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Entry version 40 (16 Jan 2019)
Sequence version 1 (07 Jan 2015)
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Protein
Submitted name:

E3 ubiquitin-protein ligase RNF213

Gene

RNF213

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase RNF213Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF213Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173821.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14539 RNF213

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000173821

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A0A0MTC1

PeptideAtlas

More...
PeptideAtlasi
A0A0A0MTC1

PRoteomics IDEntifications database

More...
PRIDEi
A0A0A0MTC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173821 Expressed in 193 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A0MTC1 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A0A0A0MTC1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4046 – 4084RING-typeInterPro annotationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili398 – 418Sequence analysisAdd BLAST21
Coiled coili863 – 883Sequence analysisAdd BLAST21
Coiled coili1442 – 1462Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00630000089884

Identification of Orthologs from Complete Genome Data

More...
OMAi
SARHLEW

Database of Orthologous Groups

More...
OrthoDBi
840at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR031248 RNF213
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR22605 PTHR22605, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00097 zf-C3HC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MTC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECPSCQHVS KEETPKFCSQ CGERLPPAAP IADSENNNST MASASEGEME
60 70 80 90 100
CGQELKEEGG PCLFPGSDSW QENPEEPCSK ASWTVQEGAT SEVLVDAAVD
110 120 130 140 150
LISDEWEAAN AIPSKRRKQD AAPLEAASVP SADCEQSKKK KRKKKKKGNK
160 170 180 190 200
SASSELASLP LSPASPCHLT LLSNPWPQDT ALPHSQAQQS GPTGQPSQPP
210 220 230 240 250
GTATTPLEGD GLSAPTEVGD SPLQAQALGE AGVATGSEAQ SSPQFQDHTE
260 270 280 290 300
GEDQDASIPS GGRGLSQEGT GPPTSAGEGH SRTEDAAQEL LLPESKGGSS
310 320 330 340 350
EPGTELQTTE QQAGASASMA VDAVAEPANA VKGAGKEMKE KTQRMKQPPA
360 370 380 390 400
TTPPFKTHCQ EAETKTKDEM AAAEEKVGKN EQGEPEDLKK PEGKNRSAAA
410 420 430 440 450
VKNEKEQKNQ EADVQEVKAS TLSPGGGVTV FFHAIISLHF PFNPDLHKVF
460 470 480 490 500
IRGGEEFGES KWDSNICELH YTRDLGHDRV LVEGIVCISK KHLDKYIPYK
510 520 530 540 550
YVIYNGESFE YEFIYKHQQK KGEYVNRCLF IKSSLLGSGD WHQYYDIVYM
560 570 580 590 600
KPHGRLQKVM NHITDGPRKD LVKGKQIAAA LMLDSTFSIL QTWDTINLNS
610 620 630 640 650
FFTQFEQFCF VLQQPMIYEG QAQLWTDLQY REKEVKRYLW QHLKKHVVPL
660 670 680 690 700
PDGKSTDFLP VDCPVRSKLK TGLIVLFVVE KIELLLEGSL DWLCHLLTSD
710 720 730 740 750
ASSPDEFHRD LSHILGIPQS WRLYLVNLCQ RCMDTRTYTW LGALPVLHCC
760 770 780 790 800
MELAPRHKDA WRQPEDTWAA LEGLSFSPFR EQMLDTSSLL QFMREKQHLL
810 820 830 840 850
SIDEPLFRSW FSLLPLSHLV MYMENFIEHL GRFPAHILDC LSGIYYRLPG
860 870 880 890 900
LEQVLNTQDV QDVQNVQNIL EMLLRLLDTY RDKIPEEALS PSYLTVCLKL
910 920 930 940 950
HEAICSSTKL LKFYELPALS AEIVCRMIRL LSLVDSAGQR DETGNNSVQT
960 970 980 990 1000
VFQGTLAATK RWLREVFTKN MLTSSGASFT YVKEIEVWRR LVEIQFPAEH
1010 1020 1030 1040 1050
GWKESLLGDM EWRLTKEEPL SQITAYCNSC WDTKGLEDSV AKTFEKCIIE
1060 1070 1080 1090 1100
AVSSACQSQT SILQGFSYSD LRKFGIVLSA VITKSWPRTA DNFDDILKHL
1110 1120 1130 1140 1150
LTLADVKHVF RLCGTDEKIL ANVTEDAKRL IAVADSVLTK VVGDLLSGTI
1160 1170 1180 1190 1200
LVGQLELIIK HKNQFLDIWQ LREKSLSPQD EQCAVEEALD WRREELLLLK
1210 1220 1230 1240 1250
KEKRCVDSLL KMCGNVKHLI QVDFGVLAVR HSQDLSSKRL NDTVTVRLST
1260 1270 1280 1290 1300
SSNSQRATHY HLSSQVQEMA GKIDLLRDSH IFQLFWREAA EPLSEPKEDQ
1310 1320 1330 1340 1350
EAAELLSEPE EESERHILEL EEVYDYLYQP SYRKFIKLHQ DLKSGEVTLA
1360 1370 1380 1390 1400
EIDVIFKDFV NKYTDLDSEL KIMCTVDHQD QRDWIKDRVE QIKEYHHLHQ
1410 1420 1430 1440 1450
AVHAAKVILQ VKESLGLNGD FSVLNTLLNF TDNFDDFRRE TLDQINQELI
1460 1470 1480 1490 1500
QAKKLLQDIS EARCKGLQAL SLRKEFICWV REALGGINEL KVFVDLASIS
1510 1520 1530 1540 1550
AGENDIDVDR VACFHDAVQG YASLLFKLDP SVDFSAFMKH LKKLWKALDK
1560 1570 1580 1590 1600
DQYLPRKLCD SARNLEWLKT VNESHGSVER SSLTLATAIN QRGIYVIQAP
1610 1620 1630 1640 1650
KGGQKISPDT VLHLILPESP GSHEESREYS LEEVKELLNK LMLMSGKKDR
1660 1670 1680 1690 1700
NNTEVERFSE VFCSVQRLSQ AFIDLHSAGN MLFRTWIAMA YCSPKQGVSL
1710 1720 1730 1740 1750
QMDFGLDLVT ELKEGGDVTE LLAALCRQME HFLDSWKRFV TQKRMEHFYL
1760 1770 1780 1790 1800
NFYTAEQLVY LSTELRKQPP SDAALTMLSF IKSNCTLRDV LRASVGCGSE
1810 1820 1830 1840 1850
AARYRMRRVM EELPLMLLSE FSLVDKLRII MEQSMRCLPA FLPDCLDLET
1860 1870 1880 1890 1900
LGHCLAHLAG MGGSPVERCL PRGLQVGQPN LVVCGHSEVL PAALAVYMQT
1910 1920 1930 1940 1950
PSQPLPTYDE VLLCTPATTF EEVALLLRRC LTLGSLGHKV YSLLFADQLS
1960 1970 1980 1990 2000
YEVARQAEEL FHNLCTQQHR EDYQLVMVCD GDWEHCYLPS AFSQHKVFVT
2010 2020 2030 2040 2050
PQAPLEAIQA YLAGHYRVPK QTLSAAAVFN DRLCVGIVAS ERAGVGKSLY
2060 2070 2080 2090 2100
VKRLHDKMKM QLNVKNVPLK TIRLIDPQVD ESRVLGALLP FLDAQYQKVP
2110 2120 2130 2140 2150
VLFHLDVTSS VQTGIWVFLF KLLILQYLMD INGKMWLRNP CHLYIVEILE
2160 2170 2180 2190 2200
RRTSVPSRSS SALRTRVPQF SFLDIFPKVT CRPPKEVIDM ELSALRSDTE
2210 2220 2230 2240 2250
PGMDLWEFCS ETFQRPYQYL RRFNQNQDLD TFQYQEGSVE GTPEECLQHF
2260 2270 2280 2290 2300
LFHCGVINPS WSELRNFARF LNYQLRDCEA SLFCNPSFIG DTLRGFKKFV
2310 2320 2330 2340 2350
VTFMIFMARD FATPSLHTSD QSPGKHMVTM DGVREEDLAP FSLRKRWESE
2360 2370 2380 2390 2400
PHPYVFFNDD HTTMTFIGFH LQPNINGSVD AISHLTGKVI KRDVMTRDLY
2410 2420 2430 2440 2450
QGLLLQRVPF NVDFDKLPRH KKLERLCLTL GIPQATDPDK TYELTTDNML
2460 2470 2480 2490 2500
KILAIEMRFR CGIPVIIMGE TGCGKTRLIK FLSDLRRGGT NADTIKLVKV
2510 2520 2530 2540 2550
HGGTTADMIY SRVREAENVA FANKDQHQLD TILFFDEANT TEAISCIKEV
2560 2570 2580 2590 2600
LCDHMVDGQP LAEDSGLHII AACNPYRKHS EEMICRLESA GLGYRVSMEE
2610 2620 2630 2640 2650
TADRLGSIPL RQLVYRVHAL PPSLIPLVWD FGQLSDVAEK LYIQQIVQRL
2660 2670 2680 2690 2700
VESISLDENG TRVITEVLCA SQGFMRKTED ECSFVSLRDV ERCVKVFRWF
2710 2720 2730 2740 2750
HEHSAMLLAQ LNAFLSKSSV SKNHTERDPV LWSLMLAIGV CYHASLEKKD
2760 2770 2780 2790 2800
SYRKAIARFF PKPYDDSRLL LDEITRAQDL FLDGVPLRKT IAKNLALKEN
2810 2820 2830 2840 2850
VFMMVVCIEL KIPLFLVGKP GSSKSLAKTI VADAMQGPAA YSDLFRSLKQ
2860 2870 2880 2890 2900
VHLVSFQCSP HSTPQGIIST FRQCARFQQG KDLQQYVSVV VLDEVGLAED
2910 2920 2930 2940 2950
SPKMPLKTLH PLLEDGCIED DPAPHKKVGF VGISNWALDP AKMNRGIFVS
2960 2970 2980 2990 3000
RGSPNETELI ESAKGICSSD ILVQDRVQGY FASFAKAYET VCKRQDKEFF
3010 3020 3030 3040 3050
GLRDYYSLIK MVFAAAKASN RKPSPQDIAQ AVLRNFSGKD DIQALDIFLA
3060 3070 3080 3090 3100
NLPEAKCSEE VSPMQLIKQN IFGPSQKVPG GEQEDAESRY LLVLTKNYVA
3110 3120 3130 3140 3150
LQILQQTFFE GDQQPEIIFG SGFPKDQEYT QLCRNINRVK ICMETGKMVL
3160 3170 3180 3190 3200
LLNLQNLYES LYDALNQYYV HLGGQKYVDL GLGTHRVKCR VHPNFRLIVI
3210 3220 3230 3240 3250
EEKDVVYKHF PIPLINRLEK HYLDINTVLE KWQKSIVEEL CAWVEKFINV
3260 3270 3280 3290 3300
KAHHFQKRHK YSPSDVFIGY HSDACASVVL QVIERQGPRA LTEELHQKVS
3310 3320 3330 3340 3350
EEAKSILLNC ATPDAVVRLS AYSLGGFAAE WLSQEYFHRQ RHNSFADFLQ
3360 3370 3380 3390 3400
AHLHTADLER HAIFTEITTF SRLLTSHDCE ILESEVTGRA PKPTLLWLQQ
3410 3420 3430 3440 3450
FDTEYSFLKE VRNCLTNTAK CKILIFQTDF EDGIRSAQLI ASAKYSVINE
3460 3470 3480 3490 3500
INKIRENEDR IFVYFITKLS RVGRGTAYVG FHGGLWQSVH IDDLRRSTLM
3510 3520 3530 3540 3550
VSDVTRLQHV TISQLFAPGD LPELGLEHRA EDGHEEAMET EASTSGEVAE
3560 3570 3580 3590 3600
VAEEAMETES SEKVGKETSE LGGSDVSILD TTRLLRSCVQ SAVGMLRDQN
3610 3620 3630 3640 3650
ESCTRNMRRV VLLLGLLNED DACHASFLRV SKMRLSVFLK KQEESQFHPL
3660 3670 3680 3690 3700
EWLAREACNQ DALQEAGTFR HTLWKRVQGA VTPLLASMIS FIDRDGNLEL
3710 3720 3730 3740 3750
LTRPDTPPWA RDLWMFIFSD TMLLNIPLVM NNERHKGEMA YIVVQNHMNL
3760 3770 3780 3790 3800
SENASNNVPF SWKIKDYLEE LWVQAQYITD AEGLPKKFVD IFQQTPLGRF
3810 3820 3830 3840 3850
LAQLHGEPQQ ELLQCYLKDF ILLTMRVSTE EELKFLQMAL WSCTRKLKAA
3860 3870 3880 3890 3900
SEAPEEEVSL PWVHLAYQRF RSRLQNFSRI LTIYPQVLHS LMEARWNHEL
3910 3920 3930 3940 3950
AGCEMTLDAF AAMACTEMLT RNTLKPSPQA WLQLVKNLSM PLELICSDEH
3960 3970 3980 3990 4000
MQGSGSLAQA VIREVRAQWS RIFSTALFVE HVLLGTESRV PELQGLVTEH
4010 4020 4030 4040 4050
VFLLDKCLRE NSDVKTHGPF EAVMRTLCEC KETASKTLSR FGIQPCSICL
4060 4070 4080 4090 4100
GDAKDPVCLP CDHVHCLRCL RAWFASEQMI CPYCLTALPD EFSPAVSQAH
4110 4120 4130 4140 4150
REAIEKHARF RQMCNSFFVD LVSTICFKDN APPEKEVIES LLSLLFVQKG
4160 4170 4180 4190 4200
RLRDAAQRHC EHTKSLSPFN DVVDKTPVIR SVILKLLLKY SFHDVKDYIQ
4210 4220 4230 4240 4250
EYLTLLKKKA FITEDKTELY MLFINCLEDS ILEKTSAYSR NDELNHLEEE
4260 4270 4280 4290 4300
GRFLKAYSPA SRGREPANEA SVEYLQEVAR IRLCLDRAAD FLSEPEGGPE
4310 4320 4330 4340 4350
MAKEKQCYLQ QVKQFCIRVE NDWHRVYLVR KLSSQRGMEF VQGLSKPGRP
4360 4370 4380 4390 4400
HQWVFPKDVV KQQGLRQDHP GQMDRYLVYG DEYKALRDAV AKAVLECKPL
4410 4420 4430 4440 4450
GIKTALKACK TPQSQQSAYF LLTLFREVAI LYRSHNASLH PTPEQCEAVS
4460 4470 4480 4490 4500
KFIGECKILS PPDISRFATS LVDNSVPLLR AGPSDSNLDG TVTEMAIHAA
4510 4520 4530 4540 4550
AVLLCGQNEL LEPLKNLAFS PATMAHAFLP TMPEDLLAQA RRWKGLERVH
4560 4570 4580 4590 4600
WYTCPNGHPC SVGECGRPME QSICIDCHAP IGGIDHKPRD GFHLVKDKAD
4610 4620 4630 4640 4650
RTQTGHVLGN PQRRDVVTCD RGLPPVVFLL IRLLTHLALL LGASQSSQAL
4660 4670 4680 4690 4700
INIIKPPVRD PKGFLQQHIL KDLEQLAKML GHSADETIGV VHLVLRRLLQ
4710 4720 4730 4740 4750
EQHQLSSRRL LNFDTELSTK EMRNNWEKEI AAVISPELEH LDKTLPTMNN
4760 4770 4780 4790 4800
LISQDKRISS NPVAKIIYGD PVTFLPHLPR KSVVHCSKIW SCRKRITVEY
4810 4820 4830 4840 4850
LQHIVEQKNG KERVPILWHF LQKEAELRLV KFLPEILALQ RDLVKQFQNV
4860 4870 4880 4890 4900
QQVEYSSIRG FLSKHSSDGL RQLLHNRITV FLSTWNKLRR SLETNGEINL
4910 4920 4930 4940 4950
PKDYCSTDLD LDTEFEILLP RRRGLGLCAT ALVSYLIRLH NEIVYAVEKL
4960 4970 4980 4990 5000
SKENNSYSVD AAEVTELHVI SYEVERDLTP LILSNCQYQV EEGRETVQEF
5010 5020 5030 5040 5050
DLEKIQRQIV SRFLQGKPRL SLKGIPTLVY RHDWNYEHLF MDIKNKMAQD
5060 5070 5080 5090 5100
SLPSSVISAI SGQLQSYSDA CEVLSVVEVT LGFLSTAGGD PNMQLNVYTQ
5110 5120 5130 5140 5150
DILQMGDQTI HVLKALNRCQ LKHTIALWQF LSAHKSEQLL RLHKEPFGEI
5160 5170 5180 5190 5200
SSRYKADLSP ENAKLLSTFL NQTGLDAFLL ELHEMIILKL KNPQTQTEER
5210 5220 5230 5240 5250
FRPQWSLRDT LVSYMQTKES EILPEMASQF PEEILLASCV SVWKTAAVLK

WNREMR
Length:5,256
Mass (Da):596,487
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC42E9F881CADA18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q63HN8RN213_HUMAN
E3 ubiquitin-protein ligase RNF213
RNF213 ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR
5,207Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTR7A0A0A0MTR7_HUMAN
E3 ubiquitin-protein ligase RNF213
RNF213
5,207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3H9I3L3H9_HUMAN
E3 ubiquitin-protein ligase RNF213
RNF213
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC123764 Genomic DNA No translation available.
AC124319 Genomic DNA No translation available.
KC877677 Genomic DNA No translation available.
KF510430 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_005257602.2, XM_005257545.4
XP_005257603.2, XM_005257546.4
XP_006722058.1, XM_006721995.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.195642
Hs.740662
Hs.745415

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000508628; ENSP00000425956; ENSG00000173821

Database of genes from NCBI RefSeq genomes

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GeneIDi
57674

UCSC genome browser

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UCSCi
uc060ldc.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123764 Genomic DNA No translation available.
AC124319 Genomic DNA No translation available.
KC877677 Genomic DNA No translation available.
KF510430 Genomic DNA No translation available.
RefSeqiXP_005257602.2, XM_005257545.4
XP_005257603.2, XM_005257546.4
XP_006722058.1, XM_006721995.3
UniGeneiHs.195642
Hs.740662
Hs.745415

3D structure databases

ProteinModelPortaliA0A0A0MTC1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

jPOSTiA0A0A0MTC1
PeptideAtlasiA0A0A0MTC1
PRIDEiA0A0A0MTC1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000508628; ENSP00000425956; ENSG00000173821
GeneIDi57674
UCSCiuc060ldc.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57674
EuPathDBiHostDB:ENSG00000173821.19
HGNCiHGNC:14539 RNF213
OpenTargetsiENSG00000173821

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00630000089884
OMAiSARHLEW
OrthoDBi840at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RNF213 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57674

Gene expression databases

BgeeiENSG00000173821 Expressed in 193 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiA0A0A0MTC1 baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR031248 RNF213
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR22605 PTHR22605, 1 hit
PfamiView protein in Pfam
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A0MTC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A0MTC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: January 16, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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