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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

FDXR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80FAD; via amide nitrogenUniRule annotation1
Binding sitei100FADUniRule annotation1
Binding sitei108FAD; via amide nitrogenUniRule annotation1
Binding sitei144FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei271NADPUniRule annotation1
Binding sitei429FAD; via amide nitrogenUniRule annotation1
Binding sitei436NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi215 – 218NADPUniRule annotation4
Nucleotide bindingi259 – 260NADPUniRule annotation2
Nucleotide bindingi436 – 438FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:FDXRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161513.11
HGNCiHGNC:3642 FDXR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161513

PTM / Processingi

Proteomic databases

EPDiA0A0A0MSZ4
PeptideAtlasiA0A0A0MSZ4
PRIDEiA0A0A0MSZ4

Expressioni

Gene expression databases

BgeeiENSG00000161513 Expressed in 156 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiA0A0A0MSZ4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MSZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 226Pyr_redox_2InterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000013574

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MSZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRCWRWWG WSAWPRTRLP PAGSTPTFGG SDEVRDPANA KALRNKRRRM
60 70 80 90 100
QVRVKLGKFQ LLLDIQEKTP QICVVGSGPA GFYTAQHLLK HPQAHVDIYE
110 120 130 140 150
KQPVPFGLVR FGVAPDHPEV KNVINTFTQT AHSGRCAFWG NVEVGRDVTV
160 170 180 190 200
PELQEAYHAV VLSYGAEDHR ALEIPGEELP GVCSARAFVG WYNGLPENQE
210 220 230 240 250
LEPDLSCDTA VILGQGNVAL DVARILLTPP EHLERTDITK AALGVLRQSR
260 270 280 290 300
VKTVWLVGRR GPLQVAFTIK ELREMIQLPG ARPILDPVDF LGLQDKIKEV
310 320 330 340 350
PRPRKRLTEL LLRTATEKPG PAEAARQASA SRAWGLRFFR SPQQVLPSPD
360 370 380 390 400
GRRAAGVRLA VTRLEGVDEA TRAVPTGDME DLPCGLVLSS IGYKSRPVDP
410 420 430 440 450
SVPFDSKLGV IPNVEGRVMD VPGLYCSGWV KRGPTGVIAT TMTDSFLTGQ
460 470 480 490 500
MLLQDLKAGL LPSGPRPGYA AIQALLSSRG VRPVSFSDWE KLDAEEVARG
510 520
QGTGKPREKL VDPQEMLRLL GH
Length:522
Mass (Da):57,342
Last modified:January 7, 2015 - v1
Checksum:i8DD435A53127363B
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P22570ADRO_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR ADXR
491Annotation score:
A0A0A0MT64A0A0A0MT64_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
534Annotation score:
A0A0C4DFN8A0A0C4DFN8_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
491Annotation score:
A0A0A0MTN9A0A0A0MTN9_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
439Annotation score:
A0A0A0MTR6A0A0A0MTR6_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
483Annotation score:
A0A0C4DGN7A0A0C4DGN7_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
497Annotation score:
J3QQX3J3QQX3_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
463Annotation score:
J3KS64J3KS64_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
91Annotation score:
J3QKZ8J3QKZ8_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
164Annotation score:
J3QQW7J3QQW7_HUMAN
NADPH:adrenodoxin oxidoreductase, m...
FDXR
178Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087651 Genomic DNA No translation available.
RefSeqiNP_001244942.2, NM_001258013.3
UniGeneiHs.69745

Genome annotation databases

EnsembliENST00000413947; ENSP00000408595; ENSG00000161513
GeneIDi2232
UCSCiuc010wrk.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087651 Genomic DNA No translation available.
RefSeqiNP_001244942.2, NM_001258013.3
UniGeneiHs.69745

3D structure databases

ProteinModelPortaliA0A0A0MSZ4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiA0A0A0MSZ4
PeptideAtlasiA0A0A0MSZ4
PRIDEiA0A0A0MSZ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000413947; ENSP00000408595; ENSG00000161513
GeneIDi2232
UCSCiuc010wrk.3 human

Organism-specific databases

CTDi2232
EuPathDBiHostDB:ENSG00000161513.11
HGNCiHGNC:3642 FDXR
OpenTargetsiENSG00000161513
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000013574

Miscellaneous databases

GenomeRNAii2232

Gene expression databases

BgeeiENSG00000161513 Expressed in 156 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiA0A0A0MSZ4 baseline and differential

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0MSZ4_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MSZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: October 10, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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