UniProtKB - A0A0A0MQ87 (A0A0A0MQ87_MOUSE)
Protein
Submitted name:
Son of sevenless homolog 2
Gene
Sos2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- positive regulation of small GTPase mediated signal transduction Source: Ensembl
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Son of sevenless homolog 2Imported |
Gene namesi | Name:Sos2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98355, Sos2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034801, Expressed in membranous labyrinth and 299 other tissues |
ExpressionAtlasi | A0A0A0MQ87, baseline and differential |
Interactioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 199 – 388 | DHInterPro annotationAdd BLAST | 190 | |
Domaini | 441 – 544 | PHInterPro annotationAdd BLAST | 104 | |
Domaini | 595 – 739 | N-terminal Ras-GEFInterPro annotationAdd BLAST | 145 | |
Domaini | 778 – 1017 | Ras-GEFInterPro annotationAdd BLAST | 240 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1018 – 1060 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 1076 – 1098 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1140 – 1332 | DisorderedSequence analysisAdd BLAST | 193 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 888 – 908 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1151 – 1165 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1173 – 1188 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1197 – 1225 | Pro-richSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1271 – 1285 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1287 – 1301 | Pro-richSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158324 |
OMAi | KVEHWDD |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.20.10, 1 hit 1.10.840.10, 2 hits 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF00169, PH, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48065, SSF48065, 1 hit SSF48366, SSF48366, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A0A0MQ87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQAPQPYEF FSEENSPKWR GLLVPALRKV QEQVHPTLSA NEESLYYIEE
60 70 80 90 100
LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF
160 170 180 190 200
NIRHYEISQQ DIKVSMCADK VLMDMFDQDD DIGLVSLCED EPCSSGELNY
210 220 230 240 250
YDLVRTEIAE ERQYLRELNM IIKVFREAFL LDRKLFKPSE IEKIFSNISD
260 270 280 290 300
IHELTVKLLG LIEDTVEMTD ESSPHPLAGS CFEDLAEEQA FDPYETLSQD
310 320 330 340 350
ILAPEFNDHF SKLMARPAVA LHFQSIADGF KEAVRYVLPR LMLVPVYHCW
360 370 380 390 400
HYFELLKLKA CSEEQEDKEC LNQAITALMN LQGSMDRIYK QHSPRRRPGD
410 420 430 440 450
PVCLFYNRQL RSKHLAIKKM NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR
460 470 480 490 500
IGAKHERHIF LFDGLMISCK PNHGQTRLPG YSSAEYRLKE KFVMRKIQIC
510 520 530 540 550
DKEDACEYRH AFELVSKDEN SVIFAAKSAE EKNNWMAALI SLHYRSTLDR
560 570 580 590 600
MLDSVLLKEE NEQPLRLPSP DMYRFVVTDS EENIVFEDNL QSRSGIPIIK
610 620 630 640 650
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLN LLIERFEIPE
660 670 680 690 700
PEPTEADKLA LEKGEQPISA DLKRFRKEYV QPVQLRVLNV FRHWVEHHYY
710 720 730 740 750
DFERDLELLE RLESFISSVR GKAMKKWVES IAKIIKRKKQ AQANGISHNI
760 770 780 790 800
TFESSPPPVE WHISRTGQFE TFDLMTLHPI EIARQLTLLE SDLYRKVQPS
810 820 830 840 850
ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA ENFEERVAVL
860 870 880 890 900
SRIVEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRRILD
910 920 930 940 950
DAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNSDFLKRKG
960 970 980 990 1000
KDLINFSKRR KVAEITGEIQ QYQNQPYCLR TEPEMRRFFE NLNPMGILSE
1010 1020 1030 1040 1050
KEFTDYLFNK SLEIEPRNCK QPPRFPRKST FSLKSPGIRP NAGRHGSTSG
1060 1070 1080 1090 1100
TLRGHPTPLE REPYKISFSR IAETELESTV SAPTSPNTPS TPPVSASSDH
1110 1120 1130 1140 1150
SVFLDVDLNS SCGSNTIFAP VLLPHSKTFF SSCGSLHKLS EEPLIPPPLP
1160 1170 1180 1190 1200
PRKKFDHDAL NSKGAVKSDD DPPAIPPRQP PPPKVKPRVP VLMGTFDGPV
1210 1220 1230 1240 1250
PSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HPHRDPDWLR
1260 1270 1280 1290 1300
DVSTCPNSPS TPPTTPSPRI PRSCHLLSSS HSSLAHLPAP PVPPRQNSSP
1310 1320 1330
LLPKLPPKTY KRELSHPPLY RLPLLENAET PQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ02384 | SOS2_MOUSE | Son of sevenless homolog 2 | Sos2 | 1,333 | Annotation score: | ||
S4R2C4 | S4R2C4_MOUSE | Son of sevenless homolog 2 | Sos2 | 1,300 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133949 Genomic DNA No translation available. AC141560 Genomic DNA No translation available. AC153658 Genomic DNA No translation available. |
RefSeqi | NP_001129031.1, NM_001135559.1 |
Genome annotation databases
Ensembli | ENSMUST00000035773; ENSMUSP00000044866; ENSMUSG00000034801 |
GeneIDi | 20663 |
KEGGi | mmu:20663 |
UCSCi | uc007nso.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133949 Genomic DNA No translation available. AC141560 Genomic DNA No translation available. AC153658 Genomic DNA No translation available. |
RefSeqi | NP_001129031.1, NM_001135559.1 |
3D structure databases
SMRi | A0A0A0MQ87 |
ModBasei | Search... |
PTM databases
iPTMneti | A0A0A0MQ87 |
Protocols and materials databases
Antibodypediai | 3885, 154 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035773; ENSMUSP00000044866; ENSMUSG00000034801 |
GeneIDi | 20663 |
KEGGi | mmu:20663 |
UCSCi | uc007nso.2, mouse |
Organism-specific databases
CTDi | 6655 |
MGIi | MGI:98355, Sos2 |
Phylogenomic databases
GeneTreei | ENSGT00940000158324 |
OMAi | KVEHWDD |
Miscellaneous databases
BioGRID-ORCSi | 20663, 0 hits in 15 CRISPR screens |
ChiTaRSi | Sos2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034801, Expressed in membranous labyrinth and 299 other tissues |
ExpressionAtlasi | A0A0A0MQ87, baseline and differential |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.20.10, 1 hit 1.10.840.10, 2 hits 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF00169, PH, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48065, SSF48065, 1 hit SSF48366, SSF48366, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A0MQ87_MOUSE | |
Accessioni | A0A0A0MQ87Primary (citable) accession number: A0A0A0MQ87 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 7, 2015 |
Last sequence update: | January 7, 2015 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |