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UniProtKB - A0A0A0MSH9 (A0A0A0MSH9_HUMAN)
Protein
Submitted name:
Chromodomain-helicase-DNA-binding protein 1-like
Gene
CHD1L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA helicase activity Source: InterPro
- hydrolase activity Source: UniProtKB-KW
GO - Biological processi
- chromatin remodeling Source: InterPro
- DNA repair Source: InterPro
Keywordsi
Molecular function | HelicaseARBA annotation, Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Chromodomain-helicase-DNA-binding protein 1-likeImported |
Gene namesi | Name:CHD1LImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1916, CHD1L |
VEuPathDBi | HostDB:ENSG00000131778 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000131778, Expressed in corpus callosum and 239 other tissues |
ExpressionAtlasi | A0A0A0MSH9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 151 | Helicase ATP-bindingInterPro annotationAdd BLAST | 151 | |
Domaini | 279 – 441 | Helicase C-terminalInterPro annotationAdd BLAST | 163 | |
Domaini | 632 – 825 | MacroInterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 556 – 582 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 615 – 639 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 559 – 582 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 619 – 636 | Acidic residuesSequence analysisAdd BLAST | 18 |
Phylogenomic databases
GeneTreei | ENSGT00940000159402 |
Family and domain databases
Gene3Di | 3.40.220.10, 1 hit 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031053, ALC1 IPR002464, DNA/RNA_helicase_DEAH_CS IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR002589, Macro_dom IPR043472, Macro_dom-like IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
PANTHERi | PTHR47157, PTHR47157, 1 hit |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51154, MACRO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MSH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLGKTCQTI ALFIYLAGRL NDEGPFLILC PLSVLSNWKE EMQRFAPGLS
60 70 80 90 100
CVTYAGDKEE RACLQQDLKQ ESRFHVLLTT YEICLKDASF LKSFPWSVLV
110 120 130 140 150
VDEAHRLKNQ SSLLHKTLSE FSVVFSLLLT GTPIQNSLQE LYSLLSFVEP
160 170 180 190 200
DLFSKEEVGD FIQRYQDIEK ESESASELHK LLQPFLLRRV KAEVATELPK
210 220 230 240 250
KTEVVIYHGM SALQKKYYKA ILMKDLDAFE NETAKKVKLQ NILSQLRKCV
260 270 280 290 300
DHPYLFDGVE PEPFEVGDHL TEASGKLHLL DKLLAFLYSG GHRVLLFSQM
310 320 330 340 350
TQMLDILQDY MDYRGYSYER VDGSVRGEER HLAIKNFGQQ PIFVFLLSTR
360 370 380 390 400
AGGVGMNLTA ADTVIFVDSD FNPQNDLQAA ARAHRIGQNK SVKVIRLIGR
410 420 430 440 450
DTVEEIVYRK AASKLQLTNM IIEGGHFTLG AQKPAADADL QLSEILKFGL
460 470 480 490 500
DKLLASEGST MDEIDLESIL GETKDGQWVS DALPAAEGGS RDQEEGKNHM
510 520 530 540 550
YLFEGKDYSK EPSKEDRKSF EQLVNLQKTL LEKASQEGRS LRNKGSVLIP
560 570 580 590 600
GLVEGSTKRK RVLSPEELED RQKKRQEAAA KRRRLIEEKK RQKEEAEHKK
610 620 630 640 650
KMAWWESNNY QSFCLPSEES EPEDLENGEE SSAELDYQDP DATSLKYVSG
660 670 680 690 700
DVTHPQAGAE DALIVHCVDD SGHWGRGGLF TALEKRSAEP RKIYELAGKM
710 720 730 740 750
KDLSLGGVLL FPVDDKESRN KGQDLLALIV AQHRDRSNVL SGIKMAALEE
760 770 780 790 800
GLKKIFLAAK KKKASVHLPR IGHATKGFNW YGTERLIRKH LAARGIPTYI
810 820
YYFPRSKSAV LHSQSSSSSS RQLVP
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86WJ1 | CHD1L_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L ALC1 | 897 | Annotation score: | ||
A0A0A0MRH8 | A0A0A0MRH8_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 745 | Annotation score: | ||
A0A494C1P7 | A0A494C1P7_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 792 | Annotation score: | ||
A0A494C1F7 | A0A494C1F7_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 880 | Annotation score: | ||
A0A494C179 | A0A494C179_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 516 | Annotation score: | ||
A0A087WTM4 | A0A087WTM4_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 377 | Annotation score: | ||
A0A1W2PP16 | A0A1W2PP16_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 219 | Annotation score: | ||
A0A494C1H0 | A0A494C1H0_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 192 | Annotation score: | ||
A0A494C0F0 | A0A494C0F0_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 293 | Annotation score: | ||
A0A494C111 | A0A494C111_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 204 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC242426 Genomic DNA No translation available. |
RefSeqi | NP_001335380.1, NM_001348451.1 NP_001335381.1, NM_001348452.1 |
Genome annotation databases
Ensembli | ENST00000431239; ENSP00000389031; ENSG00000131778 |
GeneIDi | 9557 |
UCSCi | uc031pok.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC242426 Genomic DNA No translation available. |
RefSeqi | NP_001335380.1, NM_001348451.1 NP_001335381.1, NM_001348452.1 |
3D structure databases
SMRi | A0A0A0MSH9 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A0A0MSH9 |
Protocols and materials databases
Antibodypediai | 20241, 197 antibodies from 30 providers |
DNASUi | 9557 |
Genome annotation databases
Ensembli | ENST00000431239; ENSP00000389031; ENSG00000131778 |
GeneIDi | 9557 |
UCSCi | uc031pok.1, human |
Organism-specific databases
CTDi | 9557 |
HGNCi | HGNC:1916, CHD1L |
OpenTargetsi | ENSG00000131778 |
VEuPathDBi | HostDB:ENSG00000131778 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159402 |
Miscellaneous databases
BioGRID-ORCSi | 9557, 6 hits in 1053 CRISPR screens |
ChiTaRSi | CHD1L, human |
GenomeRNAii | 9557 |
Gene expression databases
Bgeei | ENSG00000131778, Expressed in corpus callosum and 239 other tissues |
ExpressionAtlasi | A0A0A0MSH9, baseline and differential |
Family and domain databases
Gene3Di | 3.40.220.10, 1 hit 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031053, ALC1 IPR002464, DNA/RNA_helicase_DEAH_CS IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR002589, Macro_dom IPR043472, Macro_dom-like IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
PANTHERi | PTHR47157, PTHR47157, 1 hit |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51154, MACRO, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MSH9_HUMAN | |
Accessioni | A0A0A0MSH9Primary (citable) accession number: A0A0A0MSH9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | June 5, 2019 | |
Last modified: | January 19, 2022 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |