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Protein
Submitted name:

Inverted formin-2

Gene

INF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Inverted formin-2Imported
Gene namesi
Name:INF2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000203485.12
HGNCiHGNC:23791 INF2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203485

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0A0MQU1
PRIDEiA0A0A0MQU1

Expressioni

Gene expression databases

BgeeiENSG00000203485 Expressed in 207 organ(s), highest expression level in tibial nerve
ExpressionAtlasiA0A0A0MQU1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0A0MQU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 414FH2InterPro annotationAdd BLAST393
Domaini442 – 457WH2InterPro annotationAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili347 – 367Sequence analysisAdd BLAST21
Coiled coili389 – 418Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1922 Eukaryota
ENOG410XQR0 LUCA
GeneTreeiENSGT00760000118986

Family and domain databases

InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR027649 Inf2
IPR003124 WH2_dom
PANTHERiPTHR23213:SF5 PTHR23213:SF5, 1 hit
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit
PS51082 WH2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MQU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GMEEVIVAQV DHGLGSAWVP SHRRVNPPTL RMKKLNWQKL PSNVAREHNS
60 70 80 90 100
MWASLSSPDA EAVEPDFSSI ERLFSFPAAK PKEPTMVAPR ARKEPKEITF
110 120 130 140 150
LDAKKSLNLN IFLKQFKCSN EEVAAMIRAG DTTKFDVEVL KQLLKLLPEK
160 170 180 190 200
HEIENLRAFT EERAKLASAD HFYLLLLAIP CYQLRIECML LCEGAAAVLD
210 220 230 240 250
MVRPKAQLVL AACESLLTSR QLPIFCQLIL RIGNFLNYGS HTGDADGFKI
260 270 280 290 300
STLLKLTETK SQQNRVTLLH HVLEEAEKSH PDLLQLPRDL EQPSQAAGIN
310 320 330 340 350
LEIIRSEASS NLKKLLETER KVSASVAEVQ EQYTERLQAS ISAFRALDEL
360 370 380 390 400
FEAIEQKQRE LADYLCEDAQ QLSLEDTFST MKAFRDLFLR ALKENKDRKE
410 420 430 440 450
QAAKAERRKQ QLAEEEARRP RGEDGKPVRK GPGKQEEVCV IDALLADIRK
460 470 480 490 500
GFQLRKTARG RGDTDGGSKA ASMDPPRATE PVATSNPAGD PVGSTRCPAS
510 520 530 540 550
EPGLDATTAS ESRGWDLVDA VTPGPQPTLE QLEEGGPRPL ERRSSWYVDA
560 570 580 590 600
SDVLTTEDPQ CPQPLEGAWP VTLGDAQALK PLKFSSNQPP AAGSSRQDAK
610 620 630 640 650
DPTSLLGVLQ AEADSTSEGL EDAVHSRGAR PPAAGPGGDE DEDEEDTAPE
660 670 680 690 700
SALDTSLDKS FSEDAVTDSS GSGTLPRARG RASKGTGKRR KKRPSRSQEE
710
VPPDSDDNKT KKLCVIQ
Length:717
Mass (Da):78,826
Last modified:January 7, 2015 - v1
Checksum:i318C8E367F43E2CD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q27J81INF2_HUMAN
Inverted formin-2
INF2 C14orf151, C14orf173
1,249Annotation score:
Q8WYS3Q8WYS3_HUMAN
Inverted formin-2
INF2 pp9484
142Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583722 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000252527; ENSP00000252527; ENSG00000203485
UCSCiuc059fwk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583722 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0A0MQU1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0A0MQU1
PRIDEiA0A0A0MQU1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252527; ENSP00000252527; ENSG00000203485
UCSCiuc059fwk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000203485.12
HGNCiHGNC:23791 INF2
OpenTargetsiENSG00000203485
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1922 Eukaryota
ENOG410XQR0 LUCA
GeneTreeiENSGT00760000118986

Miscellaneous databases

ChiTaRSiINF2 human

Gene expression databases

BgeeiENSG00000203485 Expressed in 207 organ(s), highest expression level in tibial nerve
ExpressionAtlasiA0A0A0MQU1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR027649 Inf2
IPR003124 WH2_dom
PANTHERiPTHR23213:SF5 PTHR23213:SF5, 1 hit
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit
PS51082 WH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0MQU1_HUMAN
AccessioniPrimary (citable) accession number: A0A0A0MQU1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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