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Entry version 27 (11 Dec 2019)
Sequence version 1 (07 Jan 2015)
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Protein

Autophagy-related protein 11

Gene

ATG11

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy (By similarity). Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32 (By similarity). Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation (By similarity). Required for ATG9 anterograde transport from the mitochondria to the PAS (By similarity). Recruits also the ATG19-prAPE1 complex to the PAS (By similarity). Required for the Cvt vesicles completion (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy-related protein 111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG111 Publication
ORF Names:FG00382, FGRAMPH1_01T01003
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri229533 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000070720 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004439011 – 1429Autophagy-related protein 11Add BLAST1429

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and potential homooligomers (By similarity).

Interacts with ATG1 kinase and the ATG19 and ATG34 cargo protein transporters (By similarity).

Interacts with ATG9, ATG17 and ATG20 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5518.FGSG_00382P0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili540 – 579Sequence analysisAdd BLAST40
Coiled coili616 – 808Sequence analysisAdd BLAST193
Coiled coili842 – 985Sequence analysisAdd BLAST144
Coiled coili1106 – 1135Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG11 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJTT Eukaryota
ENOG410XUEE LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040040 ATG11
IPR019460 Atg11_C

The PANTHER Classification System

More...
PANTHERi
PTHR13222 PTHR13222, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10377 ATG11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A098D065-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQVLIAHT GLRLEVDTAQ FSILDDLKTW VSKKTSIPPQ HIVALNPHGR
60 70 80 90 100
TVKITNLHTE KEIFVYDIRI SSPGNTNLIT PIPLPKRYAV PNAPNTIDDV
110 120 130 140 150
QSITSWQELY KDRRNWAMRL VEDSGQMSSA TLARYSEIDV IIKCLDAAVA
160 170 180 190 200
NLEISIKQIE PKYNDLKKWV APALEEHGNL VERWEQYLDL AKSTPVSPSM
210 220 230 240 250
VKFMTGREIN KARPTLEDLI ELDTAKKAGK LAPTAHRRFS DKANQLGNTA
260 270 280 290 300
SQMYQSLESL IANFETLMSR SALSHSTDSA QLLEDIEAVV KQMDSDYRAA
310 320 330 340 350
LGYGNTQRDV AQASKTASVH TEHLVPTLKK RVKEMEELLH YGTDARNSVA
360 370 380 390 400
SESAKFMRHV TEITSLHSNV KSQINVLNQS EDDMTTFDYL RLIHQLPYMY
410 420 430 440 450
AAFVAEAVRR REWVDKVKTD SSTLANEMAL FQDEESKRRR KWQKMIGSMY
460 470 480 490 500
GPDLDTNVMG LEVNLLGEDT PWPALTKEDL TDFIQILQEQ PVDQTVLDDI
510 520 530 540 550
VKLVQELDSP TKQQSKRLKA FKNGSIHEAA LGRSGLMIRG DDDLLQSLQE
560 570 580 590 600
DKGKLENKLK TAESRVRRLE DLLHRQSQAS RPGNLFQPQG SQQRERVNSA
610 620 630 640 650
SSVRSSRFDD RRRSSEGIDP LMRRITQLEN ELREEKQRSV NLQQELTTQS
660 670 680 690 700
NNHEDVKGQH EDLKAQHEDL KGQMAEINTT KQDLLENMEA LEREFVEERK
710 720 730 740 750
NLEIEIKTLK ARLEDTEDEI EQFDESRQHE KAGLVVRVEE LEAELEQVNK
760 770 780 790 800
QRQDDALKAQ GQVEFLRKET RIQREQQEAL EQQIQSAQEE VQNVSRKLSV
810 820 830 840 850
AEEALDDHWQ ALTRLFSELS PDGTIPDNVV DLSNLLLTQA GTLVEKSRNS
860 870 880 890 900
EADIELLKTQ VEHFSSAISE LREQVSQKDA KLSEDEMTVI HLRENIAEEQ
910 920 930 940 950
AKVSALEQEL ADGREQLTEL RAKLSDGETG PEALQTRLED EEKKVMTLTE
960 970 980 990 1000
EVASKQSHVG SLEEELRMFQ EKVESLQGKI SHMNSHYEHR DEKTKDLTQR
1010 1020 1030 1040 1050
LYSQNDRMCR LLERVGYAVT RKDGEMTVNK IPRAERNAQN LADSTDPSAS
1060 1070 1080 1090 1100
IRKSGTLSRV LGDSVDLELL YWFNNSDMQA EDEKYEEFMN NLGKFDMELF
1110 1120 1130 1140 1150
SETVYRRIKE VEHMARKWQK EARSYRERAH ILQKDSHEKI AFKHFREGDL
1160 1170 1180 1190 1200
ALFLPTRNQQ AGAWAAFNVG FPHYFLREQD AHRLRHREWL VARISRIQER
1210 1220 1230 1240 1250
VVDLSKSLQP SSETESINDE ENDNPFQLSD GLHWYLIDAL EDKPGAPSTP
1260 1270 1280 1290 1300
GMGKSTVAAN TVEATANIHA HGVGGKGKSR ESVTSIEGIN KTLSKSLESR
1310 1320 1330 1340 1350
RSSTNSKKAL PFQLGGTTLL KNSALASETN SLRAHNADTP SGTSPTQGGH
1360 1370 1380 1390 1400
LTSTNASLGQ KNQRVDGPIR QPSDESSTQG GGAKADEQPR SVVQREDSVE
1410 1420
SPTRRSVVWD SLWSVDYNYE SGSRRWLGG
Length:1,429
Mass (Da):162,227
Last modified:January 7, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB43E6FC9CF2E1734
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence SCB64046 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HG970332 Genomic DNA Translation: SCB64046.1 Sequence problems.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG970332 Genomic DNA Translation: SCB64046.1 Sequence problems.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5518.FGSG_00382P0

Phylogenomic databases

eggNOGiENOG410IJTT Eukaryota
ENOG410XUEE LUCA

Family and domain databases

InterProiView protein in InterPro
IPR040040 ATG11
IPR019460 Atg11_C
PANTHERiPTHR13222 PTHR13222, 1 hit
PfamiView protein in Pfam
PF10377 ATG11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG11_GIBZE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A098D065
Secondary accession number(s): A0A0E0RM29, A0A1C3YI63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 25, 2018
Last sequence update: January 7, 2015
Last modified: December 11, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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