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Protein

Cysteine protease

Gene

ATG4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation
Biological processAutophagyUniRule annotationSAAS annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteaseUniRule annotation (EC:3.4.22.-UniRule annotation)
Gene namesi
Name:ATG4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101844.17
HGNCiHGNC:16489 ATG4A

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101844

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0A0MT61

Expressioni

Gene expression databases

BgeeiENSG00000101844 Expressed in 213 organ(s), highest expression level in biceps brachii
ExpressionAtlasiA0A0A0MT61 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MT61
SMRiA0A0A0MT61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C54 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2674 Eukaryota
ENOG410XPQ0 LUCA
GeneTreeiENSGT00530000063000

Family and domain databases

InterProiView protein in InterPro
IPR033474 ATG4A
IPR038765 Papain_like_cys_pep_sf
IPR005078 Peptidase_C54
PANTHERiPTHR22624 PTHR22624, 1 hit
PTHR22624:SF35 PTHR22624:SF35, 1 hit
PfamiView protein in Pfam
PF03416 Peptidase_C54, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MT61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRCGQMMLA QALICRHLGR DWSWEKQKEQ PKEYQRILQC FLDRKDCCYS
60 70 80 90 100
IHQMAQMGVG EGKSIGEWFG PNTVAQVLKK LALFDEWNSL AVYVSMDNTV
110 120 130 140 150
VIEDIKKMCR VLPLSADTAG DRPPDSLTAS NQSKGTSAYC SAWKPLLLIV
160 170 180 190 200
PLRLGINQIN PVYVDAFKEC FKMPQSLGAL GGKPNNAYYF IGFLGDELIF

LD
Length:202
Mass (Da):22,765
Last modified:January 7, 2015 - v1
Checksum:i0932C8F7D2DF471F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WYN0ATG4A_HUMAN
Cysteine protease ATG4A
ATG4A APG4A, AUTL2
398Annotation score:
G5E979G5E979_HUMAN
Cysteine protease
ATG4A hCG_21686
231Annotation score:
H7BYM2H7BYM2_HUMAN
Cysteine protease
ATG4A
312Annotation score:
F8W7J2F8W7J2_HUMAN
Cysteine protease ATG4A
ATG4A
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei202Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031177 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000457035; ENSP00000416218; ENSG00000101844
UCSCiuc065apz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031177 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0A0MT61
SMRiA0A0A0MT61
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0A0MT61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457035; ENSP00000416218; ENSG00000101844
UCSCiuc065apz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000101844.17
HGNCiHGNC:16489 ATG4A
OpenTargetsiENSG00000101844
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2674 Eukaryota
ENOG410XPQ0 LUCA
GeneTreeiENSGT00530000063000

Gene expression databases

BgeeiENSG00000101844 Expressed in 213 organ(s), highest expression level in biceps brachii
ExpressionAtlasiA0A0A0MT61 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033474 ATG4A
IPR038765 Papain_like_cys_pep_sf
IPR005078 Peptidase_C54
PANTHERiPTHR22624 PTHR22624, 1 hit
PTHR22624:SF35 PTHR22624:SF35, 1 hit
PfamiView protein in Pfam
PF03416 Peptidase_C54, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0MT61_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MT61
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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