UniProtKB - A0A0A0MTJ0 (A0A0A0MTJ0_HUMAN)
Protein
Thyrotropin receptor
Gene
TSHR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.UniRule annotation
GO - Molecular functioni
- thyroid-stimulating hormone receptor activity Source: Ensembl
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- adult locomotory behavior Source: Ensembl
- B cell differentiation Source: Ensembl
- cochlea morphogenesis Source: Ensembl
- dopaminergic neuron differentiation Source: Ensembl
- inner ear receptor cell stereocilium organization Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- regulation of locomotion Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Thyrotropin receptorUniRule annotation |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12373, TSHR |
VEuPathDBi | HostDB:ENSG00000165409.15 |
Subcellular locationi
Plasma membrane
- Basolateral cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 419 – 440 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 452 – 477 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 497 – 517 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 538 – 560 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 580 – 606 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 627 – 649 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 661 – 681 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneUniRule annotationARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | UniRule annotationAdd BLAST | 21 | |
ChainiPRO_5013980011 | 22 – 764 | Thyrotropin receptorUniRule annotationAdd BLAST | 743 |
Keywords - PTMi
GlycoproteinARBA annotation, SulfationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000165409, Expressed in left lobe of thyroid gland and 116 other tissues |
ExpressionAtlasi | A0A0A0MTJ0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 431 – 678 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 248 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156510 |
HOGENOMi | CLU_006130_1_1_1 |
OMAi | CGGNEDM |
OrthoDBi | 257031at2759 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002131, Gphrmn_rcpt_fam IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR002274, TSH_rcpt |
PANTHERi | PTHR24372:SF0, PTHR24372:SF0, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF13306, LRR_5, 2 hits |
PRINTSi | PR00373, GLYCHORMONER PR00237, GPCRRHODOPSN PR01145, TSHRECEPTOR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MTJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPADLLQLV LLLDLPRDLG GMGCSSPPCE CHQEEDFRVT CKDIQRIPSL
60 70 80 90 100
PPSTQTLKLI ETHLRTIPSH AFSNLPNISR IYVSIDVTLQ QLESHSFYNL
110 120 130 140 150
SKVTHIEIRN TRNLTYIDPD ALKELPLLKF LGIFNTGLKM FPDLTKVYST
160 170 180 190 200
DIFFILEITD NPYMTSIPVN AFQGLCNETL TLKLYNNGFT SVQGYAFNGT
210 220 230 240 250
KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LDVSQTSVTA LPSKGLEHLK
260 270 280 290 300
ELIARNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM
310 320 330 340 350
CNESSMQSLR QRKSVNALNS PLHQEYEENL GDSIVGYKEK SKFQDTHNNA
360 370 380 390 400
HYYVFFEEQE DEIIGFGQEL KNPQEETLQA FDSHYDYTIC GDSEDMVCTP
410 420 430 440 450
KSDEFNPCED IMGYKFLRIV VWFVSLLALL GNVFVLLILL TSHYKLNVPR
460 470 480 490 500
FLMCNLAFAD FCMGMYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF
510 520 530 540 550
TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHACA IMVGGWVCCF
560 570 580 590 600
LLALLPLVGI SSYAKVSICL PMDTETPLAL AYIVFVLTLN IVAFVIVCCC
610 620 630 640 650
YVKIYITVRN PQYNPGDKDT KIAKRMAVLI FTDFICMAPI SFYALSAILN
660 670 680 690 700
KPLITVSNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK
710 720 730 740 750
RQAQAYRGQR VPPKNSTDIQ VQKVTHEMRQ GLHNMEDVYE LIENSHLTPK
760
KQGQISEEYM QTVL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP16473 | TSHR_HUMAN | Thyrotropin receptor | TSHR LGR3 | 764 | Annotation score: | ||
A0A1B0GUJ5 | A0A1B0GUJ5_HUMAN | Thyrotropin receptor | TSHR | 399 | Annotation score: | ||
Q0VAP8 | Q0VAP8_HUMAN | TSHR protein | TSHR | 231 | Annotation score: | ||
G3V381 | G3V381_HUMAN | Thyrotropin receptor | TSHR | 112 | Annotation score: | ||
A0A2R8Y709 | A0A2R8Y709_HUMAN | Thyrotropin receptor | TSHR | 89 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007262 Genomic DNA No translation available. AC010072 Genomic DNA No translation available. AC010582 Genomic DNA No translation available. AL136040 Genomic DNA No translation available. |
RefSeqi | NP_000360.2, NM_000369.2 XP_005268094.1, XM_005268037.4 |
Genome annotation databases
Ensembli | ENST00000298171; ENSP00000298171; ENSG00000165409 ENST00000541158; ENSP00000441235; ENSG00000165409 |
GeneIDi | 7253 |
KEGGi | hsa:7253 |
UCSCi | uc001xvd.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007262 Genomic DNA No translation available. AC010072 Genomic DNA No translation available. AC010582 Genomic DNA No translation available. AL136040 Genomic DNA No translation available. |
RefSeqi | NP_000360.2, NM_000369.2 XP_005268094.1, XM_005268037.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 4379, 1139 antibodies |
Genome annotation databases
Ensembli | ENST00000298171; ENSP00000298171; ENSG00000165409 ENST00000541158; ENSP00000441235; ENSG00000165409 |
GeneIDi | 7253 |
KEGGi | hsa:7253 |
UCSCi | uc001xvd.1, human |
Organism-specific databases
CTDi | 7253 |
HGNCi | HGNC:12373, TSHR |
OpenTargetsi | ENSG00000165409 |
VEuPathDBi | HostDB:ENSG00000165409.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156510 |
HOGENOMi | CLU_006130_1_1_1 |
OMAi | CGGNEDM |
OrthoDBi | 257031at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7253, 4 hits in 875 CRISPR screens |
ChiTaRSi | TSHR, human |
GenomeRNAii | 7253 |
Gene expression databases
Bgeei | ENSG00000165409, Expressed in left lobe of thyroid gland and 116 other tissues |
ExpressionAtlasi | A0A0A0MTJ0, baseline and differential |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002131, Gphrmn_rcpt_fam IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR002274, TSH_rcpt |
PANTHERi | PTHR24372:SF0, PTHR24372:SF0, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF13306, LRR_5, 2 hits |
PRINTSi | PR00373, GLYCHORMONER PR00237, GPCRRHODOPSN PR01145, TSHRECEPTOR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MTJ0_HUMAN | |
Accessioni | A0A0A0MTJ0Primary (citable) accession number: A0A0A0MTJ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | February 10, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |