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Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 10

Gene

ADAMTS10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 10Imported
Gene namesi
Name:ADAMTS10Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142303.13
HGNCiHGNC:13201 ADAMTS10

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501401596426 – 1103Sequence analysisAdd BLAST1078

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiA0A0A0MQW6
PRIDEiA0A0A0MQW6

Expressioni

Gene expression databases

BgeeiENSG00000142303 Expressed in 204 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiA0A0A0MQW6 baseline and differential

Structurei

3D structure databases

SMRiA0A0A0MQW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 457Peptidase M12BInterPro annotationAdd BLAST219
Domaini1065 – 1103PLACInterPro annotationAdd BLAST39

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
KOiK08625
OMAiLEACHGP
OrthoDBiEOG091G14M8

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 5 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MQW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN
60 70 80 90 100
GALLAFSPPP PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG
110 120 130 140 150
HVSVEYWTRE GLAWQRAARP HCLYAGHLQG QASSSHVAIS TCGGLHGLIV
160 170 180 190 200
ADEEEYLIEP LHGGPKGSRS PEESGPHVVY KRSSLRHPHL DTACGVRDEK
210 220 230 240 250
PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY VETLVVADKM
260 270 280 290 300
MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT
310 320 330 340 350
LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI
360 370 380 390 400
CIYKNKPCGT LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM
410 420 430 440 450
NHDGVGNSCG ARGQDPAKLM AAHITMKTNP FVWSSCSRDY ITSFLDSGLG
460 470 480 490 500
LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR FQHGVKSRQC KYGEVCSELW
510 520 530 540 550
CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG SRPEGVDGAW
560 570 580 590 600
GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD
610 620 630 640 650
CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF
660 670 680 690 700
YTERAAAVVD GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG
710 720 730 740 750
DGSACETIEG VFSPASPGAG YEDVVWIPKG SVHIFIQDLN LSLSHLALKG
760 770 780 790 800
DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ GPDQVQSLEA LGPINASLIV
810 820 830 840 850
MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ CAGGSQVQAV
860 870 880 890 900
ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC
910 920 930 940 950
DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA
960 970 980 990 1000
LDWSECTPSC GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR
1010 1020 1030 1040 1050
RCPPARWVAG EWGECSAQCG VGQRQRSVRC TSHTGQASHE CTEALRPPTT
1060 1070 1080 1090 1100
QQCEAKCDSP TPGDGPEECK DVNKVAYCPL VLKFQFCSRA YFRQMCCKTC

HGH
Length:1,103
Mass (Da):120,860
Last modified:January 7, 2015 - v1
Checksum:i66B89F08A74D5990
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H324ATS10_HUMAN
A disintegrin and metalloproteinase...
ADAMTS10
1,103Annotation score:
M0QY36M0QY36_HUMAN
A disintegrin and metalloproteinase...
ADAMTS10
289Annotation score:
M0QY12M0QY12_HUMAN
A disintegrin and metalloproteinase...
ADAMTS10
126Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130469 Genomic DNA No translation available.
AC243312 Genomic DNA No translation available.
RefSeqiNP_112219.3, NM_030957.3
XP_016882827.1, XM_017027338.1
UniGeneiHs.657508

Genome annotation databases

EnsembliENST00000270328; ENSP00000270328; ENSG00000142303
ENST00000597188; ENSP00000471851; ENSG00000142303
GeneIDi81794
KEGGihsa:81794
UCSCiuc002mkj.3 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130469 Genomic DNA No translation available.
AC243312 Genomic DNA No translation available.
RefSeqiNP_112219.3, NM_030957.3
XP_016882827.1, XM_017027338.1
UniGeneiHs.657508

3D structure databases

SMRiA0A0A0MQW6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0A0MQW6
PRIDEiA0A0A0MQW6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270328; ENSP00000270328; ENSG00000142303
ENST00000597188; ENSP00000471851; ENSG00000142303
GeneIDi81794
KEGGihsa:81794
UCSCiuc002mkj.3 human

Organism-specific databases

CTDi81794
EuPathDBiHostDB:ENSG00000142303.13
HGNCiHGNC:13201 ADAMTS10
OpenTargetsiENSG00000142303
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
KOiK08625
OMAiLEACHGP
OrthoDBiEOG091G14M8

Miscellaneous databases

ChiTaRSiADAMTS10 human
GenomeRNAii81794

Gene expression databases

BgeeiENSG00000142303 Expressed in 204 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiA0A0A0MQW6 baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 5 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0MQW6_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MQW6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: October 10, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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