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UniProtKB - A0A0A0MRH8 (A0A0A0MRH8_HUMAN)
Protein
Submitted name:
Chromodomain-helicase-DNA-binding protein 1-like
Gene
CHD1L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- DNA helicase activity Source: InterPro
GO - Biological processi
- chromatin remodeling Source: InterPro
- DNA repair Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Chromodomain-helicase-DNA-binding protein 1-likeImported |
Gene namesi | Name:CHD1LImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1916, CHD1L |
VEuPathDBi | HostDB:ENSG00000131778 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000131778, Expressed in corpus callosum and 239 other tissues |
ExpressionAtlasi | A0A0A0MRH8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 199 – 361 | Helicase C-terminalInterPro annotationAdd BLAST | 163 | |
Domaini | 552 – 745 | MacroInterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 476 – 502 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 535 – 559 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 479 – 502 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 539 – 556 | Acidic residuesSequence analysisAdd BLAST | 18 |
Phylogenomic databases
GeneTreei | ENSGT00940000159402 |
HOGENOMi | CLU_000315_17_9_1 |
Family and domain databases
Gene3Di | 3.40.220.10, 1 hit 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031053, ALC1 IPR001650, Helicase_C IPR002589, Macro_dom IPR043472, Macro_dom-like IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
PANTHERi | PTHR47157, PTHR47157, 2 hits |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS51194, HELICASE_CTER, 1 hit PS51154, MACRO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MRH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERAGATSRG GQAPGFLLRL HTEGRAEAAR VQEQDLRQWG LTVVFSLLLT
60 70 80 90 100
GTPIQNSLQE LYSLLSFVEP DLFSKEEVGD FIQRYQDIEK ESESASELHK
110 120 130 140 150
LLQPFLLRRV KAEVATELPK KTEVVIYHGM SALQKKYYKA ILMKDLDAFE
160 170 180 190 200
NETAKKVKLQ NILSQLRKCV DHPYLFDGVE PEPFEVGDHL TEASGKLHLL
210 220 230 240 250
DKLLAFLYSG GHRVLLFSQM TQMLDILQDY MDYRGYSYER VDGSVRGEER
260 270 280 290 300
HLAIKNFGQQ PIFVFLLSTR AGGVGMNLTA ADTVIFVDSD FNPQNDLQAA
310 320 330 340 350
ARAHRIGQNK SVKVIRLIGR DTVEEIVYRK AASKLQLTNM IIEGGHFTLG
360 370 380 390 400
AQKPAADADL QLSEILKFGL DKLLASEGST MDEIDLESIL GETKDGQWVS
410 420 430 440 450
DALPAAEGGS RDQEEGKNHM YLFEGKDYSK EPSKEDRKSF EQLVNLQKTL
460 470 480 490 500
LEKASQEGRS LRNKGSVLIP GLVEGSTKRK RVLSPEELED RQKKRQEAAA
510 520 530 540 550
KRRRLIEEKK RQKEEAEHKK KMAWWESNNY QSFCLPSEES EPEDLENGEE
560 570 580 590 600
SSAELDYQDP DATSLKYVSG DVTHPQAGAE DALIVHCVDD SGHWGRGGLF
610 620 630 640 650
TALEKRSAEP RKIYELAGKM KDLSLGGVLL FPVDDKESRN KGQDLLALIV
660 670 680 690 700
AQHRDRSNVL SGIKMAALEE GLKKIFLAAK KKKASVHLPR IGHATKGFNW
710 720 730 740
YGTERLIRKH LAARGIPTYI YYFPRSKSAV LHSQSSSSSS RQLVP
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86WJ1 | CHD1L_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L ALC1 | 897 | Annotation score: | ||
A0A0A0MSH9 | A0A0A0MSH9_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 825 | Annotation score: | ||
A0A494C1P7 | A0A494C1P7_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 792 | Annotation score: | ||
A0A494C1F7 | A0A494C1F7_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 880 | Annotation score: | ||
A0A494C179 | A0A494C179_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 516 | Annotation score: | ||
A0A087WTM4 | A0A087WTM4_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 377 | Annotation score: | ||
A0A1W2PP16 | A0A1W2PP16_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 219 | Annotation score: | ||
A0A494C1H0 | A0A494C1H0_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 192 | Annotation score: | ||
A0A494C0F0 | A0A494C0F0_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 293 | Annotation score: | ||
A0A494C111 | A0A494C111_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1L | 204 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC242426 Genomic DNA No translation available. |
RefSeqi | NP_001335383.1, NM_001348454.1 |
Genome annotation databases
Ensembli | ENST00000361293; ENSP00000355100; ENSG00000131778 |
GeneIDi | 9557 |
UCSCi | uc010ozp.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC242426 Genomic DNA No translation available. |
RefSeqi | NP_001335383.1, NM_001348454.1 |
3D structure databases
SMRi | A0A0A0MRH8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A0A0MRH8, 1 interactor |
Proteomic databases
PeptideAtlasi | A0A0A0MRH8 |
Protocols and materials databases
Antibodypediai | 20241, 197 antibodies from 30 providers |
DNASUi | 9557 |
Genome annotation databases
Ensembli | ENST00000361293; ENSP00000355100; ENSG00000131778 |
GeneIDi | 9557 |
UCSCi | uc010ozp.3, human |
Organism-specific databases
CTDi | 9557 |
HGNCi | HGNC:1916, CHD1L |
OpenTargetsi | ENSG00000131778 |
VEuPathDBi | HostDB:ENSG00000131778 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159402 |
HOGENOMi | CLU_000315_17_9_1 |
Miscellaneous databases
BioGRID-ORCSi | 9557, 6 hits in 1053 CRISPR screens |
ChiTaRSi | CHD1L, human |
GenomeRNAii | 9557 |
Gene expression databases
Bgeei | ENSG00000131778, Expressed in corpus callosum and 239 other tissues |
ExpressionAtlasi | A0A0A0MRH8, baseline and differential |
Family and domain databases
Gene3Di | 3.40.220.10, 1 hit 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031053, ALC1 IPR001650, Helicase_C IPR002589, Macro_dom IPR043472, Macro_dom-like IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
PANTHERi | PTHR47157, PTHR47157, 2 hits |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS51194, HELICASE_CTER, 1 hit PS51154, MACRO, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MRH8_HUMAN | |
Accessioni | A0A0A0MRH8Primary (citable) accession number: A0A0A0MRH8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | July 3, 2019 | |
Last modified: | January 19, 2022 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |