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Protein
Submitted name:

Notch 1

Gene

NOTCH1

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi419Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi422Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi439Calcium 2UniRule annotation1
Metal bindingi440Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi442Calcium 2UniRule annotation1
Metal bindingi456Calcium 2UniRule annotation1
Metal bindingi457Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi477Calcium 3UniRule annotation1
Metal bindingi478Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi480Calcium 3UniRule annotation1
Metal bindingi494Calcium 3UniRule annotation1
Metal bindingi495Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Notch 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPapio anubis (Olive baboon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000028761 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 44PROSITE-ProRule annotation
Disulfide bondi76 ↔ 85PROSITE-ProRule annotation
Disulfide bondi116 ↔ 125PROSITE-ProRule annotation
Disulfide bondi153 ↔ 162PROSITE-ProRule annotation
Disulfide bondi193 ↔ 202PROSITE-ProRule annotation
Disulfide bondi232 ↔ 241PROSITE-ProRule annotation
Disulfide bondi270 ↔ 279PROSITE-ProRule annotation
Disulfide bondi310 ↔ 319PROSITE-ProRule annotation
Disulfide bondi348 ↔ 357PROSITE-ProRule annotation
Disulfide bondi368 ↔ 385PROSITE-ProRule annotation
Disulfide bondi387 ↔ 396PROSITE-ProRule annotation
Disulfide bondi403 ↔ 416UniRule annotation
Disulfide bondi410 ↔ 425UniRule annotation
Disulfide bondi427 ↔ 436UniRule annotation
Disulfide bondi443 ↔ 454UniRule annotation
Disulfide bondi448 ↔ 463UniRule annotation
Disulfide bondi465 ↔ 474UniRule annotation
Disulfide bondi481 ↔ 492UniRule annotation
Disulfide bondi486 ↔ 501UniRule annotation
Disulfide bondi503 ↔ 512UniRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi557 ↔ 567PROSITE-ProRule annotation
Disulfide bondi578 ↔ 587PROSITE-ProRule annotation
Disulfide bondi616 ↔ 625PROSITE-ProRule annotation
Disulfide bondi632 ↔ 642PROSITE-ProRule annotation
Disulfide bondi653 ↔ 662PROSITE-ProRule annotation
Disulfide bondi691 ↔ 700PROSITE-ProRule annotation
Disulfide bondi707 ↔ 717PROSITE-ProRule annotation
Disulfide bondi728 ↔ 737PROSITE-ProRule annotation
Disulfide bondi766 ↔ 775PROSITE-ProRule annotation
Disulfide bondi804 ↔ 813PROSITE-ProRule annotation
Disulfide bondi825 ↔ 842PROSITE-ProRule annotation
Disulfide bondi844 ↔ 853PROSITE-ProRule annotation
Disulfide bondi882 ↔ 891PROSITE-ProRule annotation
Disulfide bondi920 ↔ 929PROSITE-ProRule annotation
Disulfide bondi958 ↔ 967PROSITE-ProRule annotation
Disulfide bondi996 ↔ 1005PROSITE-ProRule annotation
Disulfide bondi1034 ↔ 1043PROSITE-ProRule annotation
Disulfide bondi1072 ↔ 1081PROSITE-ProRule annotation
Disulfide bondi1099 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1120 ↔ 1129PROSITE-ProRule annotation
Disulfide bondi1158 ↔ 1167PROSITE-ProRule annotation
Disulfide bondi1196 ↔ 1205PROSITE-ProRule annotation
Disulfide bondi1242 ↔ 1251PROSITE-ProRule annotation
Disulfide bondi1263 ↔ 1280PROSITE-ProRule annotation
Disulfide bondi1282 ↔ 1291PROSITE-ProRule annotation
Disulfide bondi1323 ↔ 1332PROSITE-ProRule annotation
Disulfide bondi1361 ↔ 1370PROSITE-ProRule annotation
Disulfide bondi1384 ↔ 1401PROSITE-ProRule annotation
Disulfide bondi1403 ↔ 1412PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 45EGF-likeInterPro annotationAdd BLAST37
Domaini46 – 86EGF-likeInterPro annotationAdd BLAST41
Domaini89 – 126EGF-likeInterPro annotationAdd BLAST38
Domaini127 – 163EGF-likeInterPro annotationAdd BLAST37
Domaini165 – 203EGF-likeInterPro annotationAdd BLAST39
Domaini205 – 242EGF-likeInterPro annotationAdd BLAST38
Domaini244 – 280EGF-likeInterPro annotationAdd BLAST37
Domaini282 – 320EGF-likeInterPro annotationAdd BLAST39
Domaini322 – 358EGF-likeInterPro annotationAdd BLAST37
Domaini359 – 397EGF-likeInterPro annotationAdd BLAST39
Domaini399 – 437EGF-likeInterPro annotationAdd BLAST39
Domaini439 – 475EGF-likeInterPro annotationAdd BLAST37
Domaini477 – 513EGF-likeInterPro annotationAdd BLAST37
Domaini515 – 551EGF-likeInterPro annotationAdd BLAST37
Domaini553 – 588EGF-likeInterPro annotationAdd BLAST36
Domaini590 – 626EGF-likeInterPro annotationAdd BLAST37
Domaini628 – 663EGF-likeInterPro annotationAdd BLAST36
Domaini665 – 701EGF-likeInterPro annotationAdd BLAST37
Domaini703 – 738EGF-likeInterPro annotationAdd BLAST36
Domaini740 – 776EGF-likeInterPro annotationAdd BLAST37
Domaini778 – 814EGF-likeInterPro annotationAdd BLAST37
Domaini816 – 854EGF-likeInterPro annotationAdd BLAST39
Domaini856 – 892EGF-likeInterPro annotationAdd BLAST37
Domaini894 – 930EGF-likeInterPro annotationAdd BLAST37
Domaini932 – 968EGF-likeInterPro annotationAdd BLAST37
Domaini970 – 1006EGF-likeInterPro annotationAdd BLAST37
Domaini1008 – 1044EGF-likeInterPro annotationAdd BLAST37
Domaini1046 – 1082EGF-likeInterPro annotationAdd BLAST37
Domaini1095 – 1130EGF-likeInterPro annotationAdd BLAST36
Domaini1132 – 1168EGF-likeInterPro annotationAdd BLAST37
Domaini1170 – 1206EGF-likeInterPro annotationAdd BLAST37
Domaini1215 – 1252EGF-likeInterPro annotationAdd BLAST38
Domaini1254 – 1292EGF-likeInterPro annotationAdd BLAST39
Domaini1294 – 1333EGF-likeInterPro annotationAdd BLAST40
Domaini1335 – 1371EGF-likeInterPro annotationAdd BLAST37
Domaini1374 – 1413EGF-likeInterPro annotationAdd BLAST40
Domaini1436 – 1476LNRInterPro annotationAdd BLAST41
Domaini1477 – 1518LNRInterPro annotationAdd BLAST42
Domaini1519 – 1558LNRInterPro annotationAdd BLAST40
Domaini1894 – 2098ANK_REP_REGIONInterPro annotationAdd BLAST205
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1912 – 1944ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1979 – 2011ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2012 – 2044ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2045 – 2077ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01984 NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 35 hits
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A096NRS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LCLPLPPCPR CSQPGETCLN GGKCEVANGT EACVCGGAFV GPRCQDPNPC
60 70 80 90 100
LSTPCKNAGT CHVVDRGGMA DYACSCPLGF SGPLCLTPLD NACLTNPCRN
110 120 130 140 150
GGTCDLLTLT EYKCRCPPGW SGKSCQQADP CASNPCANGG QCLPFEASYI
160 170 180 190 200
CHCPPSFHGP TCRQDVNECG QNPGLCRHGG TCHNEVGSYR CVCRATHTGP
210 220 230 240 250
NCERPYVPCS PSPCQNGGTC RPTGDVTHEC ACLPGFTGQN CEENIDDCPG
260 270 280 290 300
NNCKNGGACV DGVNTYNCRC LPEWTGQYCT EDVDECQLMP NACQNGGTCH
310 320 330 340 350
NTHGGYNCVC VNGWTGEDCS ENIDDCASAA CFHGATCHDR VASFYCECPH
360 370 380 390 400
GRTGLLCHLN DACISNPCNE GSNCDTNPVN GKAICTCPSG YTGPACSQDV
410 420 430 440 450
DECSLGANPC EHAGKCINTL GSFECQCLQG YTGPRCEIDV NECVSNPCQN
460 470 480 490 500
DATCLDQIGE FQCICMPGYE GVHCEVNTDE CASSPCLHNG RCLDKINEFQ
510 520 530 540 550
CECPTGFTGH LCQYDVDECA STPCKNGAKC LDGPNTYTCV CTEGYTGMHC
560 570 580 590 600
EVDIDECDPD PCHYGSCKDG VATFTCLCRP GYTGHHCETN INECSSQPCR
610 620 630 640 650
HGGTCQDRDN AYLCFCLKGT TGPNCEINLD DCASSPCDSG TCLDKIDGYE
660 670 680 690 700
CACEPGYTGS MCNINIDECA GNPCHNGGTC QDGINGFTCR CPEGYHDPTC
710 720 730 740 750
LSEVNECNSN PCVHGACRDS LNGYKCNCDP GWSGTNCDIN NNECESNPCV
760 770 780 790 800
NGGTCKDMTS GYVCTCREGF SGPNCQTNIN ECASNPCLNQ GTCIDDVAGY
810 820 830 840 850
KCNCLLPYTG ATCEVVLAPC APSPCRNGGE CRESEDYESF SCVCPTGWQG
860 870 880 890 900
QTCEVDINEC VVSPCRHGAS CQNTHGGYRC HCQAGYSGRN CETDIDDCRP
910 920 930 940 950
NPCHNGGSCT DGVNTAFCDC LPGFQGTFCE EDINECASDP CRNGANCTDC
960 970 980 990 1000
VDSYTCTCPA GFSGIHCENN TPDCTESSCF NGGTCVDGIN SFTCLCPPGF
1010 1020 1030 1040 1050
TGSYCQHDVN ECDSQPCLHG GTCQDGCGSY RCTCPQGYTG PNCQNLVHWC
1060 1070 1080 1090 1100
DSSPCKNGGK CWQTHTQYRC ECPSGWTGLY CDVPSVSCEV AAQRQGVDVA
1110 1120 1130 1140 1150
RLCQHGGLCV DAGNTHHCRC QAGYTGSYCE DLVDECSPSP CQNGATCTDY
1160 1170 1180 1190 1200
LGGYSCKCVA GYHGVNCSEE IDECLSHPCQ NGGTCLDLPN TYKCSCPRGT
1210 1220 1230 1240 1250
QGVHCEINVD DCNPPVDPVS RSPKCFNNGT CVDQVGGYSC TCPPGFVGER
1260 1270 1280 1290 1300
CEGDVNECLS NPCDARGTQN CVQRVNDFHC ECRAGHTGRR CESVINGCKG
1310 1320 1330 1340 1350
KPCKNGGTCA VASNTARGFI CKCPAGFEGA TCENDARTCG SLRCLNGGTC
1360 1370 1380 1390 1400
ISGPRSPTCL CLGPFTGPEC QFPASSPCLG GNPCYNQGTC EPTSESPFYR
1410 1420 1430 1440 1450
CLCPAKFNGL LCHILDYSFG GGAGRDIPPP QIEEACELPE CQEDAGNKVC
1460 1470 1480 1490 1500
SLQCNNHACG WDGGDCSLNF NDPWKNCTQS LQCWKYFSDG HCDSQCNSAG
1510 1520 1530 1540 1550
CLFDGFDCQR AEGQCNPLYD QYCKDHFSDG HCDQGCNSAE CEWDGLDCAE
1560 1570 1580 1590 1600
HVPERLAAGT LVVVVLMPPE QLRNSSFHFL RELSRVLHTN VVFKRDAHGQ
1610 1620 1630 1640 1650
QMIFPYYGRE EELRKHPIKR AAEGWAAPEA LLGQVKASLL PGGGGGGRRR
1660 1670 1680 1690 1700
RELDPMDVRG SIVYLEIDNR QCVQASSQCF QSATDVAAFL GALASLGSLN
1710 1720 1730 1740 1750
IPYKIEAVQS ETVEPPPPAQ LHFMYVAAAA FVLLFFVGCG VLLSRKRRRQ
1760 1770 1780 1790 1800
HGQLWFPEGF KVSEASKKKR REPLGEDSVG LKPLKNASDG ALMDDNQNEW
1810 1820 1830 1840 1850
GDEDLETKKF RFEEPVVLPD LDDQTDHRQW TQQHLDAADL RMSAMAPTPP
1860 1870 1880 1890 1900
QGEVDADCMD VNVRGRLHPL MIASCSGGGL ETGNSEEEED APAVISDFIY
1910 1920 1930 1940 1950
QGASLHNQTD RTGETALHLA ARYSRSDAAK RLLEASADAN IQDNMGRTPL
1960 1970 1980 1990 2000
HAAVSADAQG VFQILIRNRA TDLDARMHDG TTPLILAARL AVEGMLEDLI
2010 2020 2030 2040 2050
NSHADVNAVD DLGKSALHWA AAVNNVDAAV VLLKNGANKD MQNNKEETPL
2060 2070 2080 2090 2100
FLAAREGSYE TAKVLLDHFA NRDITDHMDR LPRDIAQERM HHDIVRLLDE
2110 2120 2130 2140 2150
YNLVRSPQLH GAPLGGTPTL SPPLCSPNGY LGSLKPGVQG KKVRKPSSKG
2160 2170 2180 2190 2200
LACGSKEAKD LKARRKKSQD GKGCLLDSSG MLSPVDSLES PHGYLSDVAS
2210 2220 2230 2240 2250
PPLLPSPFQQ SPSVPLNHLP GMPDTHLGIG HLNVAAKPEM AALGGGGRLA
2260 2270 2280 2290 2300
FEAGPPRLSH LPVASGTSTV LGCSSGGAMN FTVGGSTSLN GQCEWLSRLQ
2310 2320 2330 2340 2350
SGMVPNQYNP LRGSVAPGPL STQAPSLQHG MVGPLHSSLA ASALSQMMSY
2360 2370 2380 2390 2400
QGLPSTRLAT QPHLVQTQQV QPQNLQMQQQ NLQPPNIQQQ PNLQPPPPPP
2410 2420 2430 2440 2450
QPHLGVSSAA SGHLGRSFLG GEPSQADVQP LGTSSLAVHT ILPQESPALP
2460 2470 2480 2490 2500
TSLPSSLVPP VTAAQFLTPP SQHSYSSSPV DNTPSHQLQV PEHPFLTPSP
2510 2520 2530 2540
ESPDQWSSSS PHSNVSDWSE GVSSPPTSMQ SQIARIPEAF K
Length:2,541
Mass (Da):271,082
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i658323ADE47F080B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3NIB8A0A2I3NIB8_PAPAN
Notch 1
NOTCH1
2,539Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AHZZ02007903 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPANT00000028691; ENSPANP00000015742; ENSPANG00000026129

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02007903 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPANT00000028691; ENSPANP00000015742; ENSPANG00000026129

Phylogenomic databases

GeneTreeiENSGT00940000157157

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 35 hits
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A096NRS2_PAPAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A096NRS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 41 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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