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UniProtKB - A0A0A0MSU1 (A0A0A0MSU1_HUMAN)
Protein
Submitted name:
Protein CBFA2T1
Gene
RUNX1T1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription corepressor activity Source: InterPro
GO - Biological processi
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | RepressorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Protein CBFA2T1 |
Gene namesi | Name:RUNX1T1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1535, RUNX1T1 |
VEuPathDBi | HostDB:ENSG00000079102 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000079102, Expressed in forebrain and 240 other tissues |
ExpressionAtlasi | A0A0A0MSU1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 179 – 274 | TAFHInterPro annotationAdd BLAST | 96 | |
Domaini | 574 – 610 | MYND-typeInterPro annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 88 – 173 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 289 – 357 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 460 – 482 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 616 – 663 | DisorderedSequence analysisAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 513 – 555 | Sequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 124 – 173 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 294 – 322 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 329 – 346 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the CBFA2T family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000183176 |
OrthoDBi | 334242at2759 |
Family and domain databases
Gene3Di | 1.20.120.1110, 1 hit |
InterProi | View protein in InterPro IPR013290, CBFA2T1 IPR013289, CBFA2T1/2/3 IPR014896, NHR2 IPR037249, TAFH/NHR1_dom_sf IPR003894, TAFH_NHR1 IPR002893, Znf_MYND |
PANTHERi | PTHR10379, PTHR10379, 1 hit PTHR10379:SF5, PTHR10379:SF5, 1 hit |
Pfami | View protein in Pfam PF08788, NHR2, 1 hit PF07531, TAFH, 1 hit PF01753, zf-MYND, 1 hit |
PRINTSi | PR01875, ETOFAMILY PR01876, MTG8PROTEIN |
SMARTi | View protein in SMART SM00549, TAFH, 1 hit |
SUPFAMi | SSF158553, SSF158553, 1 hit |
PROSITEi | View protein in PROSITE PS51119, TAFH, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 28 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MSU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCHPDKAFTS DKLQCVFNEY KAAVWVPPRP RPLSRAPLPE AGGENLHLKI
60 70 80 90 100
SRVRKRNLPF VVWGEEEAST PGLDAISHHL CYPDRTHRDR TEKHSTMPDS
110 120 130 140 150
PVDVKTQSRL TPPTMPPPPT TQGAPRTSSF TPTTLTNGTS HSPTALNGAP
160 170 180 190 200
SPPNGFSNGP SSSSSSSLAN QQLPPACGAR QLSKLKRFLT TLQQFGNDIS
210 220 230 240 250
PEIGERVRTL VLGLVNSTLT IEEFHSKLQE ATNFPLRPFV IPFLKANLPL
260 270 280 290 300
LQRELLHCAR LAKQNPAQYL AQHEQLLLDA STTSPVDSSE LLLDVNENGK
310 320 330 340 350
RRTPDRTKEN GFDREPLHSE HPSKRPCTIS PGQRYSPNNG LSYQPNGLPH
360 370 380 390 400
PTPPPPQHYR LDDMAIAHHY RDSYRHPSHR DLRDRNRPMG LHGTRQEEMI
410 420 430 440 450
DHRLTDREWA EEWKHLDHLL NCIMDMVEKT RRSLTVLRRC QEADREELNY
460 470 480 490 500
WIRRYSDAED LKKGGGSSSS HSRQQSPVNP DPVALDAHRE FLHRPASGYV
510 520 530 540 550
PEEIWKKAEE AVNEVKRQAM TELQKAVSEA ERKAHDMITT ERAKMERTVA
560 570 580 590 600
EAKRQAAEDA LAVINQQEDS SESCWNCGRK ASETCSGCNT ARYCGSFCQH
610 620 630 640 650
KDWEKHHHIC GQTLQAQQQG DTPAVSSSVT PNSGAGSPMD TPPAATPRST
660
TPGTPSTIET TPR
Computationally mapped potential isoform sequencesi
There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ06455 | MTG8_HUMAN | Protein CBFA2T1 | RUNX1T1 AML1T1, CBFA2T1, CDR, ETO, MTG8 | 604 | Annotation score: | ||
A0A087WWT6 | A0A087WWT6_HUMAN | Protein CBFA2T1 | RUNX1T1 hCG_20715 | 584 | Annotation score: | ||
E5RG85 | E5RG85_HUMAN | Protein CBFA2T1 | RUNX1T1 | 171 | Annotation score: | ||
E5RHJ8 | E5RHJ8_HUMAN | Protein CBFA2T1 | RUNX1T1 | 210 | Annotation score: | ||
E7ETA8 | E7ETA8_HUMAN | Protein CBFA2T1 | RUNX1T1 | 229 | Annotation score: | ||
E5RH30 | E5RH30_HUMAN | Protein CBFA2T1 | RUNX1T1 | 120 | Annotation score: | ||
E7EWJ9 | E7EWJ9_HUMAN | Protein CBFA2T1 | RUNX1T1 | 169 | Annotation score: | ||
E7EQW3 | E7EQW3_HUMAN | Protein CBFA2T1 | RUNX1T1 | 156 | Annotation score: | ||
E5RH72 | E5RH72_HUMAN | Protein CBFA2T1 | RUNX1T1 | 46 | Annotation score: | ||
E5RI38 | E5RI38_HUMAN | Protein CBFA2T1 | RUNX1T1 | 79 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC103680 Genomic DNA No translation available. AC104339 Genomic DNA No translation available. AF181450 Genomic DNA No translation available. KF458797 Genomic DNA No translation available. |
RefSeqi | NP_001185608.1, NM_001198679.1 |
Genome annotation databases
Ensembli | ENST00000436581.6; ENSP00000402257.3; ENSG00000079102.16 |
GeneIDi | 862 |
UCSCi | uc022axs.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC103680 Genomic DNA No translation available. AC104339 Genomic DNA No translation available. AF181450 Genomic DNA No translation available. KF458797 Genomic DNA No translation available. |
RefSeqi | NP_001185608.1, NM_001198679.1 |
3D structure databases
SMRi | A0A0A0MSU1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A0A0MSU1 |
Protocols and materials databases
Antibodypediai | 25672, 282 antibodies from 34 providers |
DNASUi | 862 |
Genome annotation databases
Ensembli | ENST00000436581.6; ENSP00000402257.3; ENSG00000079102.16 |
GeneIDi | 862 |
UCSCi | uc022axs.1, human |
Organism-specific databases
CTDi | 862 |
HGNCi | HGNC:1535, RUNX1T1 |
OpenTargetsi | ENSG00000079102 |
VEuPathDBi | HostDB:ENSG00000079102 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183176 |
OrthoDBi | 334242at2759 |
Miscellaneous databases
BioGRID-ORCSi | 862, 15 hits in 1080 CRISPR screens |
ChiTaRSi | RUNX1T1, human |
GenomeRNAii | 862 |
Gene expression databases
Bgeei | ENSG00000079102, Expressed in forebrain and 240 other tissues |
ExpressionAtlasi | A0A0A0MSU1, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.1110, 1 hit |
InterProi | View protein in InterPro IPR013290, CBFA2T1 IPR013289, CBFA2T1/2/3 IPR014896, NHR2 IPR037249, TAFH/NHR1_dom_sf IPR003894, TAFH_NHR1 IPR002893, Znf_MYND |
PANTHERi | PTHR10379, PTHR10379, 1 hit PTHR10379:SF5, PTHR10379:SF5, 1 hit |
Pfami | View protein in Pfam PF08788, NHR2, 1 hit PF07531, TAFH, 1 hit PF01753, zf-MYND, 1 hit |
PRINTSi | PR01875, ETOFAMILY PR01876, MTG8PROTEIN |
SMARTi | View protein in SMART SM00549, TAFH, 1 hit |
SUPFAMi | SSF158553, SSF158553, 1 hit |
PROSITEi | View protein in PROSITE PS51119, TAFH, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MSU1_HUMAN | |
Accessioni | A0A0A0MSU1Primary (citable) accession number: A0A0A0MSU1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | May 25, 2022 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |