW RWGVFSGRTP PSRYNYDWWY
510 520 530 540 550
LRTKYQGICP PVARNETHFD AGAKFHIPSV TPYIRYFVSF VLQFQFHQAL
560 570 580 590 600
CKEAGHQGPL HQCDIYQSTK AGAKLQQVLQ AGCSRPWQEV LKDLVGSDAL
610 620 630 640 650
DASALMEYFQ PVSQWLQEQN QRNGEVLGWP EYQWRPPLPD NYPEGIDLET
660 670 680 690 700
DEAKANRFVE EYDRTAKVLW NEYAEANWHY NTNITIEGSK ILLQKNKEVS
710 720 730 740 750
NHTLKYGTWA KTFDVSNFQN STIKRIIKKV QNVDRAVLPP NELEEYNQIL
760 770 780 790 800
LDMETTYSVA NVCYTNGTCL SLEPDLTNIM ATSRKYEELL WVWKSWRDKV
810 820 830 840 850
GRAILPFFPK YVDFSNKIAK LNGYSDAGDS WRSSYESDDL EQDLEKLYQE
860 870 880 890 900
LQPLYLNLHA YVRRSLHRHY GSEYINLDGP IPAHLLGNMW AQTWSNIYDL
910 920 930 940 950
VAPFPSAPSI DATEAMIKQG WTPRRIFKEA DNFFTSLGLL PVPPEFWNKS
960 970 980 990 1000
MLEKPTDGRE VVCHASAWDF YNGKDFRIKQ CTSVNMEELV IAHHEMGHIQ
1010 1020 1030 1040 1050
YFMQYKDLPV TFREGANPGF HEAIGDVLAL SVSTPKHLHS LNLLSSEGSG
1060 1070 1080 1090 1100
YEHDINFLMK MALDKIAFIP FSYLIDQWRW RVFDGSITKE NYNQEWWSLR
1110 1120 1130
LKYQGLCPPV PRSQGDFDPG SKFHVPANVP YIR
Length:1,133
Mass (Da):130,386
Last modified:October 5, 2016 - v2
Checksum:iAE03FC72D93C8AC4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P47820ACE_RAT
Angiotensin-converting enzyme
Ace Dcp1
1,313Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1133Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030583 Genomic DNA No translation available.
AABR07030584 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000010627; ENSRNOP00000010627; ENSRNOG00000062101

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MXV4_RAT
AccessioniPrimary (citable) accession number: A0A0A0MXV4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 30 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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