UniProtKB - A0A0A0MQR4 (A0A0A0MQR4_HUMAN)
Protein
Submitted name:
Protein capicua homolog
Gene
CIC
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 200 – 268 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Protein capicua homologImported |
Gene namesi | Name:CICImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14214, CIC |
VEuPathDBi | HostDB:ENSG00000079432.7 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000079432, Expressed in right testis and 231 other tissues |
ExpressionAtlasi | A0A0A0MQR4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 268 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 201 | DisorderedSequence analysisAdd BLAST | 154 | |
Regioni | 270 – 311 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 326 – 365 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 381 – 438 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 470 – 630 | DisorderedSequence analysisAdd BLAST | 161 | |
Regioni | 686 – 719 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 785 – 804 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 890 – 909 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1129 – 1153 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1189 – 1431 | DisorderedSequence analysisAdd BLAST | 243 | |
Regioni | 1519 – 1606 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 50 – 75 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 99 – 113 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 134 – 152 | PolyampholyteSequence analysisAdd BLAST | 19 | |
Compositional biasi | 174 – 201 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 470 – 489 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 508 – 522 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 530 – 567 | PolarSequence analysisAdd BLAST | 38 | |
Compositional biasi | 890 – 905 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1131 – 1147 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1221 – 1253 | Pro-richSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1262 – 1277 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1284 – 1298 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1313 – 1327 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1334 – 1363 | PolyampholyteSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1390 – 1417 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1527 – 1556 | Pro-richSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1569 – 1606 | Pro-richSequence analysisAdd BLAST | 38 |
Phylogenomic databases
GeneTreei | ENSGT00940000159960 |
HOGENOMi | CLU_003486_0_0_1 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MQR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYSAHRPLMP ASSAASRGLG MFVWTNVEPR SVAVFPWHSL VPFLAPSQPD
60 70 80 90 100
PSVQPSEAQQ PASHPVASNQ SKEPAESAAV AHERPPGGTG SADPERPPGA
110 120 130 140 150
TCPESPGPGP PHPLGVVESG KGPPPTTEEE ASGPPGEPRL DSETESDHDD
160 170 180 190 200
AFLSIMSPEI QLPLPPGKRR TQSLSALPKE RDSSSEKDGR SPNKREKDHI
210 220 230 240 250
RRPMNAFMIF SKRHRALVHQ RHPNQDNRTV SKILGEWWYA LGPKEKQKYH
260 270 280 290 300
DLAFQVKEAH FKAHPDWKWC NKDRKKSSSE AKPTSLGLAG GHKETRERSM
310 320 330 340 350
SETGTAAAPG VSSELLSVAA QTLLSSDTKA PGSSSCGAER LHTVGGPGSA
360 370 380 390 400
RPRAFSHSGV HSLDGGEVDS QALQELTQMV SGPASYSGPK PSTQYGAPGP
410 420 430 440 450
FAAPGEGGAL AATGRPPLLP TRASRSQRAA SEDMTSDEER MVICEEEGDD
460 470 480 490 500
DVIADDGFGT TDIDLKCKER VTDSESGDSS GEDPEGNKGF GRKVFSPVIR
510 520 530 540 550
SSFTHCRPPL DPEPPGPPDP PVAFGKGYGS APSSSASSPA SSSASAATSF
560 570 580 590 600
SLGSGTFKAQ ESGQGSTAGP LRPPPPGAGG PATPSKATRF LPMDPATFRR
610 620 630 640 650
KRPESVGGLE PPGPSVIAAP PSGGGNILQT LVLPPNKEEQ EGGGARVPSA
660 670 680 690 700
PAPSLAYGAP AAPLSRPAAT MVTNVVRPVS STPVPIASKP FPTSGRAEAS
710 720 730 740 750
PNDTAGARTE MGTGSRVPGG SPLGVSLVYS DKKSAAATSP APHLVAGPLL
760 770 780 790 800
GTVGKAPATV TNLLVGTPGY GAPAPPAVQF IAQGAPGGGT TAGSGAGAGS
810 820 830 840 850
GPNGPVPLGI LQPGALGKAG GITQVQYILP TLPQQLQVAP APAPAPGTKA
860 870 880 890 900
AAPSGPAPTT SIRFTLPPGT STNGKVLAAT APTPGIPILQ SVPSAPPPKA
910 920 930 940 950
QSVSPVQAPP PGGSAQLLPG KVLVPLAAPS MSVRGGGAGQ PLPLVSPPFS
960 970 980 990 1000
VPVQNGAQPP SKIIQLTPVP VSTPSGLVPP LSPATLPGPT SQPQKVLLPS
1010 1020 1030 1040 1050
STRITYVQSA GGHALPLGTS PASSQAGTVT SYGPTSSVAL GFTSLGPSGP
1060 1070 1080 1090 1100
AFVQPLLSGQ APLLAPGQVG VSPVPSPQLP PACAAPGGPV ITAFYSGSPA
1110 1120 1130 1140 1150
PTSSAPLAQP SQAPPSLVYT VATSTTPPAA TILPKGPPAP ATATPAPTSP
1160 1170 1180 1190 1200
FPSATGSMTY SLVAPKAQRP SPKAPQKVKA AIASIPVGSF EAGASGRPGP
1210 1220 1230 1240 1250
APRQPLEPGP VREPTAPESE LEGQPTPPAP PPLPETWTPT ARSSPPLPPP
1260 1270 1280 1290 1300
AEERTSAKGP ETMASKFPSS SSDWRVPGQG LENRGEPPTP PSPAPAPAVA
1310 1320 1330 1340 1350
PGGSSESSSG RAAGDTPERK EAAGTGKKVK VRPPPLKKTF DSVDNRVLSE
1360 1370 1380 1390 1400
VDFEERFAEL PEFRPEEVLP SPTLQSLATS PRAILGSYRK KRKNSTDLDS
1410 1420 1430 1440 1450
APEDPTSPKR KMRRRSSCSS EPNTPKSAKC EGDIFTFDRT GTEAEDVLGE
1460 1470 1480 1490 1500
LEYDKVPYSS LRRTLDQRRA LVMQLFQDHG FFPSAQATAA FQARYADIFP
1510 1520 1530 1540 1550
SKVCLQLKIR EVRQKIMQAA TPTEQPPGAE APLPVPPPTG TAAAPAPTPS
1560 1570 1580 1590 1600
PAGGPDPTSP SSDSGTAQAA PPLPPPPESG PGQPGWEGAP QPSPPPPGPS
TAATGR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96RK0 | CIC_HUMAN | Protein capicua homolog | CIC KIAA0306 | 1,608 | Annotation score: | ||
I3L2J0 | I3L2J0_HUMAN | Protein capicua homolog | CIC | 2,514 | Annotation score: | ||
I3L1Q4 | I3L1Q4_HUMAN | Protein capicua homolog | CIC | 320 | Annotation score: | ||
I3L373 | I3L373_HUMAN | Protein capicua homolog | CIC | 144 | Annotation score: | ||
I3L135 | I3L135_HUMAN | Protein capicua homolog | CIC | 309 | Annotation score: | ||
I3L2I4 | I3L2I4_HUMAN | Protein capicua homolog | CIC | 144 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006486 Genomic DNA No translation available. |
RefSeqi | XP_005258730.1, XM_005258673.2 |
Genome annotation databases
Ensembli | ENST00000160740; ENSP00000160740; ENSG00000079432 |
GeneIDi | 23152 |
UCSCi | uc060zgk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006486 Genomic DNA No translation available. |
RefSeqi | XP_005258730.1, XM_005258673.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A0A0MQR4 |
Protocols and materials databases
Antibodypediai | 17427, 255 antibodies |
Genome annotation databases
Ensembli | ENST00000160740; ENSP00000160740; ENSG00000079432 |
GeneIDi | 23152 |
UCSCi | uc060zgk.1, human |
Organism-specific databases
CTDi | 23152 |
HGNCi | HGNC:14214, CIC |
OpenTargetsi | ENSG00000079432 |
VEuPathDBi | HostDB:ENSG00000079432.7 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159960 |
HOGENOMi | CLU_003486_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 23152, 19 hits in 900 CRISPR screens |
ChiTaRSi | CIC, human |
GenomeRNAii | 23152 |
Gene expression databases
Bgeei | ENSG00000079432, Expressed in right testis and 231 other tissues |
ExpressionAtlasi | A0A0A0MQR4, baseline and differential |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MQR4_HUMAN | |
Accessioni | A0A0A0MQR4Primary (citable) accession number: A0A0A0MQR4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | February 10, 2021 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |