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Protein
Submitted name:

Neuron navigator 2

Gene

NAV2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Neuron navigator 2Imported
Gene namesi
Name:NAV2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166833.19
HGNCiHGNC:15997 NAV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166833

Expressioni

Gene expression databases

BgeeiENSG00000166833 Expressed in 219 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiA0A0A0MTL4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MTL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 192Calponin-homology (CH)InterPro annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili475 – 507Sequence analysisAdd BLAST33
Coiled coili1630 – 1657Sequence analysisAdd BLAST28
Coiled coili1679 – 1713Sequence analysisAdd BLAST35
Coiled coili1842 – 1869Sequence analysisAdd BLAST28
Coiled coili1877 – 1904Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IGVF Eukaryota
ENOG410XRG8 LUCA
GeneTreeiENSGT00910000144056

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR039041 Nav/unc-53
IPR027417 P-loop_NTPase
PANTHERiPTHR12784 PTHR12784, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

A0A0A0MTL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT
60 70 80 90 100
TYPSQIPLKS QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA
110 120 130 140 150
KSGHKRLIRD LQQDVTDGVL LAQIIQVVAN EKIEDINGCP KNRSQMIENI
160 170 180 190 200
DACLNFLAAK GINIQGLSAE EIRNGNLKAI LGLFFSLSRY KQQQQQPQKQ
210 220 230 240 250
HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH QPAPHQQSKA
260 270 280 290 300
QAEMQSRLPG PTARVSAAGS EAKTRGGSTT ANNRRSQSFN NYDKSKPVTS
310 320 330 340 350
PPPPPSSHEK EPLASSASSH PGMSDNAPAS LESGSSSTPT NCSTSSAIPQ
360 370 380 390 400
PGAATKPWRS KSLSVKHSAT VSMLSVKPPG PEAPRPTPEA MKPAPNNQKS
410 420 430 440 450
MLEKLKLFNS KGGSKAGEGP GSRDTSCERL ETLPSFEESE ELEAASRMLT
460 470 480 490 500
TVGPASSSPK IALKGIAQRT FSRALTNKKS SLKGNEKEKE KQQREKDKEK
510 520 530 540 550
SKDLAKRASV TERLDLKEEP KEDPSGAAVP EMPKKSSKIA SFIPKGGKLN
560 570 580 590 600
SAKKEPMAPS HSGIPKPGMK SMPGKSPSAP APSKEGERSR SGKLSSGLPQ
610 620 630 640 650
QKPQLDGRHS SSSSSLASSE GKGPGGTTLN HSISSQTVSG SVGTTQTTGS
660 670 680 690 700
NTVSVQLPQP QQQYNHPNTA TVAPFLYRSQ TDTEGNVTAE SSSTGVSVEP
710 720 730 740 750
SHFTKTGQPA LEELTGEDPE ARRLRTVKNI ADLRQNLEET MSSLRGTQVT
760 770 780 790 800
HSTLETTFDT NVTTEMSGRS ILSLTGRPTP LSWRLGQSSP RLQAGDAPSM
810 820 830 840 850
GNGYPPRANA SRFINTESGR YVYSAPLRRQ LASRGSSVCH VDVSDKAGDE
860 870 880 890 900
MDLEGISMDA PGYMSDGDVL SKNIRTDDIT SGYMTDGGLG LYTRRLNRLP
910 920 930 940 950
DGMAVVRETL QRNTSLGLGD ADSWDDSSSV SSGISDTIDN LSTDDINTSS
960 970 980 990 1000
SISSYANTPA SSRKNLDVQT DAEKHSQVER NSLWSGDDVK KSDGGSDSGI
1010 1020 1030 1040 1050
KMEPGSKWRR NPSDVSDESD KSTSGKKNPV ISQTGSWRRG MTAQVGITMP
1060 1070 1080 1090 1100
RTKPSAPAGA LKTPGTGKTD DAKVSEKGRL SPKASQVKRS PSDAGRSSGD
1110 1120 1130 1140 1150
ESKKPLPSSS RTPTANANSF GFKKQSGSAA GLAMITASGV TVTSRSATLG
1160 1170 1180 1190 1200
KIPKSSALVS RSAGRKSSMD GAQNQDDGYL ALSSRTNLQY RSLPRPSKSN
1210 1220 1230 1240 1250
SRNGAGNRSS TSSIDSNISS KSAGLPVPKL REPSKTALGS SLPGLVNQTD
1260 1270 1280 1290 1300
KEKGISSDNE SVASCNSVKV NPAAQPVSSP AQTSLQPGAK YPDVASPTLR
1310 1320 1330 1340 1350
RLFGGKPTKQ VPIATAENMK NSVVISNPHA TMTQQGNLDS PSGSGVLSSG
1360 1370 1380 1390 1400
SSSPLYSKNV DLNQSPLASS PSSAHSAPSN SLTWGTNASS SSAVSKDGLG
1410 1420 1430 1440 1450
FQSVSSLHTS CESIDISLSS GGVPSHNSST GLIASSKDDS LTPFVRTNSV
1460 1470 1480 1490 1500
KTTLSESPLS SPAASPKFCR STLPRKQDSD PHLDRNTLPK KGLRYTPTSQ
1510 1520 1530 1540 1550
LRTQEDAKEW LRSHSAGGLQ DTAANSPFSS GSSVTSPSGT RFNFSQLASP
1560 1570 1580 1590 1600
TTVTQMSLSN PTMLRTHSLS NADGQYDPYT DSRFRNSSMS LDEKSRTMSR
1610 1620 1630 1640 1650
SGSFRDGFEE VHGSSLSLVS STSSVYSTPE EKCQSEIRKL RRELDASQEK
1660 1670 1680 1690 1700
VSALTTQLTA NAHLVAAFEQ SLGNMTIRLQ SLTMTAEQKD SELNELRKTI
1710 1720 1730 1740 1750
ELLKKQNAAA QAAINGVINT PELNCKGNGT AQSADLRIRR QHSSDSVSSI
1760 1770 1780 1790 1800
NSATSHSSVG SNIESDSKKK KRKNWVNIQL RSSFKQAFGK KKSPKSASSH
1810 1820 1830 1840 1850
SDIEEMTDSS LPSSPKLPHN GSTGSTPLLR NSHSNSLISE CMDSEAETVM
1860 1870 1880 1890 1900
QLRNELRDKE MKLTDIRLEA LSSAHQLDQL REAMNRMQSE IEKLKAENDR
1910 1920 1930 1940 1950
LKSESQGSGC SRAPSQVSIS ASPRQSMGLS QHSLNLTEST SLDMLLDDTG
1960 1970 1980 1990 2000
ECSARKEGGR HVKIVVSFQE EMKWKEDSRP HLFLIGCIGV SGKTKWDVLD
2010 2020 2030 2040 2050
GVVRRLFKEY IIHVDPVSQL GLNSDSVLGY SIGEIKRSNT SETPELLPCG
2060 2070 2080 2090 2100
YLVGENTTIS VTVKGLAENS LDSLVFESLI PKPILQRYVS LLIEHRRIIL
2110 2120 2130 2140 2150
SGPSGTGKTY LANRLSEYIV LREGRELTDG VIATFNVDHK SSKELRQYLS
2160 2170 2180 2190 2200
NLADQCNSEN NAVDMPLVII LDNLHHVSSL GEIFNGLLNC KYHKCPYIIG
2210 2220 2230 2240 2250
TMNQATSSTP NLQLHHNFRW VLCANHTEPV KGFLGRFLRR KLMETEISGR
2260 2270 2280 2290 2300
VRNMELVKII DWIPKVWHHL NRFLEAHSSS DVTIGPRLFL SCPIDVDGSR
2310 2320 2330 2340 2350
VWFTDLWNYS IIPYLLEAVR EGLQLYGRRA PWEDPAKWVM DTYPWAASPQ
2360 2370 2380 2390 2400
QHEWPPLLQL RPEDVGFDGY SMPREGSTSK QMPPSDAEGD PLMNMLMRLQ
2410 2420 2430
EAANYSSPQS YDSDSNSNSH HDDILDSSLE STL
Length:2,433
Mass (Da):261,862
Last modified:January 7, 2015 - v1
Checksum:iC267AD549F6B22FA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IVL1NAV2_HUMAN
Neuron navigator 2
NAV2 HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
2,488Annotation score:
A0A0A0MTE8A0A0A0MTE8_HUMAN
Neuron navigator 2
NAV2
2,489Annotation score:
E9PNV5E9PNV5_HUMAN
Neuron navigator 2
NAV2
815Annotation score:
E9PLU3E9PLU3_HUMAN
Neuron navigator 2
NAV2
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009549 Genomic DNA No translation available.
AC015684 Genomic DNA No translation available.
AC023950 Genomic DNA No translation available.
AC090662 Genomic DNA No translation available.
AC111163 Genomic DNA No translation available.
AC113193 Genomic DNA No translation available.
KF511142 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000540292; ENSP00000443489; ENSG00000166833
UCSCiuc057zua.1 human

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MTL4_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MTL4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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