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Entry version 30 (12 Aug 2020)
Sequence version 1 (07 Jan 2015)
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Protein
Submitted name:

Polycystic kidney disease protein 1-like 1

Gene

Pkd1l1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polycystic kidney disease protein 1-like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1l1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2156538, Pkd1l1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei983 – 1001HelicalSequence analysisAdd BLAST19
Transmembranei1189 – 1208HelicalSequence analysisAdd BLAST20
Transmembranei1228 – 1249HelicalSequence analysisAdd BLAST22
Transmembranei1367 – 1391HelicalSequence analysisAdd BLAST25
Transmembranei1397 – 1427HelicalSequence analysisAdd BLAST31
Transmembranei1707 – 1729HelicalSequence analysisAdd BLAST23
Transmembranei1741 – 1765HelicalSequence analysisAdd BLAST25
Transmembranei1785 – 1809HelicalSequence analysisAdd BLAST25
Transmembranei1861 – 1881HelicalSequence analysisAdd BLAST21
Transmembranei1888 – 1912HelicalSequence analysisAdd BLAST25
Transmembranei1935 – 1959HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046634, Expressed in epiblast (generic) and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A0MQP1, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 804REJInterPro annotationAdd BLAST804
Domaini1028 – 1145PLATInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni212 – 278DisorderedSequence analysisAdd BLAST67
Regioni1262 – 1295DisorderedSequence analysisAdd BLAST34
Regioni2044 – 2070DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi236 – 251PolarSequence analysisAdd BLAST16
Compositional biasi1265 – 1295PolarSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162104

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR014010, REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00308, LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MQP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LSQVQIKGSM VYSNYCVGVE VRARAPVSVI SEGTHIFIST ATSTFIILRG
60 70 80 90 100
AQSYDPDNPG AALRYHWTCT AASSPRWPCF DNSTSYQVDT QAPAISFPAK
110 120 130 140 150
WLSECCDQFL VTLTVSSRGQ NSSQALMFLS TRPDLAFRFV HISWVNFRDI
160 170 180 190 200
SVNWNEEVSL RAVCEDCGDV PDLTYSWDLF LVNATEKSAV EVPFCSTVGL
210 220 230 240 250
LGALALGTSL KSSKSDLPSN LRAPLTPHSP EPSPTPLGWT ALSNLGSISA
260 270 280 290 300
ESTAGGHHVP ASGAVAGSGE PMEEYSSLSS LAEEALMTNS SEGSWPSPSS
310 320 330 340 350
STDFDDFEAY YSDIQEAVLS LGRQPGTSTN FQEAGPSLSA EESASYGDNL
360 370 380 390 400
LGPFLHTGRA KPTLMIDWPK ALVSQAAFHG YTTSGIMGPA VTIKPFSLSS
410 420 430 440 450
GKTYVLQASV ASKHVLLGKA QLYLTVNQAP QDMSCQVRPH HGMEAYTIFS
460 470 480 490 500
VFCMSGKPDF HYEFRYRIGN TSSHTLYRGQ DTQHYFLLPA GDSSDNYKVI
510 520 530 540 550
VSTEITDGHG SKVQPCTVAV TVLPRYHGND CCDKELYNST LESLSTLRLA
560 570 580 590 600
GSYMETRNYI TMITGILSRL YVESRNTSSC GQWSQIQDVL ISSACKVPYT
610 620 630 640 650
DQEGMMDSIH ILRDLISFPN KLSLTSAMCI FKYTKMFLAQ GQFSRRLLVD
660 670 680 690 700
KKLRVEFVLL ISGVWEAAKE DARDGDYLQE EGMKIISDML LIHVSTGQME
710 720 730 740 750
FQTLLHRSPQ SSIQNLGFVQ VHFPSDLASL HSTTQEATQS SCYISQLMFF
760 770 780 790 800
MKSPYLGGQV PGQVGGVMIP RLYSCESRRP ILRGQLETPV TMEFGEEDYL
810 820 830 840 850
HKRNPAMFVL LRDEVNVHRF TGLSENSQES LQIHIKFSKP VTRPFPIILL
860 870 880 890 900
VRFSEKATPS DFLVKRVYFW DEQTVQMYVP AAPWKGANVG YLSLLDADYD
910 920 930 940 950
RKPPNKYLAG AVNYTVHFQW IQCVFWDKTE WRSEGPYPQP GSSPEKVNCS
960 970 980 990 1000
YHHLAPVSVL RRKLNATLEV SSISEFQSHP HNLLPGIFSA FLLVLYGILV
1010 1020 1030 1040 1050
SKSRYVDCHE KKNPGFIFLE EDTLPGYQLY AVVIDTGFRS PVRFTSKVFI
1060 1070 1080 1090 1100
VLCGENGCSE TKELCCPEKP LFGRNSRHTF ILSIPNQLGP LQKIRLWHDS
1110 1120 1130 1140 1150
SGSSPCWFIS HVMVKELCSG QAWFFSAQCW LAVSKLGGHV LREFFCLSHG
1160 1170 1180 1190 1200
LGFWKLFYSK FTEYLEDFHI WLSLYSQPPS RSYLHTQRLA VSFCLLCVYS
1210 1220 1230 1240 1250
CLTALVTVRD HQQRPLDVGP TAITLEPFCM ALLCTLLACP VAQLLSLLFR
1260 1270 1280 1290 1300
CSKEARGDMQ ASTQWPLRGV KTETPQGHDS SGRPDSRQPS PHPTSDLLPW
1310 1320 1330 1340 1350
NDQAWRIAAS SSAVVCSPFP MEACSHKHHD LREKSHYSPP SSQAPGSGFE
1360 1370 1380 1390 1400
ELGSQKSRVC LLWSSSVAWA ISGSASLACG LGTGFLGYWF VPAQCMWWLY
1410 1420 1430 1440 1450
LLLLSLVCCA FITQPLMICL AALVFAWKRK HDSKFFTESL QDATKGLDLE
1460 1470 1480 1490 1500
LEEHSRTRVP LSPISYSPDT AEEAERVLAT RQRERHLRWA QTPSKAKLRV
1510 1520 1530 1540 1550
TGERLRRESI MQAALRDMTT HSIMLLLLLF IAYGRFCPGE ISLNHAIRKA
1560 1570 1580 1590 1600
FTRKANHSLG DLSSTEDWWD WTLSTLLDEL YPERTSARAW GAQPGALGGQ
1610 1620 1630 1640 1650
CHLIGPPVVK LLKISAGTAC TPPRPFSELV EDVLPMHSND LDLENQNVSP
1660 1670 1680 1690 1700
GGPETCGVKK ESYMHSLGKT RHEAHAALTA LRASKWIDHS TRAMSVHFTL
1710 1720 1730 1740 1750
YNPPTQLFTS VILGTECLPS GGLVPSFLVE SFRIFYSDSA LKYLLMLSEL
1760 1770 1780 1790 1800
LFLVLNVIHL CFQLWGMTTK GILSYWRKPR HWLELSMVGV AIAYYAASGH
1810 1820 1830 1840 1850
LTTLAVNITD QFHKGLYQRL VDIGLMVSWH QRARCLQGIL LFLWMLKYVH
1860 1870 1880 1890 1900
LLSSLSTMTP FSAVTCFPLF RVLLVGALLL AAHYHSRWFL LFTGTLSHGT
1910 1920 1930 1940 1950
SAEAFPGLLL QFPGRSKKDS WHNCLKSDHG VMRCYYGTLF LLLATLGFRM
1960 1970 1980 1990 2000
LRATFLTVFQ NRKSSHRKPL VTLKDIAVYT WHKVLTLLGL ETTLEETEVA
2010 2020 2030 2040 2050
TDHIYYLDEF SSLLDELLMK IDGLSDSLEL SILENQWKRA LESRAGDSPP
2060 2070
VGSSEYQATG VSGPLAAESE
Length:2,070
Mass (Da):230,992
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6856A93EBA3A6CE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R526PK1L1_MOUSE
Polycystic kidney disease protein 1...
Pkd1l1 Rks
2,615Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQK4A0A0A0MQK4_MOUSE
Polycystic kidney disease protein 1...
Pkd1l1
2,521Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645571 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000178195; ENSMUSP00000136518; ENSMUSG00000046634

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645571 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13627, 54 antibodies

Genome annotation databases

EnsembliENSMUST00000178195; ENSMUSP00000136518; ENSMUSG00000046634

Organism-specific databases

MGIiMGI:2156538, Pkd1l1

Phylogenomic databases

GeneTreeiENSGT00940000162104

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pkd1l1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046634, Expressed in epiblast (generic) and 40 other tissues
ExpressionAtlasiA0A0A0MQP1, baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR014010, REJ_dom
PfamiView protein in Pfam
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
SMARTiView protein in SMART
SM00308, LH2, 1 hit
SUPFAMiSSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A0MQP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A0MQP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: August 12, 2020
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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