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Protein
Submitted name:

Gamma-aminobutyric acid receptor subunit gamma-3

Gene

GABRG3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid receptor subunit gamma-3Imported
Gene namesi
Name:GABRG3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000182256.12
HGNCiHGNC:4088 GABRG3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei74 – 98HelicalSequence analysisAdd BLAST25
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Transmembranei268 – 287HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182256

PTM / Processingi

Proteomic databases

PRIDEiA0A0A0MR73

Expressioni

Gene expression databases

BgeeiENSG00000182256 Expressed in 66 organ(s), highest expression level in corpus callosum
ExpressionAtlasiA0A0A0MR73 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MR73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 74Neur_chan_LBDInterPro annotationAdd BLAST74
Domaini81 – 282Neur_chan_membInterPro annotationAdd BLAST202

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR005440 GABBAg3_rcpt
IPR005437 GABBAg_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01620 GABAARGAMMA
PR01623 GABAARGAMMA3
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

A0A0A0MR73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEHSCPLIF SSYGYPKEEM IYRWRKNSVE AADQKSWRLY QFDFMGLRNT
60 70 80 90 100
TEIVTTSAGD YVVMTIYFEL SRRMGYFTIQ TYIPCILTVV LSWVSFWIKK
110 120 130 140 150
DATPARTALG ITTVLTMTTL STIARKSLPR VSYVTAMDLF VTVCFLFVFA
160 170 180 190 200
ALMEYATLNY YSSCRKPTTT KKTTSLLHPD SSRWIPERIS LQAPSNYSLL
210 220 230 240 250
DMRPPPTAMI TLNNSVYWQE FEDTCVYECL DGKDCQSFFC CYEECKSGSW
260 270 280
RKGRIHIDIL ELDSYSRVFF PTSFLLFNLV YWVGYLYL
Length:288
Mass (Da):33,582
Last modified:January 7, 2015 - v1
Checksum:i636D6B7AF7698428
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99928GBRG3_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
467Annotation score:
H0YJP1H0YJP1_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
258Annotation score:
H7BZQ0H7BZQ0_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
169Annotation score:
H0YJ81H0YJ81_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
38Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127511 Genomic DNA No translation available.
AC135326 Genomic DNA No translation available.
AC136896 Genomic DNA No translation available.
AC144833 Genomic DNA No translation available.
AC145436 Genomic DNA No translation available.
EU606049 Genomic DNA No translation available.
KC877538 Genomic DNA No translation available.
KF511214 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000333743; ENSP00000331912; ENSG00000182256
UCSCiuc059gxz.1 human

Similar proteinsi

Entry informationi

Entry nameiA0A0A0MR73_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MR73
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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