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Protein
Submitted name:

Uncharacterized protein

Gene

NOTCH1

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi419Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi422Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi439Calcium 2UniRule annotation1
Metal bindingi440Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi442Calcium 2UniRule annotation1
Metal bindingi456Calcium 2UniRule annotation1
Metal bindingi457Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi477Calcium 3UniRule annotation1
Metal bindingi478Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi480Calcium 3UniRule annotation1
Metal bindingi494Calcium 3UniRule annotation1
Metal bindingi495Calcium 3; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:NOTCH1Imported
OrganismiPapio anubis (Olive baboon)Imported
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 44PROSITE-ProRule annotation
Disulfide bondi76 ↔ 85PROSITE-ProRule annotation
Disulfide bondi116 ↔ 125PROSITE-ProRule annotation
Disulfide bondi153 ↔ 162PROSITE-ProRule annotation
Disulfide bondi193 ↔ 202PROSITE-ProRule annotation
Disulfide bondi232 ↔ 241PROSITE-ProRule annotation
Disulfide bondi270 ↔ 279PROSITE-ProRule annotation
Disulfide bondi310 ↔ 319PROSITE-ProRule annotation
Disulfide bondi348 ↔ 357PROSITE-ProRule annotation
Disulfide bondi368 ↔ 385PROSITE-ProRule annotation
Disulfide bondi387 ↔ 396PROSITE-ProRule annotation
Disulfide bondi403 ↔ 416UniRule annotation
Disulfide bondi410 ↔ 425UniRule annotation
Disulfide bondi427 ↔ 436UniRule annotation
Disulfide bondi443 ↔ 454UniRule annotation
Disulfide bondi448 ↔ 463UniRule annotation
Disulfide bondi465 ↔ 474UniRule annotation
Disulfide bondi481 ↔ 492UniRule annotation
Disulfide bondi486 ↔ 501UniRule annotation
Disulfide bondi503 ↔ 512UniRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi557 ↔ 567PROSITE-ProRule annotation
Disulfide bondi578 ↔ 587PROSITE-ProRule annotation
Disulfide bondi616 ↔ 625PROSITE-ProRule annotation
Disulfide bondi632 ↔ 642PROSITE-ProRule annotation
Disulfide bondi653 ↔ 662PROSITE-ProRule annotation
Disulfide bondi691 ↔ 700PROSITE-ProRule annotation
Disulfide bondi707 ↔ 717PROSITE-ProRule annotation
Disulfide bondi728 ↔ 737PROSITE-ProRule annotation
Disulfide bondi766 ↔ 775PROSITE-ProRule annotation
Disulfide bondi804 ↔ 813PROSITE-ProRule annotation
Disulfide bondi825 ↔ 842PROSITE-ProRule annotation
Disulfide bondi844 ↔ 853PROSITE-ProRule annotation
Disulfide bondi882 ↔ 891PROSITE-ProRule annotation
Disulfide bondi920 ↔ 929PROSITE-ProRule annotation
Disulfide bondi958 ↔ 967PROSITE-ProRule annotation
Disulfide bondi996 ↔ 1005PROSITE-ProRule annotation
Disulfide bondi1034 ↔ 1043PROSITE-ProRule annotation
Disulfide bondi1072 ↔ 1081PROSITE-ProRule annotation
Disulfide bondi1099 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1120 ↔ 1129PROSITE-ProRule annotation
Disulfide bondi1158 ↔ 1167PROSITE-ProRule annotation
Disulfide bondi1196 ↔ 1205PROSITE-ProRule annotation
Disulfide bondi1242 ↔ 1251PROSITE-ProRule annotation
Disulfide bondi1263 ↔ 1280PROSITE-ProRule annotation
Disulfide bondi1282 ↔ 1291PROSITE-ProRule annotation
Disulfide bondi1323 ↔ 1332PROSITE-ProRule annotation
Disulfide bondi1361 ↔ 1370PROSITE-ProRule annotation
Disulfide bondi1384 ↔ 1401PROSITE-ProRule annotation
Disulfide bondi1403 ↔ 1412PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 45EGF-likeInterPro annotationAdd BLAST37
Domaini46 – 86EGF-likeInterPro annotationAdd BLAST41
Domaini89 – 126EGF-likeInterPro annotationAdd BLAST38
Domaini127 – 163EGF-likeInterPro annotationAdd BLAST37
Domaini165 – 203EGF-likeInterPro annotationAdd BLAST39
Domaini205 – 242EGF-likeInterPro annotationAdd BLAST38
Domaini244 – 280EGF-likeInterPro annotationAdd BLAST37
Domaini282 – 320EGF-likeInterPro annotationAdd BLAST39
Domaini322 – 358EGF-likeInterPro annotationAdd BLAST37
Domaini359 – 397EGF-likeInterPro annotationAdd BLAST39
Domaini399 – 437EGF-likeInterPro annotationAdd BLAST39
Domaini439 – 475EGF-likeInterPro annotationAdd BLAST37
Domaini477 – 513EGF-likeInterPro annotationAdd BLAST37
Domaini515 – 551EGF-likeInterPro annotationAdd BLAST37
Domaini553 – 588EGF-likeInterPro annotationAdd BLAST36
Domaini590 – 626EGF-likeInterPro annotationAdd BLAST37
Domaini628 – 663EGF-likeInterPro annotationAdd BLAST36
Domaini665 – 701EGF-likeInterPro annotationAdd BLAST37
Domaini703 – 738EGF-likeInterPro annotationAdd BLAST36
Domaini740 – 776EGF-likeInterPro annotationAdd BLAST37
Domaini778 – 814EGF-likeInterPro annotationAdd BLAST37
Domaini816 – 854EGF-likeInterPro annotationAdd BLAST39
Domaini856 – 892EGF-likeInterPro annotationAdd BLAST37
Domaini894 – 930EGF-likeInterPro annotationAdd BLAST37
Domaini932 – 968EGF-likeInterPro annotationAdd BLAST37
Domaini970 – 1006EGF-likeInterPro annotationAdd BLAST37
Domaini1008 – 1044EGF-likeInterPro annotationAdd BLAST37
Domaini1046 – 1082EGF-likeInterPro annotationAdd BLAST37
Domaini1095 – 1130EGF-likeInterPro annotationAdd BLAST36
Domaini1132 – 1168EGF-likeInterPro annotationAdd BLAST37
Domaini1170 – 1206EGF-likeInterPro annotationAdd BLAST37
Domaini1215 – 1252EGF-likeInterPro annotationAdd BLAST38
Domaini1254 – 1292EGF-likeInterPro annotationAdd BLAST39
Domaini1294 – 1333EGF-likeInterPro annotationAdd BLAST40
Domaini1335 – 1371EGF-likeInterPro annotationAdd BLAST37
Domaini1374 – 1413EGF-likeInterPro annotationAdd BLAST40
Domaini1436 – 1476LNRInterPro annotationAdd BLAST41
Domaini1477 – 1518LNRInterPro annotationAdd BLAST42
Domaini1519 – 1558LNRInterPro annotationAdd BLAST40
Domaini1894 – 2098ANK_REP_REGIONInterPro annotationAdd BLAST205
Repeati1912 – 1944ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1979 – 2011ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2012 – 2044ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2045 – 2077ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00810000125346
OrthoDBiEOG091G01NU

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 35 hits
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A096NRS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LCLPLPPCPR CSQPGETCLN GGKCEVANGT EACVCGGAFV GPRCQDPNPC
60 70 80 90 100
LSTPCKNAGT CHVVDRGGMA DYACSCPLGF SGPLCLTPLD NACLTNPCRN
110 120 130 140 150
GGTCDLLTLT EYKCRCPPGW SGKSCQQADP CASNPCANGG QCLPFEASYI
160 170 180 190 200
CHCPPSFHGP TCRQDVNECG QNPGLCRHGG TCHNEVGSYR CVCRATHTGP
210 220 230 240 250
NCERPYVPCS PSPCQNGGTC RPTGDVTHEC ACLPGFTGQN CEENIDDCPG
260 270 280 290 300
NNCKNGGACV DGVNTYNCRC LPEWTGQYCT EDVDECQLMP NACQNGGTCH
310 320 330 340 350
NTHGGYNCVC VNGWTGEDCS ENIDDCASAA CFHGATCHDR VASFYCECPH
360 370 380 390 400
GRTGLLCHLN DACISNPCNE GSNCDTNPVN GKAICTCPSG YTGPACSQDV
410 420 430 440 450
DECSLGANPC EHAGKCINTL GSFECQCLQG YTGPRCEIDV NECVSNPCQN
460 470 480 490 500
DATCLDQIGE FQCICMPGYE GVHCEVNTDE CASSPCLHNG RCLDKINEFQ
510 520 530 540 550
CECPTGFTGH LCQYDVDECA STPCKNGAKC LDGPNTYTCV CTEGYTGMHC
560 570 580 590 600
EVDIDECDPD PCHYGSCKDG VATFTCLCRP GYTGHHCETN INECSSQPCR
610 620 630 640 650
HGGTCQDRDN AYLCFCLKGT TGPNCEINLD DCASSPCDSG TCLDKIDGYE
660 670 680 690 700
CACEPGYTGS MCNINIDECA GNPCHNGGTC QDGINGFTCR CPEGYHDPTC
710 720 730 740 750
LSEVNECNSN PCVHGACRDS LNGYKCNCDP GWSGTNCDIN NNECESNPCV
760 770 780 790 800
NGGTCKDMTS GYVCTCREGF SGPNCQTNIN ECASNPCLNQ GTCIDDVAGY
810 820 830 840 850
KCNCLLPYTG ATCEVVLAPC APSPCRNGGE CRESEDYESF SCVCPTGWQG
860 870 880 890 900
QTCEVDINEC VVSPCRHGAS CQNTHGGYRC HCQAGYSGRN CETDIDDCRP
910 920 930 940 950
NPCHNGGSCT DGVNTAFCDC LPGFQGTFCE EDINECASDP CRNGANCTDC
960 970 980 990 1000
VDSYTCTCPA GFSGIHCENN TPDCTESSCF NGGTCVDGIN SFTCLCPPGF
1010 1020 1030 1040 1050
TGSYCQHDVN ECDSQPCLHG GTCQDGCGSY RCTCPQGYTG PNCQNLVHWC
1060 1070 1080 1090 1100
DSSPCKNGGK CWQTHTQYRC ECPSGWTGLY CDVPSVSCEV AAQRQGVDVA
1110 1120 1130 1140 1150
RLCQHGGLCV DAGNTHHCRC QAGYTGSYCE DLVDECSPSP CQNGATCTDY
1160 1170 1180 1190 1200
LGGYSCKCVA GYHGVNCSEE IDECLSHPCQ NGGTCLDLPN TYKCSCPRGT
1210 1220 1230 1240 1250
QGVHCEINVD DCNPPVDPVS RSPKCFNNGT CVDQVGGYSC TCPPGFVGER
1260 1270 1280 1290 1300
CEGDVNECLS NPCDARGTQN CVQRVNDFHC ECRAGHTGRR CESVINGCKG
1310 1320 1330 1340 1350
KPCKNGGTCA VASNTARGFI CKCPAGFEGA TCENDARTCG SLRCLNGGTC
1360 1370 1380 1390 1400
ISGPRSPTCL CLGPFTGPEC QFPASSPCLG GNPCYNQGTC EPTSESPFYR
1410 1420 1430 1440 1450
CLCPAKFNGL LCHILDYSFG GGAGRDIPPP QIEEACELPE CQEDAGNKVC
1460 1470 1480 1490 1500
SLQCNNHACG WDGGDCSLNF NDPWKNCTQS LQCWKYFSDG HCDSQCNSAG
1510 1520 1530 1540 1550
CLFDGFDCQR AEGQCNPLYD QYCKDHFSDG HCDQGCNSAE CEWDGLDCAE
1560 1570 1580 1590 1600
HVPERLAAGT LVVVVLMPPE QLRNSSFHFL RELSRVLHTN VVFKRDAHGQ
1610 1620 1630 1640 1650
QMIFPYYGRE EELRKHPIKR AAEGWAAPEA LLGQVKASLL PGGGGGGRRR
1660 1670 1680 1690 1700
RELDPMDVRG SIVYLEIDNR QCVQASSQCF QSATDVAAFL GALASLGSLN
1710 1720 1730 1740 1750
IPYKIEAVQS ETVEPPPPAQ LHFMYVAAAA FVLLFFVGCG VLLSRKRRRQ
1760 1770 1780 1790 1800
HGQLWFPEGF KVSEASKKKR REPLGEDSVG LKPLKNASDG ALMDDNQNEW
1810 1820 1830 1840 1850
GDEDLETKKF RFEEPVVLPD LDDQTDHRQW TQQHLDAADL RMSAMAPTPP
1860 1870 1880 1890 1900
QGEVDADCMD VNVRGRLHPL MIASCSGGGL ETGNSEEEED APAVISDFIY
1910 1920 1930 1940 1950
QGASLHNQTD RTGETALHLA ARYSRSDAAK RLLEASADAN IQDNMGRTPL
1960 1970 1980 1990 2000
HAAVSADAQG VFQILIRNRA TDLDARMHDG TTPLILAARL AVEGMLEDLI
2010 2020 2030 2040 2050
NSHADVNAVD DLGKSALHWA AAVNNVDAAV VLLKNGANKD MQNNKEETPL
2060 2070 2080 2090 2100
FLAAREGSYE TAKVLLDHFA NRDITDHMDR LPRDIAQERM HHDIVRLLDE
2110 2120 2130 2140 2150
YNLVRSPQLH GAPLGGTPTL SPPLCSPNGY LGSLKPGVQG KKVRKPSSKG
2160 2170 2180 2190 2200
LACGSKEAKD LKARRKKSQD GKGCLLDSSG MLSPVDSLES PHGYLSDVAS
2210 2220 2230 2240 2250
PPLLPSPFQQ SPSVPLNHLP GMPDTHLGIG HLNVAAKPEM AALGGGGRLA
2260 2270 2280 2290 2300
FEAGPPRLSH LPVASGTSTV LGCSSGGAMN FTVGGSTSLN GQCEWLSRLQ
2310 2320 2330 2340 2350
SGMVPNQYNP LRGSVAPGPL STQAPSLQHG MVGPLHSSLA ASALSQMMSY
2360 2370 2380 2390 2400
QGLPSTRLAT QPHLVQTQQV QPQNLQMQQQ NLQPPNIQQQ PNLQPPPPPP
2410 2420 2430 2440 2450
QPHLGVSSAA SGHLGRSFLG GEPSQADVQP LGTSSLAVHT ILPQESPALP
2460 2470 2480 2490 2500
TSLPSSLVPP VTAAQFLTPP SQHSYSSSPV DNTPSHQLQV PEHPFLTPSP
2510 2520 2530 2540
ESPDQWSSSS PHSNVSDWSE GVSSPPTSMQ SQIARIPEAF K
Length:2,541
Mass (Da):271,082
Last modified:February 28, 2018 - v2
Checksum:i658323ADE47F080B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3NIB8A0A2I3NIB8_PAPAN
Uncharacterized protein
NOTCH1
2,539Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02007903 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSPANT00000028691; ENSPANP00000015742; ENSPANG00000026129

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02007903 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPANT00000028691; ENSPANP00000015742; ENSPANG00000026129

Phylogenomic databases

GeneTreeiENSGT00810000125346
OrthoDBiEOG091G01NU

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 35 hits
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A096NRS2_PAPAN
AccessioniPrimary (citable) accession number: A0A096NRS2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: February 28, 2018
Last modified: November 7, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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