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Entry version 46 (12 Aug 2020)
Sequence version 1 (07 Jan 2015)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1

Gene

Macf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi4988 – 4999PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi5024 – 5035PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108559, Macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneARBA annotation, Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, Membrane, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A0A0MQA6

PRoteomics IDEntifications database

More...
PRIDEi
A0A0A0MQA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028649, Expressed in lung and 330 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A0MQA6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0A0MQA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 181Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini194 – 298Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini868 – 925SH3InterPro annotationAdd BLAST58
Domaini4975 – 5010EF-handInterPro annotationAdd BLAST36
Domaini5011 – 5046EF-handInterPro annotationAdd BLAST36
Domaini5051 – 5129GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni4878 – 4911DisorderedSequence analysisAdd BLAST34
Regioni5145 – 5328DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili245 – 265Sequence analysisAdd BLAST21
Coiled coili477 – 497Sequence analysisAdd BLAST21
Coiled coili502 – 529Sequence analysisAdd BLAST28
Coiled coili821 – 841Sequence analysisAdd BLAST21
Coiled coili1046 – 1066Sequence analysisAdd BLAST21
Coiled coili1403 – 1433Sequence analysisAdd BLAST31
Coiled coili1522 – 1549Sequence analysisAdd BLAST28
Coiled coili1629 – 1656Sequence analysisAdd BLAST28
Coiled coili1782 – 1820Sequence analysisAdd BLAST39
Coiled coili2047 – 2074Sequence analysisAdd BLAST28
Coiled coili2081 – 2101Sequence analysisAdd BLAST21
Coiled coili2121 – 2148Sequence analysisAdd BLAST28
Coiled coili2159 – 2179Sequence analysisAdd BLAST21
Coiled coili2187 – 2214Sequence analysisAdd BLAST28
Coiled coili2227 – 2254Sequence analysisAdd BLAST28
Coiled coili2292 – 2312Sequence analysisAdd BLAST21
Coiled coili2557 – 2577Sequence analysisAdd BLAST21
Coiled coili2671 – 2691Sequence analysisAdd BLAST21
Coiled coili2764 – 2784Sequence analysisAdd BLAST21
Coiled coili2808 – 2828Sequence analysisAdd BLAST21
Coiled coili2915 – 2970Sequence analysisAdd BLAST56
Coiled coili3107 – 3127Sequence analysisAdd BLAST21
Coiled coili3133 – 3153Sequence analysisAdd BLAST21
Coiled coili3788 – 3808Sequence analysisAdd BLAST21
Coiled coili4021 – 4048Sequence analysisAdd BLAST28
Coiled coili4800 – 4820Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 28PolyampholyteSequence analysisAdd BLAST21
Compositional biasi5164 – 5238PolarSequence analysisAdd BLAST75
Compositional biasi5275 – 5328PolarSequence analysisAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000015_1_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR029926, Dystonin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 3 hits
PTHR23169:SF24, PTHR23169:SF24, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All

A0A0A0MQA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH
60 70 80 90 100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN
110 120 130 140 150
DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ
160 170 180 190 200
VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL
210 220 230 240 250
LLWTQKVTAG YTGVKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQVQS
260 270 280 290 300
NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV
310 320 330 340 350
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI RQHTILMSDK SFPQNPVELK
360 370 380 390 400
ALYNQYIHFK ETEILAKERE KGRIKELYKL LEVWIEFGRI KLPQGYHPNH
410 420 430 440 450
VEEEWGKLIV EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA
460 470 480 490 500
KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDEKYY
510 520 530 540 550
QLEELAFRVM RLQDELVTLR LECTNLYRKG HFSSLELVPP STLTTTHLKA
560 570 580 590 600
EPLNKTTHSS STSWFRKPMT RTELVSISSS EDEGNLRFVY ELLSWVEEMQ
610 620 630 640 650
MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF
660 670 680 690 700
HTSYVETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNGKE
710 720 730 740 750
EEELACDWSD SNPNISAKKT YFSELTMELE GKQDVFRSLQ DTAEVLSLEN
760 770 780 790 800
HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENAAYFQ FFSDARDLES
810 820 830 840 850
FLRNLQDSIK RKYTCDRSTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG
860 870 880 890 900
RSKTIVQLKP RNPDHVLKST LSVKAICDYR QIEITICKND ECVLEDNSQR
910 920 930 940 950
TKWKVISPTG NEAMVPSVCF LIPPPNKEAI EMASRVEQSY QKVMALWHQL
960 970 980 990 1000
HINTKSLISW NYLRKDLDTV QTWSLEKLRS LAPGECHQVM KNLQAHYEDF
1010 1020 1030 1040 1050
LQDSHDSALF SVADRLRIEE EVEACKAHFQ HLMKSLENED KEETLAKVYI
1060 1070 1080 1090 1100
SELKNIRLLL EECEQRLLKQ IQSPASSKTD RDARQDITLR IAEQEHTQED
1110 1120 1130 1140 1150
LQHLRSDLDA ISMKCNVFLQ QSPSGSSATT LRSELNLMVE KMDHVYGLST
1160 1170 1180 1190 1200
VYLNKLKTID VIVRSMQDAE LLVKGYEIKL SQEEAVPADL SALESHRTTL
1210 1220 1230 1240 1250
QHWLSDVKDK NSVFSVLDEE ITKAKKVAEQ LRHPASEPNL DLERYQEKGS
1260 1270 1280 1290 1300
QLQERWHRVI AQLETRQSEV ESIQEVLRDY RACHGTLIKW IEETTAQQEM
1310 1320 1330 1340 1350
MKPGQAEDSR VLSEQLSQQT ELFAEIERNQ TKLDQCQKFS QQYSTIVKDY
1360 1370 1380 1390 1400
ELQLMTYKAF VESQQKSPGK RRRMISSSDA ITQEFMDLRT RYTALVTLTT
1410 1420 1430 1440 1450
QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKDLLGWVST LARNTQGTTT
1460 1470 1480 1490 1500
SSHTSASADI EKAILEQQVL AEELTTKKEQ VSEAIKTSQI FLAKHGHKLS
1510 1520 1530 1540 1550
EGEKEQISEQ LRVLNKTYHD LCDGSANQLQ QLQSELAQQT EQKTLQKQQD
1560 1570 1580 1590 1600
TCHKKLEDLC NWVGQAERAL ERHQGGASRQ ELPALQQNQS DLKDLQGDIQ
1610 1620 1630 1640 1650
SHSTSFATAV KDIEGFLEEN QTKLSPQELT ALREKLHQAK EQYEVLQERT
1660 1670 1680 1690 1700
RVAQKELEEA VTSALQQETE KSKAATELAE NKRKIDALLD WVASVGSSER
1710 1720 1730 1740 1750
KPQASLPGME QFSGACLEKQ TLAATDGHVD VNQVPETLDR QYELMKARHQ
1760 1770 1780 1790 1800
ELLSQQQNFI VATQSVQSFL DQHSHNLTPE ERQKLQEKLG ELKEQYAASL
1810 1820 1830 1840 1850
ARSEAELKQT QALRDELQKF LQDHKEFENW LQQSENELDS MHKGGSSPEA
1860 1870 1880 1890 1900
LNSLLKRQGS FSEDVISHKG DLRFVTISGQ KVLETENNFE EGQEPSATRN
1910 1920 1930 1940 1950
LVNEKLKDAT ERYTTLHSKC IRLGSHLSML LGQYQQFQSS ADSLQAWVLT
1960 1970 1980 1990 2000
CEASVGKLLS DTVASDPGVL QQQLATTKQL QEELAEHQVP VEKLQKAAHD
2010 2020 2030 2040 2050
LLDIEGEPAL DCRPIQETTD SISSRFQNLS CSLDERSALL QKAIAQSQSV
2060 2070 2080 2090 2100
QESMESLLQS IREVEQNLER DQVASLSSGV IQEALANNMK LKQDIARQKS
2110 2120 2130 2140 2150
SLEATHDMVT RFMETADSNS ASVLQGKLAE LSQRFQQLQL QQQEKESNLK
2160 2170 2180 2190 2200
KLLPQAEMFE QLSNKLQQFM ENKSRLLASG NQPDQDIAHF SQQIQELTLA
2210 2220 2230 2240 2250
MEDQKENLDT LEHLVTTLGS CGFALDLSQH QDKIQNLKKD FTELQKTVQE
2260 2270 2280 2290 2300
REKDASTCQE QLDEFRKLIR TFQKWLKETE GNVPPAKTFV SAKELEKQIE
2310 2320 2330 2340 2350
HLKDLISDWE SKGALLGEIN AKGTALESLI MDITAPDSQA KTGSILPPVG
2360 2370 2380 2390 2400
SSVGSVNGYH TCKDLTEIQC DMFDVNSKYE KLWEVLRERQ ESLQTVFSRM
2410 2420 2430 2440 2450
EEVQKEASSV LQWLESKEEV LKAMDATLSP TKTETVKAQA ESNKAFLAEL
2460 2470 2480 2490 2500
EQNSPKIQKV KEALAGLLKT YPNSQEAENW KKMQEDLNSR WEKATEVTVA
2510 2520 2530 2540 2550
RQKQLEESAS HLACFQAAES QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK
2560 2570 2580 2590 2600
QQVQFMLKEF EARRQQHEQL NEAAQGILTG PGDMSPSASQ VHKDLQSISQ
2610 2620 2630 2640 2650
KWVELTDKLN SRSSQIDQAI VKSTQYQDLL QDLSEKVKAI GQRLSGQSAI
2660 2670 2680 2690 2700
STQPEAVKQQ LEETSEIRSD LGQLDNEIKE AQTLCQELSL LIGEQYLKDE
2710 2720 2730 2740 2750
LKKRLETVAL PLQGLEDLAA DRMNRLQAAL ASTQQFQQMF DELRTWLDEK
2760 2770 2780 2790 2800
QSQQAKNCPI SAKLERLQCQ LQENEEFQKN LNQHSGSYEV IVAEGEALLL
2810 2820 2830 2840 2850
SVPPGEEKKT LQNQLVELRS HWEDLSKKTA NRQSRLKDCM QKAQKYQGHV
2860 2870 2880 2890 2900
EDLVPWIDEC KSKMSELQVT LDPVQLESSL LRSKAMLNEA EKRRSLLEIL
2910 2920 2930 2940 2950
NSAADILINS SEIDEDEIRD EKAGLNQNMD AITEELQAKT SSLEEMTQRL
2960 2970 2980 2990 3000
KEFQESFKNI EKKVEGAKHQ LEIFDALGSQ ACSNKNLEKL KAQQEVLQAL
3010 3020 3030 3040 3050
EPQVDYLRNF TQGLVEDAPD GSDASPLVHQ AEVAQQEFLE VKQRVSSSCL
3060 3070 3080 3090 3100
TMENKLEGIG QFHCRVREMF SQLADLDDEL DGMGAIGRDT DSLQSQIEDV
3110 3120 3130 3140 3150
RLFLNKIQAL RFDIEDSEAE CRKMLEEEGT LDLLGLKREL EALNKQCGKL
3160 3170 3180 3190 3200
TERGKVRQEQ LELTLGRVED FYRKLKALND AATAAEEGEA LQWIVGTEVD
3210 3220 3230 3240 3250
VINQQLADFK LFQKDQVDPL QVKLQQVNGL GQGLIQSAGK NCDVQGLEHD
3260 3270 3280 3290 3300
MDEINTRWNT LNKKVAQRIA QLQEALLHCG KFQDALEPLL SWLTDTEELI
3310 3320 3330 3340 3350
ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR KATVDMLQAE GGRIAQSAEL
3360 3370 3380 3390 3400
ADREKITGQL ESLERRWTDL LSKAAARQKQ LEDILVLAKQ FHETAEPISD
3410 3420 3430 3440 3450
FLSVTEKKLA NSEPVGTQTA KIHQQIIRHK ALNEEIINRK KNVDQAIKNG
3460 3470 3480 3490 3500
QALLKQTTGE EVLLIQEKLD GIKTRYADIT LTSSKALRTL EQARQLATKF
3510 3520 3530 3540 3550
HSTYEELTGW LREAEEELAA SGGQSPTGEQ IPQFQQRQKE LKKEVMEHRL
3560 3570 3580 3590 3600
VLDTVNEVSH ALLELVPWRA REGLDKLVSD ANEQYKLISD TVGQRVDEID
3610 3620 3630 3640 3650
AAIQRSQQYE QAADAELAWV AETKRKLMAL GPIRLEQDQT TAQLQVQKAF
3660 3670 3680 3690 3700
SIDIIRHKDS MDELFSHRGE IFSTCGEEQK AVLQEKTECL IQQYEAVSLL
3710 3720 3730 3740 3750
NSERYARLER AQVLVNQFWE TYEELSPWAE ETLALIAQLP PPAVDHEQLR
3760 3770 3780 3790 3800
QQQEEMRQLR ESIAEHKPHI DKILKIGPQL KELNPEEGKM VEEKYQKAEN
3810 3820 3830 3840 3850
MYAQIKDEVR QRALALDEAV SQSAQFHDKI EPMLETLENL SSRLRMPPLI
3860 3870 3880 3890 3900
PAEVDKIREC ISDNKSATVE LEKLQPSFEA LKRRGEELIG RSQGADKDLA
3910 3920 3930 3940 3950
AKEIQDKLDQ MVFFWEDIKA RSEEREIKFL DVLELAEKFW YDMAALLTTI
3960 3970 3980 3990 4000
KDTQDIVHDL ESPGIDPSII KQQVEAAETI KEETDGLHEE LEFIRILGAD
4010 4020 4030 4040 4050
LIFACGETEK PEVKKSIDEM NNAWENLNKT WKERLEKLED AMQAAVQYQD
4060 4070 4080 4090 4100
TLQAMFDWLD NTVIKLCTMP PVGTDLNTVK DQLNEMKEFK VEVYQQQIEM
4110 4120 4130 4140 4150
EKLNHQGELM LKKATDETDR DIIREPLTEL KHLWENLGEK IAHRQHKLEG
4160 4170 4180 4190 4200
ALLALGQFQH ALEELMSWLT HTEELLDAQR PISGDPKVIE VELAKHHVLK
4210 4220 4230 4240 4250
NDVLAHQATV ATVNKAGSEL LESSAGDDAS SLRSRLETMN QCWESVLQKT
4260 4270 4280 4290 4300
EEREQQLQST LQQAQGFHSE IEDFLLELNR MENQLSASKP TGGLPETARE
4310 4320 4330 4340 4350
QLDTHMELHS QLRAKEEIYN QLLDKGRLML LSRGDSGSGS KTEQSVALLE
4360 4370 4380 4390 4400
QKWHAVSSKV EERKSKLEEA LSLATEFQNS LQEFINWLTL AEQSLNIASP
4410 4420 4430 4440 4450
PSLILNTVLS QIEEHKVFAN EVNDHRDQII ELDQTGNQLK FLSQKQDVVL
4460 4470 4480 4490 4500
IKNLLVSVQS RWEKVVQRSI ERGRSLDDAR KRAKQFHEAW KKLIDWLEDA
4510 4520 4530 4540 4550
ESHLDSELEI SNDPDKIKLQ LSKHKEFQKT LGGKQPVYDT TIRTGRALKE
4560 4570 4580 4590 4600
KTLLAGDTQK LDNLLGEVRD KWDTVCGKSV ERQHKLEEAL LFSGQFMDAL
4610 4620 4630 4640 4650
QALVDWLYKV EPQLAEDQPV HGDLDLVMNL MDAHKVFQKE LGKRTGTVQV
4660 4670 4680 4690 4700
LKRSGRELIE GSRDDTTWVK GQLQELSTRW DTVCKLSVSK QSRLEQALKQ
4710 4720 4730 4740 4750
AEEFRDTVHM LLEWLSEAEQ TLRFRGALPD DTEALQSLID THKEFMKKVE
4760 4770 4780 4790 4800
EKRVDVNTAV AMGEAILAVC HPDCITTIKH WITIIRARFE EVLTWAKQHQ
4810 4820 4830 4840 4850
QRLETALSEL VANAELLEEL LAWIQWAETT LIQRDQEPIP QNIDRVKALI
4860 4870 4880 4890 4900
TEHQSFMEEM TRKQPDVDRV TKTYKRKSVE PTHAPFMEKS RSGSRKSLNQ
4910 4920 4930 4940 4950
PTPPPMPILS QSEAKNPRIN QLSARWQQVW LLALERQRKL NDALDRLEEL
4960 4970 4980 4990 5000
CPELKEFANF DFDVWRKKYM RWMNHKKSRV MDFFRRIDKD QDGKITRQEF
5010 5020 5030 5040 5050
IDGILASKFP TTKLEMTAVA DIFDRDGDGY IDYYEFVAAL HPNKDAYRPT
5060 5070 5080 5090 5100
TDADKIEDEV TRQVAQCKCA KRFQVEQIGE NKYRFFLGNQ FGDSQQLRLV
5110 5120 5130 5140 5150
RILRSTVMVR VGGGWMALDE FLVKNDPCRA RGRTNIELRE KFILPEGASQ
5160 5170 5180 5190 5200
GMTPFRSRGR RSKPSSRAAS PTRSSSSASQ SNHSCTSMPS SPATPASGTK
5210 5220 5230 5240 5250
VISSSGSKLK RPTPAFHSSR TSLAGDTSNS SSPASTGAKA NRADPKKSAS
5260 5270 5280 5290 5300
RPGSRAGSRA GSRASSRRGS DASDFDLLET QSACSDTSES SAAGGQGSSR
5310 5320
RGLTKPSKIP TMSKKTTTAS PRTPGPKR
Length:5,328
Mass (Da):607,892
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i516F7337369E7B49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QXZ0MACF1_MOUSE
Microtubule-actin cross-linking fac...
Macf1 Acf7, Aclp7, Macf
7,354Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVY8E9PVY8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,355Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU4B1ARU4_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ACR9F7ACR9_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA63E9QA63_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QNP1E9QNP1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BF93A0A571BF93_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,323Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BGC6A0A571BGC6_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q750F6Q750_MOUSE
Microtubule-actin cross-linking fac...
Macf1
4,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YKN8F6YKN8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001186066.1, NM_001199137.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000082108; ENSMUSP00000080755; ENSMUSG00000028649

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11426

UCSC genome browser

More...
UCSCi
uc008upl.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.
RefSeqiNP_001186066.1, NM_001199137.1

3D structure databases

SMRiA0A0A0MQA6
ModBaseiSearch...

Proteomic databases

jPOSTiA0A0A0MQA6
PRIDEiA0A0A0MQA6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31853, 59 antibodies

Genome annotation databases

EnsembliENSMUST00000082108; ENSMUSP00000080755; ENSMUSG00000028649
GeneIDi11426
UCSCiuc008upl.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23499
MGIiMGI:108559, Macf1

Phylogenomic databases

GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_1_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11426, 4 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Macf1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028649, Expressed in lung and 330 other tissues
ExpressionAtlasiA0A0A0MQA6, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR029926, Dystonin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 3 hits
PTHR23169:SF24, PTHR23169:SF24, 3 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A0MQA6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A0MQA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: August 12, 2020
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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