UniProtKB - A0A0A0MQI9 (A0A0A0MQI9_MOUSE)
Protein
F-actin-capping protein subunit beta
Gene
Capzb
Organism
Mus musculus (Mouse)
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.UniRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- barbed-end actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit betaUniRule annotation |
Gene namesi | Name:CapzbImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104652, Capzb |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Other locations
- sarcomere ARBA annotation
Cytoskeleton
- F-actin capping protein complex Source: UniProtKB-UniRule
Other locations
- sarcomere Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000028745, Expressed in placenta and 309 other tissues |
ExpressionAtlasi | A0A0A0MQI9, baseline and differential |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000017957 |
OMAi | GRQAHYK |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MQI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA
60 70 80 90 100
RDKVVGKDYL LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA
NNAFDQYRD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP47757 | CAPZB_MOUSE | F-actin-capping protein subunit bet... | Capzb Cappb1 | 277 | Annotation score: | ||
A2AMW0 | A2AMW0_MOUSE | F-actin-capping protein subunit bet... | Capzb | 260 | Annotation score: | ||
F7CAZ6 | F7CAZ6_MOUSE | F-actin-capping protein subunit bet... | Capzb | 204 | Annotation score: | ||
F6YHZ8 | F6YHZ8_MOUSE | F-actin-capping protein subunit bet... | Capzb | 188 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 109 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL807811 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000145368; ENSMUSP00000119252; ENSMUSG00000028745 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL807811 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0A0MQI9 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A0A0A0MQI9 |
Protocols and materials databases
Antibodypediai | 7956, 280 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000145368; ENSMUSP00000119252; ENSMUSG00000028745 |
Organism-specific databases
MGIi | MGI:104652, Capzb |
Phylogenomic databases
GeneTreei | ENSGT00390000017957 |
OMAi | GRQAHYK |
Miscellaneous databases
ChiTaRSi | Capzb, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028745, Expressed in placenta and 309 other tissues |
ExpressionAtlasi | A0A0A0MQI9, baseline and differential |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MQI9_MOUSE | |
Accessioni | A0A0A0MQI9Primary (citable) accession number: A0A0A0MQI9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | October 5, 2016 | |
Last modified: | October 7, 2020 | |
This is version 38 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |