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Entry version 39 (22 Apr 2020)
Sequence version 1 (07 Jan 2015)
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Protein
Submitted name:

Protocadherin-23

Gene

DCHS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protocadherin-23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCHS2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197410.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23111 DCHS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197410

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197410 Expressed in secondary oocyte and 84 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A0MRC0 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0A0MRC0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 165CAInterPro annotationAdd BLAST80
Domaini189 – 294CAInterPro annotationAdd BLAST106
Domaini318 – 411CAInterPro annotationAdd BLAST94
Domaini439 – 537CAInterPro annotationAdd BLAST99
Domaini561 – 661CAInterPro annotationAdd BLAST101
Domaini685 – 769CAInterPro annotationAdd BLAST85
Domaini793 – 866CAInterPro annotationAdd BLAST74
Domaini895 – 977CAInterPro annotationAdd BLAST83
Domaini1001 – 1081CAInterPro annotationAdd BLAST81
Domaini1105 – 1189CAInterPro annotationAdd BLAST85
Domaini1213 – 1292CAInterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni1346 – 1369DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1353 – 1369PolarSequence analysisAdd BLAST17

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162999

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001273_1_0_1

KEGG Orthology (KO)

More...
KOi
K16507

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MRC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPCGRKMGE GRQQRRAPVG KLLLLPGRRD TPHGRSGSSG ARTQRSLLWL
60 70 80 90 100
LVHVWLWAAS GSSAQLFNLT LSVDEGLPPD TLVGDIRAGL PAAQQQEGSG
110 120 130 140 150
FFLSEDSDDS PLLDDFHVHP DTGIIRTARR LDRERRDHYS FVAATLLGAV
160 170 180 190 200
VQVEIRVNDV NDHSPRFPLD SLQLDVSELS PPGTAFRLPV AHDPDAGLFS
210 220 230 240 250
TQGYTLVQPS DLPKDPAGPF FQLRYRTPGP LPSPLLPGSS SPLEPLDLVL
260 270 280 290 300
LRRLDREEAA AHRLQIEAWD GGRPRRTGLL SVELRVLDEN DNPPVFEQDE
310 320 330 340 350
YRAAVREDAQ PGAEVCRVRA TDRDLGPNGF VRYSVRARQV PGAGSGGGAL
360 370 380 390 400
GDAAYFAVEE LSGVVRVWRP LDREAQAWHQ LVVEARDGGA EPEVATVRVS
410 420 430 440 450
IAVLDVNDNR PAIHVLFLTE GGVARVSEGA RPGDYVARVS VSDADGDWEK
460 470 480 490 500
EDEATGELGV GLGDGSISLS LEGGEGDFAL LPGGPPGVFF LCVEGPLDRE
510 520 530 540 550
SRDLYELLLV ATDAGSPPLS TEETLLLRVA DLNDQPPLFS QQHYKASVSE
560 570 580 590 600
AAAPGTVVMW VSASDADEAG SDHAWLRYTV VQLSAPCNLG SLQSKMVHTA
610 620 630 640 650
ECGPSFAIDS ESGAISTIRT LDREVQEAVE LKVVAQDLGE PPLSATCLVS
660 670 680 690 700
ITVDDVNDNE PIFWRQVYNA TIAEHAPVGH CFLQVTASDA DSGLYGFIEY
710 720 730 740 750
SLYDGFLSYE APQAFRIDPH DGQICVSQDI DRERDPATYD LLVEAKDGGG
760 770 780 790 800
LSAQAFVRVD LEDVNDNHPV FNPSTYVTSI SDETQPGTEI INVLATDQDS
810 820 830 840 850
GIYGTVAYEL IPGNVSSLFT IDSTTGIIYL TLPLSHLEST TLSLMVSAQD
860 870 880 890 900
GGGLTAVINA DVTIHIFQTT LAPAEFERPK YTFLVYEDVP EDSPIGTVKA
910 920 930 940 950
REPLNSSEPI FYRISSGDLG GKFSIHPRLG TIRTRKPLDH ETQPVVVLTV
960 970 980 990 1000
QAQLGSAPAC SSTEVNITVM DVNDNHPAFL RTSDEIRISQ TTPPGTALYL
1010 1020 1030 1040 1050
ARAEDRDSGR NGLIRYSIAS PQPGVFAIDR ALGVLFLNGS LGAGEQRELT
1060 1070 1080 1090 1100
LTLRAEDQGV HPQAALLVLT VVIEKREHSP SWTFEHLVYQ VEVSESLSPM
1110 1120 1130 1140 1150
TQMLQTQAHP LGPQRAASPL RYSLEPSVDS AMFGIRPYTG WIYLRRQFDY
1160 1170 1180 1190 1200
ESTQTYNFRV FAWIPEDGFL QNVSTTVIVR VWDENDNSPT FLHDVLFLKV
1210 1220 1230 1240 1250
EESPVPQGVI GKITAIDMDS GKNGQLLYFL LSDGKFFKMN PNTGELINWV
1260 1270 1280 1290 1300
ALDREHRGHH EMTVLVTDRG SPPRNATMAV YVSVTDINDN RPFFPQCLPG
1310 1320 1330 1340 1350
KELHVKVLEG QPVNMLVTTV FAKDPDEGNN AEVTYSVSSA RPMPLKGKTA
1360
FGKQSCKKQT NKQTNKILT
Length:1,369
Mass (Da):149,304
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF67CCC40F454EC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6V1P9PCD23_HUMAN
Protocadherin-23
DCHS2 CDH27, CDHJ, PCDH23, PCDHJ
2,916Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNH0A0A096LNH0_HUMAN
Protocadherin-23
DCHS2
3,371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC079298 Genomic DNA No translation available.
AC110608 Genomic DNA No translation available.
AC110775 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001136024.1, NM_001142552.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339452; ENSP00000345062; ENSG00000197410
ENST00000639512; ENSP00000492852; ENSG00000284227

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54798

UCSC genome browser

More...
UCSCi
uc003inx.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079298 Genomic DNA No translation available.
AC110608 Genomic DNA No translation available.
AC110775 Genomic DNA No translation available.
RefSeqiNP_001136024.1, NM_001142552.1

3D structure databases

SMRiA0A0A0MRC0
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
74247 4 antibodies

Genome annotation databases

EnsembliENST00000339452; ENSP00000345062; ENSG00000197410
ENST00000639512; ENSP00000492852; ENSG00000284227
GeneIDi54798
KEGGihsa:54798
UCSCiuc003inx.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54798
EuPathDBiHostDB:ENSG00000197410.12
HGNCiHGNC:23111 DCHS2
OpenTargetsiENSG00000197410

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000162999
HOGENOMiCLU_001273_1_0_1
KOiK16507
OrthoDBi34489at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DCHS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54798

Gene expression databases

BgeeiENSG00000197410 Expressed in secondary oocyte and 84 other tissues
ExpressionAtlasiA0A0A0MRC0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 9 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 11 hits
SUPFAMiSSF49313 SSF49313, 12 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A0MRC0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A0MRC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: April 22, 2020
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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