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Entry version 46 (02 Dec 2020)
Sequence version 1 (07 Jan 2015)
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Protein
Submitted name:

Zinc finger protein 99

Gene

ZNF99

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 99Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF99Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000213973.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13175, ZNF99

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000213973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0A0MS76

PeptideAtlas

More...
PeptideAtlasi
A0A0A0MS76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213973, Expressed in female gonad and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A0MS76, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 96KRABInterPro annotationAdd BLAST72
Domaini166 – 193C2H2-typeInterPro annotationAdd BLAST28
Domaini194 – 221C2H2-typeInterPro annotationAdd BLAST28
Domaini222 – 249C2H2-typeInterPro annotationAdd BLAST28
Domaini250 – 277C2H2-typeInterPro annotationAdd BLAST28
Domaini278 – 305C2H2-typeInterPro annotationAdd BLAST28
Domaini306 – 333C2H2-typeInterPro annotationAdd BLAST28
Domaini334 – 361C2H2-typeInterPro annotationAdd BLAST28
Domaini362 – 389C2H2-typeInterPro annotationAdd BLAST28
Domaini390 – 417C2H2-typeInterPro annotationAdd BLAST28
Domaini418 – 445C2H2-typeInterPro annotationAdd BLAST28
Domaini446 – 473C2H2-typeInterPro annotationAdd BLAST28
Domaini474 – 501C2H2-typeInterPro annotationAdd BLAST28
Domaini502 – 529C2H2-typeInterPro annotationAdd BLAST28
Domaini530 – 557C2H2-typeInterPro annotationAdd BLAST28
Domaini558 – 585C2H2-typeInterPro annotationAdd BLAST28
Domaini586 – 613C2H2-typeInterPro annotationAdd BLAST28
Domaini614 – 641C2H2-typeInterPro annotationAdd BLAST28
Domaini642 – 669C2H2-typeInterPro annotationAdd BLAST28
Domaini670 – 697C2H2-typeInterPro annotationAdd BLAST28
Domaini698 – 725C2H2-typeInterPro annotationAdd BLAST28
Domaini746 – 773C2H2-typeInterPro annotationAdd BLAST28
Domaini774 – 801C2H2-typeInterPro annotationAdd BLAST28
Domaini802 – 829C2H2-typeInterPro annotationAdd BLAST28
Domaini830 – 857C2H2-typeInterPro annotationAdd BLAST28
Domaini858 – 887C2H2-typeInterPro annotationAdd BLAST30
Domaini888 – 915C2H2-typeInterPro annotationAdd BLAST28
Domaini916 – 943C2H2-typeInterPro annotationAdd BLAST28
Domaini944 – 971C2H2-typeInterPro annotationAdd BLAST28
Domaini982 – 1009C2H2-typeInterPro annotationAdd BLAST28
Domaini1010 – 1037C2H2-typeInterPro annotationAdd BLAST28

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163381

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_1_1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A0A0MS76

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 27 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 17 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 26 hits
PS50157, ZINC_FINGER_C2H2_2, 30 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0A0MS76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFWSEKCTR LILYDLKIAL KNGSLTFWDV TIEFALEEWQ CLDMAQQNLY
60 70 80 90 100
RNVMLENYRN LVFLGIAVSK LDLITCLKQG KEPWNMKRHE MVTKPPVISS
110 120 130 140 150
HFTQDFWPDQ SIKDSFQEII LRTYARCGHK NLRLRKDCES VNEGKMHEEA
160 170 180 190 200
YNKLNQCWTT TQGKIFQCNK YVKVFHKYSN SNRYKIIHTG KKPYKCEECG
210 220 230 240 250
KAFKQSSHLT RHKAIHTGEK PYKCEECGKA FNHFSALRKH QIIHTGKKPY
260 270 280 290 300
KCEECGKAFS QSSTLRKHEI IHTEEKPYKY EECGKAFSNL SALRKHEIIH
310 320 330 340 350
TGQKPYKCEE CGKAFKWSSK LTVHKVIHTA EKPCKCEECG KAFKRFSALR
360 370 380 390 400
KHKIIHTGKQ PYKCEECSKA FSNFSALRKH EIIHTGEKPY KCEECGKAFK
410 420 430 440 450
WSSKLTVHKV IHMEEKPCKC EECGKAFKHF SALRKHKIIH TGKKPYKCEE
460 470 480 490 500
CGKAFNNSST LMKHKIIHTG KKPYKCEECG KAFKQSSHLT RHKAIHTGEK
510 520 530 540 550
PYKCEECGKA FNHFSALRKH QIIHTGKKPY KCEECGKAFS QSSTLRKHEI
560 570 580 590 600
IHTGEKPYKC EECGKAFKWS SHLTRHKVIH TEEKPYKCEE CGKAFNHFSA
610 620 630 640 650
LRKHKIIHTG KKPYKCEECG KAFSQSSTLR KHEIIHTGEK PYKCEECGKA
660 670 680 690 700
FKWSSKLTVH KVIHTAEKPC KCEECGKAFK HFSALRKHKI IHTGKKPYKC
710 720 730 740 750
EECGKAFNNS STLRKHEIIH TGEKSYKCEE CALRKHEIIH TGKKPYKCEE
760 770 780 790 800
CGKAFNNSST LRKHKIIYTG KKPYKCEECG KAFKQSSHLT RHKAVHTGEK
810 820 830 840 850
PYKCGECGKA FNNSSTLKKH KLIHTREKSY KCEECGKAFS NFSALRKHKI
860 870 880 890 900
IHTGEKPYKC EECECGKAFN NSSTLMKHKI IHTGEKPYKC EECGKGFNNF
910 920 930 940 950
STLMKHKIIH TGEKPYKCEE CGKAFKQSSH LTKHKSIHTG EKPYKCEERG
960 970 980 990 1000
KAFSHFSRLT KHRIIHTGKK PYKCEECGEK PYKCEECGKA FNQSSHLTQH
1010 1020 1030
KTIHTGGKTY KCEECGKAFN HLSALTKHKI IHTGEKP
Length:1,037
Mass (Da):120,152
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i143AAD452B078CD5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXY4ZNF99_HUMAN
Zinc finger protein 99
ZNF99 C19orf9
864Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008626 Genomic DNA No translation available.
AC024563 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397104; ENSP00000380293; ENSG00000213973

UCSC genome browser

More...
UCSCi
uc060wjg.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008626 Genomic DNA No translation available.
AC024563 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiA0A0A0MS76
PeptideAtlasiA0A0A0MS76

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56870, 56 antibodies

Genome annotation databases

EnsembliENST00000397104; ENSP00000380293; ENSG00000213973
UCSCiuc060wjg.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000213973.8
HGNCiHGNC:13175, ZNF99
OpenTargetsiENSG00000213973

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163381
HOGENOMiCLU_002678_17_1_1
PhylomeDBiA0A0A0MS76

Gene expression databases

BgeeiENSG00000213973, Expressed in female gonad and 21 other tissues
ExpressionAtlasiA0A0A0MS76, baseline and differential

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 27 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 30 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 17 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 26 hits
PS50157, ZINC_FINGER_C2H2_2, 30 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A0MS76_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A0MS76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: December 2, 2020
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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