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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Clostridium botulinum C/D str. DC5
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
ORF Names:Z955_00370Imported
OrganismiClostridium botulinum C/D str. DC5Imported
Taxonomic identifieri1443128 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000030014 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei47 – 68HelicalUniRule annotationAdd BLAST22
Transmembranei74 – 92HelicalUniRule annotationAdd BLAST19
Transmembranei112 – 128HelicalUniRule annotationAdd BLAST17
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei172 – 193HelicalUniRule annotationAdd BLAST22
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 259HelicalUniRule annotationAdd BLAST29
Transmembranei298 – 318HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A0ILS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMIYSVLV AFILSLLQGP ILIPLLHKFK FGQNIRSEGP QSHKKKSGTP
60 70 80 90 100
TMGGMIFIIS SIVTVFVITR HPSFETKLAM FAFVGFGIIG LIDDSLKIIH
110 120 130 140 150
KENEGLKAYQ KMLLLLIVSS IIAFYAYNNP KIGSQIIVPF AHITWNLGIF
160 170 180 190 200
YIPFIIFYFA ATTNAVNLTD GLDGLATSIT LLVMTFFAVV SYATGNYTLA
210 220 230 240 250
VFCATVGGAL LGFLKYNAYP AQIFMGDTGS LALGGVVGAV AMMLKLPLIV
260 270 280 290 300
PIVGGIYLAE TLSVIIQVTS FKLTGKRVFK MSPIHHHFEL SGWHETKVVS
310 320
IFSIITVILC LIGFLSLIKM NSLSL
Length:325
Mass (Da):35,444
Last modified:January 7, 2015 - v1
Checksum:iC2F82A9819D1052F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JDRY01000001 Genomic DNA Translation: KGN01888.1
RefSeqiWP_039256884.1, NZ_JDRY01000001.1

Genome annotation databases

EnsemblBacteriaiKGN01888; KGN01888; Z955_00370

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JDRY01000001 Genomic DNA Translation: KGN01888.1
RefSeqiWP_039256884.1, NZ_JDRY01000001.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKGN01888; KGN01888; Z955_00370

Enzyme and pathway databases

UniPathwayi
UPA00219

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0A0ILS0_CLOBO
AccessioniPrimary (citable) accession number: A0A0A0ILS0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: September 27, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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