UniProtKB - A0A0A0MR92 (A0A0A0MR92_HUMAN)
Protein
Submitted name:
CASP8 and FADD-like apoptosis regulator
Gene
CFLAR
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
GO - Biological processi
- regulation of apoptotic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: CASP8 and FADD-like apoptosis regulatorImported |
Gene namesi | Name:CFLARImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000003402.19 |
HGNCi | HGNC:1876, CFLAR |
Expressioni
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
ExpressionAtlasi | A0A0A0MR92, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 74 | DEDInterPro annotationAdd BLAST | 74 | |
Domaini | 149 – 244 | CASPASE_P20InterPro annotationAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the peptidase C14A family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00530000064199 |
HOGENOMi | CLU_036904_4_2_1 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 1 hit |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MR92-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEIGEDLDK SDVSSLIFLM KDYMGRGKIS KEKSFLDLVV ELEKLNLVAP
60 70 80 90 100
DQLDLLEKCL KNIHRIDLKT KIQKYKQSVQ GAGTSYRNVL QAAIQKSLKD
110 120 130 140 150
PSNNFREEPV KKSIQESEAF LPQSIPEERY KMKSKPLGIC LIIDCIGNET
160 170 180 190 200
ELLRDTFTSL GYEVQKFLHL SMHGISQILG QFACMPEHRD YDSFVCVLVS
210 220 230 240 250
RGGSQSVYGV DQTHSGLPLH HIRRMFMGDS CPYLAGKPKM FFIQNYVVSE
260 270 280 290 300
GQLEDSSLLE VDGPAMKNVE FKAQKRGLCT VHREADFFWS LCTADMSLLE
310 320
QSHSSPSLYL QCLSQKLRQE R
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15519 | CFLAR_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR CASH, CASP8AP1, CLARP, MRIT | 480 | Annotation score: | ||
E9PAP3 | E9PAP3_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 250 | Annotation score: | ||
F8WBH9 | F8WBH9_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 243 | Annotation score: | ||
C9J408 | C9J408_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 129 | Annotation score: | ||
C9J4Q0 | C9J4Q0_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 64 | Annotation score: | ||
C9JV51 | C9JV51_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 118 | Annotation score: | ||
M0QYM0 | M0QYM0_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 168 | Annotation score: | ||
M0R1A8 | M0R1A8_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 117 | Annotation score: | ||
M0QY57 | M0QY57_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 117 | Annotation score: | ||
C9JSU3 | C9JSU3_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 62 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007283 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000340870; ENSP00000339326; ENSG00000003402 |
UCSCi | uc061ril.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007283 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A0A0MR92 |
Protocols and materials databases
Antibodypediai | 19934, 924 antibodies |
Genome annotation databases
Ensembli | ENST00000340870; ENSP00000339326; ENSG00000003402 |
UCSCi | uc061ril.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000003402.19 |
HGNCi | HGNC:1876, CFLAR |
OpenTargetsi | ENSG00000003402 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000064199 |
HOGENOMi | CLU_036904_4_2_1 |
Miscellaneous databases
ChiTaRSi | CFLAR, human |
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
ExpressionAtlasi | A0A0A0MR92, baseline and differential |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 1 hit |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MR92_HUMAN | |
Accessioni | A0A0A0MR92Primary (citable) accession number: A0A0A0MR92 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | August 12, 2020 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |