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Protein
Submitted name:

DNA-binding protein Ikaros

Gene

IKZF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
DNA-binding protein IkarosImported
Gene namesi
Name:IKZF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000185811.16
HGNCiHGNC:13176 IKZF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185811

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0A0MST1

Expressioni

Gene expression databases

BgeeiENSG00000185811 Expressed in 184 organ(s), highest expression level in leukocyte
ExpressionAtlasiA0A0A0MST1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MST1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 259C2H2-typeInterPro annotationAdd BLAST21

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074392

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

A0A0A0MST1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDADEGQDMS QVSVIKEETN HSEMAEDLCK IGSERSLVLD RLASNVAKRK
60 70 80 90 100
SSMPQKFLGD KGLSDTPYDS SASYEKENEM MKSHVMDQAI NNAINYLGAE
110 120 130 140 150
SLRPLVQTPP GGSEVVPVIS PMYQLHKPLA EGTPRSNHSA QDSAVENLLL
160 170 180 190 200
LSKAKLVPSE REASPSNSCQ DSTDTESNNE EQRSGLIYLT NHIAPHARNG
210 220 230 240 250
LSLKEEHRAY DLLRAASENS QDALRVVSTS GEQMKVYKCE HCRVLFLDHV
260 270 280 290
MYTIHMGCHG FRDPFECNMC GYHSQDRYEF SSHITRGEHR FHMS
Length:294
Mass (Da):32,922
Last modified:January 7, 2015 - v1
Checksum:iEBE5F9D4F2DE2249
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13422IKZF1_HUMAN
DNA-binding protein Ikaros
IKZF1 IK1, IKAROS, LYF1, ZNFN1A1
519Annotation score:
R9R4D9R9R4D9_HUMAN
DNA-binding protein Ikaros
IKZF1
268Annotation score:
A0A0A0MRA0A0A0A0MRA0_HUMAN
DNA-binding protein Ikaros
IKZF1
249Annotation score:
A0A087WU46A0A087WU46_HUMAN
DNA-binding protein Ikaros
IKZF1
336Annotation score:
Q3T907Q3T907_HUMAN
DNA-binding protein Ikaros
IKZF1 ZNFN1A1
67Annotation score:
A0A2R8Y4T7A0A2R8Y4T7_HUMAN
DNA-binding protein Ikaros
IKZF1
170Annotation score:
C9JTB0C9JTB0_HUMAN
DNA-binding protein Ikaros
IKZF1
174Annotation score:
A0A2R8Y4D3A0A2R8Y4D3_HUMAN
DNA-binding protein Ikaros
IKZF1
77Annotation score:
A0A2R8YFR0A0A2R8YFR0_HUMAN
DNA-binding protein Ikaros
IKZF1
67Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124014 Genomic DNA No translation available.
AC233268 Genomic DNA No translation available.
AUXG01000057 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000440768; ENSP00000401507; ENSG00000185811
UCSCiuc022acr.2 human

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MST1_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MST1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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