UniProtKB - A0A0A0MSU4 (A0A0A0MSU4_HUMAN)
Protein
Submitted name:
ATP-binding cassette sub-family A member 8
Gene
ABCA8
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 516 – 523 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1318 – 1325 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette sub-family A member 8Imported |
Gene namesi | Name:ABCA8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141338.13 |
HGNCi | HGNC:38, ABCA8 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 265 – 288 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 294 – 320 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 332 – 353 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 359 – 377 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 397 – 419 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 862 – 879 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 1021 – 1044 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1064 – 1086 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1098 – 1123 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1135 – 1157 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1164 – 1186 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1198 – 1220 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | A0A0A0MSU4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 480 – 715 | ABC transporterInterPro annotationAdd BLAST | 236 | |
Domaini | 1280 – 1513 | ABC transporterInterPro annotationAdd BLAST | 234 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000162012 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MSU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKRKISVCQ QTWALLCKNF LKKWRMKRES LMEWLNSLLL LLCLYIYPHS
60 70 80 90 100
HQVNDFSSLL TMDLGRVDTF NESRFSVVYT PVTNTTQQIM NKVASTPFLA
110 120 130 140 150
GKEVLGLPDE ESIKEFTANY PEEIVRVTFT NTYSYHLKFL LGHGMPAKKE
160 170 180 190 200
HKDHTAHCYE TNEDVYCEVS VFWKEGFVAL QAAINAAIIE ITTNHSVMEE
210 220 230 240 250
LMSVTGKNMK MHSFIGQSGV ITDLYLFSCI ISFSSFIYYA SVNVTRERKR
260 270 280 290 300
MKALMTMMGL RDSAFWLSWG LLYAGFIFIM ALFLALVIRS TQFIILSGFM
310 320 330 340 350
VVFSLFLLYG LSLVALAFLM SILVKKSFLT GLVVFLLTVF WGCLGFTSLY
360 370 380 390 400
RHLPASLEWI LSLLSPFAFM LGMAQLLHLD YDLNSNAFPH PSDGSNLIVA
410 420 430 440 450
TNFMLAFDTC LYLALAIYFE KILPNEYGHR RPPLFFLKSS FWSQTQKTDH
460 470 480 490 500
VALEDEMDAD PSFHDSFEQA PPEFQGKEAI RIRNVTKEYK GKPDKIEALK
510 520 530 540 550
DLVFDIYEGQ ITAILGHSGA GKSTLLNILS GLSVPTKGSV TIYNNKLSEM
560 570 580 590 600
ADLENLSKLT GVCPQSNVQF DFLTVRENLR LFAKIKGILP QEVDKEIQRV
610 620 630 640 650
LLELEMKNIQ DVLAQNLSGG QKRKLTFGIA ILGDPQIFLL DEPTAGLDPF
660 670 680 690 700
SRHQVWNLLK ERKTDRVILF STQFMDEADI LADRKVFLSQ GKLKCAGSSL
710 720 730 740 750
FLKKKWGIGY HLSLQLNEIC VEENITSLVK QHIPDAKLSA KSEGKLIYTL
760 770 780 790 800
PLERTNKFPE LYKDLDSYPD LGIENYGVSM TTLNEVFLKL EGKSTINESD
810 820 830 840 850
IAILGEVQAE KADDTERLVE MEQVLSSLNK MRKTIGGVAL WRQQICAIAR
860 870 880 890 900
VRLLKLKHER KALLALLLIL MAGFCPLLVE YTMVKIYQNS YTWELSPHLY
910 920 930 940 950
FLAPGQQPHD PLTQLLIINK TGASIDDFIQ SVEHQNIALE VDAFGTRNGT
960 970 980 990 1000
DDPSYNGAIT VCCNEKNYSF SLACNAKRLN CFPVLMDIVS NGLLGMVKPS
1010 1020 1030 1040 1050
VHIRTERSTF LENGQDNPIG FLAYIMFWLV LTSSCPPYIA MSSIDDYKNR
1060 1070 1080 1090 1100
ARSQLRISGL SPSAYWFGQA LVDVSLYFLV FVFIYLMSYI SNFEDMLLTI
1110 1120 1130 1140 1150
IHIIQIPCAV GYSFSLIFMT YVISFIFRKG RKNSGIWSFC FYVVTVFSVA
1160 1170 1180 1190 1200
GFAFSIFESD IPFIFTFLIP PATMIGCLFL SSHLLFSSLF SEERMDVQPF
1210 1220 1230 1240 1250
LVFLIPFLHF IIFLFTLRCL EWKFGKKSMR KDPFFSSDVC QNPEEPEGED
1260 1270 1280 1290 1300
EDVQMERVRT ANALNSTNFD EKPVIIASCL RKEYAGKRKG CFSKRKNKIA
1310 1320 1330 1340 1350
TRNVSFCVRK GEVLGLLGHN GAGKSTSIKV ITGDTKPTAG QVLLKGSGGG
1360 1370 1380 1390 1400
DALEFLGYCP QENALWPNLT VRQHLEVYAA VKGLRKGDAE VAITRLVDAL
1410 1420 1430 1440 1450
KLQDQLKSPV KTLSEGIKRK LCFVLSILGN PSVVLLDEPS TGMDPEGQQQ
1460 1470 1480 1490 1500
MWQAIRATFR NTERGALLTT HYMAEAEAVC DRVAIMVSGR LRCIGSIQHL
1510 1520 1530 1540 1550
KSKFGKDYLL EMKVKNLAQV EPLHAEILRL FPQAARQERY SSLMVYKLPV
1560 1570 1580 1590 1600
EDVQPLAQAF FKLEKVKQSF DLEEYSLSQS TLEQVFLELS KEQELGDFEE
1610
DFDPSVKWKL LPQEEP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO94911 | ABCA8_HUMAN | ATP-binding cassette sub-family A m... | ABCA8 KIAA0822 | 1,581 | Annotation score: | ||
A0A075B774 | A0A075B774_HUMAN | ATP-binding cassette sub-family A m... | ABCA8 | 702 | Annotation score: | ||
Q49AI9 | Q49AI9_HUMAN | ABCA8 protein | ABCA8 | 156 | Annotation score: | ||
K7ELK9 | K7ELK9_HUMAN | ATP-binding cassette sub-family A m... | ABCA8 | 115 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005922 Genomic DNA No translation available. AC015844 Genomic DNA No translation available. |
RefSeqi | NP_001275915.1, NM_001288986.1 |
Genome annotation databases
Ensembli | ENST00000430352; ENSP00000402814; ENSG00000141338 |
GeneIDi | 10351 |
UCSCi | uc010wqq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005922 Genomic DNA No translation available. AC015844 Genomic DNA No translation available. |
RefSeqi | NP_001275915.1, NM_001288986.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A0A0MSU4 |
Protocols and materials databases
Antibodypediai | 31802, 130 antibodies |
Genome annotation databases
Ensembli | ENST00000430352; ENSP00000402814; ENSG00000141338 |
GeneIDi | 10351 |
UCSCi | uc010wqq.4, human |
Organism-specific databases
CTDi | 10351 |
EuPathDBi | HostDB:ENSG00000141338.13 |
HGNCi | HGNC:38, ABCA8 |
OpenTargetsi | ENSG00000141338 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162012 |
Miscellaneous databases
BioGRID-ORCSi | 10351, 4 hits in 845 CRISPR screens |
ChiTaRSi | ABCA8, human |
GenomeRNAii | 10351 |
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | A0A0A0MSU4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MSU4_HUMAN | |
Accessioni | A0A0A0MSU4Primary (citable) accession number: A0A0A0MSU4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | December 2, 2020 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |