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Entry version 41 (11 Dec 2019)
Sequence version 1 (07 Jan 2015)
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Protein
Submitted name:

Laminin subunit alpha-3

Gene

LAMA3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Laminin subunit alpha-3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000053747.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6483 LAMA3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000053747

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Sequence analysisAdd BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500196725837 – 3277Sequence analysisAdd BLAST3241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi321 ↔ 330PROSITE-ProRule annotation
Disulfide bondi393 ↔ 402PROSITE-ProRule annotation
Disulfide bondi445 ↔ 454PROSITE-ProRule annotation
Disulfide bondi491 ↔ 503PROSITE-ProRule annotation
Disulfide bondi511 ↔ 520PROSITE-ProRule annotation
Disulfide bondi536 ↔ 548PROSITE-ProRule annotation
Disulfide bondi538 ↔ 555PROSITE-ProRule annotation
Disulfide bondi557 ↔ 566PROSITE-ProRule annotation
Disulfide bondi601 ↔ 610PROSITE-ProRule annotation
Disulfide bondi654 ↔ 663PROSITE-ProRule annotation
Disulfide bondi684 ↔ 696PROSITE-ProRule annotation
Disulfide bondi686 ↔ 703PROSITE-ProRule annotation
Disulfide bondi705 ↔ 714PROSITE-ProRule annotation
Disulfide bondi1266 ↔ 1278PROSITE-ProRule annotation
Disulfide bondi1268 ↔ 1285PROSITE-ProRule annotation
Disulfide bondi1287 ↔ 1296PROSITE-ProRule annotation
Disulfide bondi1328 ↔ 1337PROSITE-ProRule annotation
Disulfide bondi1380 ↔ 1389PROSITE-ProRule annotation
Disulfide bondi1405 ↔ 1417PROSITE-ProRule annotation
Disulfide bondi1407 ↔ 1424PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1435PROSITE-ProRule annotation
Disulfide bondi1706 ↔ 1715PROSITE-ProRule annotation
Disulfide bondi1734 ↔ 1746PROSITE-ProRule annotation
Disulfide bondi1757 ↔ 1766PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A0A0MSA0

PeptideAtlas

More...
PeptideAtlasi
A0A0A0MSA0

PRoteomics IDEntifications database

More...
PRIDEi
A0A0A0MSA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000053747 Expressed in 173 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A0MSA0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 298Laminin N-terminalInterPro annotationAdd BLAST256
Domaini299 – 355Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini356 – 425Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini426 – 469Laminin EGF-likeInterPro annotationAdd BLAST44
Domaini491 – 535Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini536 – 588Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini590 – 630Laminin EGF-likeInterPro annotationAdd BLAST41
Domaini631 – 683Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini684 – 728Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini1266 – 1311Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1312 – 1355Laminin EGF-likeInterPro annotationAdd BLAST44
Domaini1356 – 1404Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini1405 – 1455Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1476 – 1653Laminin IV type AInterPro annotationAdd BLAST178
Domaini1687 – 1733Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1734 – 1786Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini2334 – 2535LAM_G_DOMAINInterPro annotationAdd BLAST202
Domaini2542 – 2704LAM_G_DOMAINInterPro annotationAdd BLAST163
Domaini2711 – 2871LAM_G_DOMAINInterPro annotationAdd BLAST161
Domaini2930 – 3094LAM_G_DOMAINInterPro annotationAdd BLAST165
Domaini3101 – 3274LAM_G_DOMAINInterPro annotationAdd BLAST174

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1853 – 1936Sequence analysisAdd BLAST84
Coiled coili1965 – 2006Sequence analysisAdd BLAST42
Coiled coili2042 – 2076Sequence analysisAdd BLAST35
Coiled coili2079 – 2113Sequence analysisAdd BLAST35
Coiled coili2269 – 2289Sequence analysisAdd BLAST21
Coiled coili2307 – 2327Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155638

Database of Orthologous Groups

More...
OrthoDBi
2342at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 12 hits
PF02210 Laminin_G_2, 5 hits
PF06008 Laminin_I, 2 hits
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 14 hits
SM00281 LamB, 1 hit
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 14 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MSA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAARPRGR ALGPVLPPTP LLLLVLRVLP ACGATARDPG AAAGLSLHPT
60 70 80 90 100
YFNLAEAARI WATATCGERG PGEGRPQPEL YCKLVGGPTA PGSGHTIQGQ
110 120 130 140 150
FCDYCNSEDP RKAHPVTNAI DGSERWWQSP PLSSGTQYNR VNLTLDLGQL
160 170 180 190 200
FHVAYILIKF ANSPRPDLWV LERSVDFGST YSPWQYFAHS KVDCLKEFGR
210 220 230 240 250
EANMAVTRDD DVLCVTEYSR IVPLENGEVV VSLINGRPGA KNFTFSHTLR
260 270 280 290 300
EFTKATNIRL RFLRTNTLLG HLISKAQRDP TVTRRYYYSI KDISIGGQCV
310 320 330 340 350
CNGHAEVCNI NNPEKLFRCE CQHHTCGETC DRCCTGYNQR RWRPAAWEQS
360 370 380 390 400
HECEACNCHG HASNCYYDPD VERQQASLNT QGIYAGGGVC INCQHNTAGV
410 420 430 440 450
NCEQCAKGYY RPYGVPVDAP DGCIPCSCDP EHADGCEQGS GRCHCKPNFH
460 470 480 490 500
GDNCEKCAIG YYNFPFCLRI PIFPVSTPSS EDPVAGDIKG CDCNLEGVLP
510 520 530 540 550
EICDAHGRCL CRPGVEGPRC DTCRSGFYSF PICQACWCSA LGSYQMPCSS
560 570 580 590 600
VTGQCECRPG VTGQRCDRCL SGAYDFPHCQ GSSSACDPAG TINSNLGYCQ
610 620 630 640 650
CKLHVEGPTC SRCKLLYWNL DKENPSGCSE CKCHKAGTVS GTGECRQGDG
660 670 680 690 700
DCHCKSHVGG DSCDTCEDGY FALEKSNYFG CQGCQCDIGG ALSSMCSGPS
710 720 730 740 750
GVCQCREHVV GKVCQRPENN YYFPDLHHMK YEIEDGSTPN GRDLRFGFDP
760 770 780 790 800
LAFPEFSWRG YAQMTSVQND VRITLNVGKS SGSLFRVILR YVNPGTEAVS
810 820 830 840 850
GHITIYPSWG AAQSKEIIFL PSKEPAFVTV PGNGFADPFS ITPGIWVACI
860 870 880 890 900
KAEGVLLDYL VLLPRDYYEA SVLQLPVTEP CAYAGPPQEN CLLYQHLPVT
910 920 930 940 950
RFPCTLACEA RHFLLDGEPR PVAVRQPTPA HPVMVDLSGR EVELHLRLRI
960 970 980 990 1000
PQVGHYVVVV EYSTEAAQLF VVDVNVKSSG SVLAGQVNIY SCNYSVLCRS
1010 1020 1030 1040 1050
AVIDHMSRIA MYELLADADI QLKGHMARFL LHQVCIIPIE EFSAEYVRPQ
1060 1070 1080 1090 1100
VHCIASYGRF VNQSATCVSL AHETPPTALI LDVLSGRPFP HLPQQSSPSV
1110 1120 1130 1140 1150
DVLPGVTLKA PQNQVTLRGR VPHLGRYVFV IHFYQAAHPT FPAQVSVDGG
1160 1170 1180 1190 1200
WPRAGSFHAS FCPHVLGCRD QVIAEGQIEF DISEPEVAAT VKVPEGKSLV
1210 1220 1230 1240 1250
LVRVLVVPAE NYDYQILHKK SMDKSLEFIT NCGKNSFYLD PQTASRFCKN
1260 1270 1280 1290 1300
SARSLVAFYH KGALPCECHP TGATGPHCSP EGGQCPCQPN VIGRQCTRCA
1310 1320 1330 1340 1350
TGHYGFPRCK PCSCGRRLCE EMTGQCRCPP RTVRPQCEVC ETHSFSFHPM
1360 1370 1380 1390 1400
AGCEGCNCSR RGTIEAAMPE CDRDSGQCRC KPRITGRQCD RCASGFYRFP
1410 1420 1430 1440 1450
ECVPCNCNRD GTEPGVCDPG TGACLCKENV EGTECNVCRE GSFHLDPANL
1460 1470 1480 1490 1500
KGCTSCFCFG VNNQCHSSHK RRTKFVDMLG WHLETADRVD IPVSFNPGSN
1510 1520 1530 1540 1550
SMVADLQELP ATIHSASWVA PTSYLGDKVS SYGGYLTYQA KSFGLPGDMV
1560 1570 1580 1590 1600
LLEKKPDVQL TGQHMSIIYE ETNTPRPDRL HHGRVHVVEG NFRHASSRAP
1610 1620 1630 1640 1650
VSREELMTVL SRLADVRIQG LYFTETQRLT LSEVGLEEAS DTGSGRIALA
1660 1670 1680 1690 1700
VEICACPPAY AGDSCQGCSP GYYRDHKGLY TGRCVPCNCN GHSNQCQDGS
1710 1720 1730 1740 1750
GICVNCQHNT AGEHCERCQE GYYGNAVHGS CRACPCPHTN SFATGCVVNG
1760 1770 1780 1790 1800
GDVRCSCKAG YTGTQCERCA PGYFGNPQKF GGSCQPCSCN SNGQLGSCHP
1810 1820 1830 1840 1850
LTGDCINQEP KDSSPAEECD DCDSCVMTLL NDLATMGEQL RLVKSQLQGL
1860 1870 1880 1890 1900
SASAGLLEQM RHMETQAKDL RNQLLNYRSA ISNHGSKIEG LERELTDLNQ
1910 1920 1930 1940 1950
EFETLQEKAQ VNSRKAQTLN NNVNRATQSA KELDVKIKNV IRNVHMLNRI
1960 1970 1980 1990 2000
RTWQKTHQGE NNGLANSIRD SLNEYEAKLS DLRARLQEAA AQAKQANGLN
2010 2020 2030 2040 2050
QENERALGAI QRQVKEINSL QSDFTKYLTT ADSSLLQTNI ALQLMEKSQK
2060 2070 2080 2090 2100
EYEKLAASLN EARQELSDKV RELSRSAGKT SLVEEAEKHA RSLQELAKQL
2110 2120 2130 2140 2150
EEIKRNASGD ELVRCAVDAA TAYENILNAI KAAEDAANRA ASASESALQT
2160 2170 2180 2190 2200
VIKEDLPRKA KTLSSNSDKL LNEAKMTQKK LKQEVSPALN NLQQTLNIVT
2210 2220 2230 2240 2250
VQKEVIDTNL TTLRDGLHGI QRGDIDAMIS SAKSMVRKAN DITDEVLDGL
2260 2270 2280 2290 2300
NPIQTDVERI KDTYGRTQNE DFKKALTDAD NSVNKLTNKL PDLWRKIESI
2310 2320 2330 2340 2350
NQQLLPLGNI SDNMDRIREL IQQARDAASK VAVPMRFNGK SGVEVRLPND
2360 2370 2380 2390 2400
LEDLKGYTSL SLFLQRPNSR ENGGTENMFV MYLGNKDASR DYIGMAVVDG
2410 2420 2430 2440 2450
QLTCVYNLGD REAELQVDQI LTKSETKEAV MDRVKFQRIY QFARLNYTKG
2460 2470 2480 2490 2500
ATSSKPETPG VYDMDGRNSN TLLNLDPENV VFYVGGYPPD FKLPSRLSFP
2510 2520 2530 2540 2550
PYKGCIELDD LNENVLSLYN FKKTFNLNTT EVEPCRRRKE ESDKNYFEGT
2560 2570 2580 2590 2600
GYARVPTQPH APIPTFGQTI QTTVDRGLLF FAENGDRFIS LNIEDGKLMV
2610 2620 2630 2640 2650
RYKLNSELPK ERGVGDAINN GRDHSIQIKI GKLQKRMWIN VDVQNTIIDG
2660 2670 2680 2690 2700
EVFDFSTYYL GGIPIAIRER FNISTPAFRG CMKNLKKTSG VVRLNDTVGV
2710 2720 2730 2740 2750
TKKCSEDWKL VRSASFSRGG QLSFTDLGLP PTDHLQASFG FQTFQPSGIL
2760 2770 2780 2790 2800
LDHQTWTRNL QVTLEDGYIE LSTSDSGGPI FKSPQTYMDG LLHYVSVISD
2810 2820 2830 2840 2850
NSGLRLLIDD QLLRNSKRLK HISSSRQSLR LGGSNFEGCI SNVFVQRLSL
2860 2870 2880 2890 2900
SPEVLDLTSN SLKRDVSLGG CSLNKPPFLM LLKGSTRFNK TKTFRINQLL
2910 2920 2930 2940 2950
QDTPVASPRS VKVWQDACSP LPKTQANHGA LQFGDIPTSH LLFKLPQELL
2960 2970 2980 2990 3000
KPRSQFAVDM QTTSSRGLVF HTGTKNSFMA LYLSKGRLVF ALGTDGKKLR
3010 3020 3030 3040 3050
IKSKEKCNDG KWHTVVFGHD GEKGRLVVDG LRAREGSLPG NSTISIRAPV
3060 3070 3080 3090 3100
YLGSPPSGKP KSLPTNSFVG CLKNFQLDSK PLYTPSSSFG VSSCLGGPLE
3110 3120 3130 3140 3150
KGIYFSEEGG HVVLAHSVLL GPEFKLVFSI RPRSLTGILI HIGSQPGKHL
3160 3170 3180 3190 3200
CVYLEAGKVT ASMDSGAGGT STSVTPKQSL CDGQWHSVAV TIKQHILHLE
3210 3220 3230 3240 3250
LDTDSSYTAG QIPFPPASTQ EPLHLGGAPA NLTTLRIPVW KSFFGCLRNI
3260 3270
HVNHIPVPVT EALEVQGPVS LNGCPDQ
Length:3,277
Mass (Da):360,182
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCACFFE9D7021C943
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q16787LAMA3_HUMAN
Laminin subunit alpha-3
LAMA3 LAMNA
3,333Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTS5A0A0A0MTS5_HUMAN
HCG1811249, isoform CRA_f
LAMA3 hCG_1811249
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYF2A0A0A6YYF2_HUMAN
HCG1811249, isoform CRA_e
LAMA3 hCG_1811249
1,724Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIP4K7EIP4_HUMAN
Laminin subunit alpha-3
LAMA3
1,147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITG1A0A3B3ITG1_HUMAN
Laminin subunit alpha-3
LAMA3
2,198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B783A0A075B783_HUMAN
Laminin subunit alpha-3
LAMA3
576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERM0K7ERM0_HUMAN
Laminin subunit alpha-3
LAMA3
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPP3K7EPP3_HUMAN
Laminin subunit alpha-3
LAMA3
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMU9K7EMU9_HUMAN
Laminin subunit alpha-3
LAMA3
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ42K7EQ42_HUMAN
Laminin subunit alpha-3
LAMA3
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010754 Genomic DNA No translation available.
AC067796 Genomic DNA No translation available.
AC090366 Genomic DNA No translation available.
KF456351 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001121189.2, NM_001127717.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399516; ENSP00000382432; ENSG00000053747

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3909

UCSC genome browser

More...
UCSCi
uc002kur.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010754 Genomic DNA No translation available.
AC067796 Genomic DNA No translation available.
AC090366 Genomic DNA No translation available.
KF456351 Genomic DNA No translation available.
RefSeqiNP_001121189.2, NM_001127717.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiA0A0A0MSA0
PeptideAtlasiA0A0A0MSA0
PRIDEiA0A0A0MSA0

Genome annotation databases

EnsembliENST00000399516; ENSP00000382432; ENSG00000053747
GeneIDi3909
UCSCiuc002kur.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3909
EuPathDBiHostDB:ENSG00000053747.15
HGNCiHGNC:6483 LAMA3
OpenTargetsiENSG00000053747

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000155638
OrthoDBi2342at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMA3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3909

Gene expression databases

BgeeiENSG00000053747 Expressed in 173 organ(s), highest expression level in ectocervix
ExpressionAtlasiA0A0A0MSA0 baseline and differential

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 12 hits
PF02210 Laminin_G_2, 5 hits
PF06008 Laminin_I, 2 hits
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 14 hits
SM00281 LamB, 1 hit
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 14 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A0MSA0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A0MSA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: December 11, 2019
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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