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Protein
Submitted name:

Collagen and calcium-binding EGF domain-containing protein 1

Gene

CCBE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen and calcium-binding EGF domain-containing protein 1Imported
Gene namesi
Name:CCBE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000183287.13
HGNCiHGNC:29426 CCBE1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183287

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiA0A0A0MS88

Expressioni

Gene expression databases

BgeeiENSG00000183287 Expressed in 147 organ(s), highest expression level in neocortex
ExpressionAtlasiA0A0A0MS88 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MS88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 105EGF-likeInterPro annotationAdd BLAST42

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IRWI Eukaryota
ENOG4111SKA LUCA
GeneTreeiENSGT00390000014907

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF07645 EGF_CA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

A0A0A0MS88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RKKCCKGYKF VLGQCIPEDY DVCAEAPCEQ QCTDNFGRVL CTCYPGYRYD
60 70 80 90 100
RERHRKREKP YCLDIDECAS SNGTLCAHIC INTLGSYRCE CREGYIREDD
110 120 130 140 150
GKTCTRGDKY PNDTGHEKSE NMVKAGTCCA TCKEFYQMKQ TVLQLKQKIA
160 170 180 190 200
LLPNNAADLG KYITGDKVLA SNTYLPGPPG LPGGQGPPGS PGPKGSPGFP
210 220 230 240 250
GMPGPPGQPG PRGSMGPMGP SPDLSHIKQG RRGPVGPPGA PGRDGSKGER
260 270 280 290 300
GAPGPRGSPG PPGSFDFLLL MLADIRNDIT ELQEKVFGHR THSSAEEFPL
310 320 330
PQEFPSYPEA MDLGSGDDHP RRTETRDLRA PRDFYP
Length:336
Mass (Da):36,544
Last modified:January 7, 2015 - v1
Checksum:i0CF642B07565CBB7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6UXH8CCBE1_HUMAN
Collagen and calcium-binding EGF do...
CCBE1 KIAA1983, UNQ1921/PRO4395
406Annotation score:
K7EQ81K7EQ81_HUMAN
Collagen and calcium-binding EGF do...
CCBE1
46Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010776 Genomic DNA No translation available.
AC016229 Genomic DNA No translation available.
AC090213 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000398179; ENSP00000381241; ENSG00000183287
UCSCiuc060prl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010776 Genomic DNA No translation available.
AC016229 Genomic DNA No translation available.
AC090213 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0A0MS88
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0A0MS88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398179; ENSP00000381241; ENSG00000183287
UCSCiuc060prl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000183287.13
HGNCiHGNC:29426 CCBE1
OpenTargetsiENSG00000183287
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRWI Eukaryota
ENOG4111SKA LUCA
GeneTreeiENSGT00390000014907

Miscellaneous databases

ChiTaRSiCCBE1 human

Gene expression databases

BgeeiENSG00000183287 Expressed in 147 organ(s), highest expression level in neocortex
ExpressionAtlasiA0A0A0MS88 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF07645 EGF_CA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0MS88_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MS88
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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