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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Helicobacter sp. MIT 11-5569
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:2.1.3.15UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:LS70_01650Imported, LS70_09590Imported
OrganismiHelicobacter sp. MIT 11-5569Imported
Taxonomic identifieri1548151 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000029923 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 286CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A099TVM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYLDFEVK IKNIQENIAT AQLKNDAHAI AILQKDLDKE VTKVYSNLSD
60 70 80 90 100
YQKLQLARHP DRPYAMDYIT LLLEEPLEIH GDRHFSDDHA VVCFLGKIDN
110 120 130 140 150
QKVMVIGEEK GRGTKNKLYR NFGMPNPEGY RKALRTAKMA EKFGIPLLMF
160 170 180 190 200
VDTPGAYPGI GAEERGQSEA IAKNLQEFSA LKIPTISIVI GEGGSGGALA
210 220 230 240 250
IGVADRLAMM QYSVFSVISP EGCAAILWND PAKIENATQA LKITPEDLKA
260 270 280 290 300
ANLIDAIIQE PGIGAHRDKE GAAEMIKTYF LESLEAIRKD PDFLNKRFSK

LMNYGSFQA
Length:309
Mass (Da):34,222
Last modified:January 7, 2015 - v1
Checksum:i17CDAF3976D7E211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRPB01000020 Genomic DNA Translation: KGL10345.1
JRPB01000001 Genomic DNA Translation: KGL11480.1
RefSeqiWP_034287361.1, NZ_JRPB01000020.1

Genome annotation databases

EnsemblBacteriaiKGL10345; KGL10345; LS70_09590
KGL11480; KGL11480; LS70_01650

Similar proteinsi

Entry informationi

Entry nameiA0A099TVM3_9HELI
AccessioniPrimary (citable) accession number: A0A099TVM3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 7, 2015
Last sequence update: January 7, 2015
Last modified: July 18, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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