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Protein

Immunoglobulin kappa joining 1

Gene

IGKJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

Caution

There are several genes encoding the J region in the immunoglobulin kappa locus. The peptide described in this entry is a representative for all the peptides encoded by these genes. For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Protein family/group databases

IMGT/GENE-DBIGKJ1

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin kappa joining 12 Publications
Gene namesi
Name:IGKJ12 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000211597.2
HGNCiHGNC:5719 IGKJ1
neXtProtiNX_A0A0A0MT89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000439095‹1 – ›12Immunoglobulin kappa joining 1Add BLAST›12

Expressioni

Gene expression databases

BgeeiENSG00000211597

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Sequencei

Sequence statusi: Complete.

Length:12
Mass (Da):1,394
Last modified:April 25, 2018 - v2
Checksum:iC1FDC5450821A866
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei121

Polymorphismi

The sequence shown is that of IMGT allele IGKJ1*01.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244205 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000390242; ENSP00000419111; ENSG00000211597
UCSCiuc061lqh.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKJ01_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MT89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: April 25, 2018
Last modified: April 25, 2018
This is version 14 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

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