UniProtKB - A0A0A0MSN4 (A0A0A0MSN4_HUMAN)
Protein
Angiotensin-converting enzyme
Gene
ACE
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation
GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
- peptidyl-dipeptidase activity Source: InterPro
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACEImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2707, ACE |
VEuPathDBi | HostDB:ENSG00000159640.15 |
Subcellular locationi
Other locations
- membrane Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5001974473 | 30 – 1242 | Angiotensin-converting enzymeSequence analysisAdd BLAST | 1213 |
Keywords - PTMi
GlycoproteinUniRule annotationProteomic databases
PeptideAtlasi | A0A0A0MSN4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | A0A0A0MSN4, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_006219_0_0_1 |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MSN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAASGRRGP GLLLPLPLLL LLPPQPALAL DPGLQPGNFS ADEAGAQLFA
60 70 80 90 100
QSYNSSAEQV LFQSVAASWA HDTNITAENA RRQEEAALLS QEFAEAWGQK
110 120 130 140 150
AKELYEPIWQ NFTDPQLRRI IGAVRTLGSA NLPLAKRQQY NALLSNMSRI
160 170 180 190 200
YSTAKVCLPN KTATCWSLDP DLTNILASSR SYAMLLFAWE GWHNAAGIPL
210 220 230 240 250
KPLYEDFTAL SNEAYKQDGF TDTGAYWRSW YNSPTFEDDL EHLYQQLEPL
260 270 280 290 300
YLNLHAFVRR ALHRRYGDRY INLRGPIPAH LLGDMWAQSW ENIYDMVVPF
310 320 330 340 350
PDKPNLDVTS TMLQQGWNAT HMFRVAEEFF TSLELSPMPP EFWEGSMLEK
360 370 380 390 400
PADGREVVCH ASAWDFYNRK DFRIKQCTRV TMDQLSTVHH EMGHIQYYLQ
410 420 430 440 450
YKDLPVSLRR GANPGFHEAI GDVLALSVST PEHLHKIGLL DRVTNDTESD
460 470 480 490 500
INYLLKMALE KIAFLPFGYL VDQWRWGVFS GRTPPSRYNF DWWYLRTKYQ
510 520 530 540 550
GICPPVTRNE THFDAGAKFH VPNVTPYIRY FVSFVLQFQF HEALCKEAGY
560 570 580 590 600
EGPLHQCDIY RSTKAGAKLR KVLQAGSSRP WQEVLKDMVG LDALDAQPLL
610 620 630 640 650
KYFQPVTQWL QEQNQQNGEV LGWPEYQWHP PLPDNYPEGI DLVTDEAEAS
660 670 680 690 700
KFVEEYDRTS QVVWNEYAEA NWNYNTNITT ETSKILLQKN MQIANHTLKY
710 720 730 740 750
GTQARKFDVN QLQNTTIKRI IKKVQDLERA ALPAQELEEY NKILLDMETT
760 770 780 790 800
YSVATVCHPN GSCLQLEPDL TNVMATSRKY EDLLWAWEGW RDKAGRAILQ
810 820 830 840 850
FYPKYVELIN QAARLNGYVD AGDSWRSMYE TPSLEQDLER LFQELQPLYL
860 870 880 890 900
NLHAYVRRAL HRHYGAQHIN LEGPIPAHLL GNMWAQTWSN IYDLVVPFPS
910 920 930 940 950
APSMDTTEAM LKQGWTPRRM FKEADDFFTS LGLLPVPPEF WNKSMLEKPT
960 970 980 990 1000
DGREVVCHAS AWDFYNGKDF RIKQCTTVNL EDLVVAHHEM GHIQYFMQYK
1010 1020 1030 1040 1050
DLPVALREGA NPGFHEAIGD VLALSVSTPK HLHSLNLLSS EGGSDEHDIN
1060 1070 1080 1090 1100
FLMKMALDKI AFIPFSYLVD QWRWRVFDGS ITKENYNQEW WSLRLKYQGL
1110 1120 1130 1140 1150
CPPVPRTQGD FDPGAKFHIP SSVPYIRYFV SFIIQFQFHE ALCQAAGHTG
1160 1170 1180 1190 1200
PLHKCDIYQS KEAGQRLATA MKLGFSRPWP EAMQLITGQP NMSASAMLSY
1210 1220 1230 1240
FKPLLDWLRT ENELHGEKLG WPQYNWTPNS GTATHPTSSL GS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12821 | ACE_HUMAN | Angiotensin-converting enzyme | ACE DCP, DCP1 | 1,306 | Annotation score: | ||
J3KS28 | J3KS28_HUMAN | Angiotensin-converting enzyme | ACE | 314 | Annotation score: | ||
J3KTB8 | J3KTB8_HUMAN | Angiotensin-converting enzyme | ACE | 282 | Annotation score: | ||
J3KSQ5 | J3KSQ5_HUMAN | Angiotensin-converting enzyme | ACE | 208 | Annotation score: | ||
J3KRH5 | J3KRH5_HUMAN | Angiotensin-converting enzyme | ACE | 145 | Annotation score: | ||
J3KTH9 | J3KTH9_HUMAN | Angiotensin-converting enzyme | ACE | 168 | Annotation score: | ||
J3QLR4 | J3QLR4_HUMAN | Angiotensin-converting enzyme | ACE | 119 | Annotation score: | ||
J3QRX8 | J3QRX8_HUMAN | Angiotensin-converting enzyme | ACE | 138 | Annotation score: | ||
J3QSC7 | J3QSC7_HUMAN | Angiotensin-converting enzyme | ACE | 36 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000428043; ENSP00000397593; ENSG00000159640 |
UCSCi | uc031rdj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0A0MSN4 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A0A0MSN4 |
Protocols and materials databases
Antibodypediai | 31288, 832 antibodies |
Genome annotation databases
Ensembli | ENST00000428043; ENSP00000397593; ENSG00000159640 |
UCSCi | uc031rdj.1, human |
Organism-specific databases
HGNCi | HGNC:2707, ACE |
OpenTargetsi | ENSG00000159640 |
VEuPathDBi | HostDB:ENSG00000159640.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_006219_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACE, human |
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | A0A0A0MSN4, baseline and differential |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MSN4_HUMAN | |
Accessioni | A0A0A0MSN4Primary (citable) accession number: A0A0A0MSN4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | February 10, 2021 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |