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Protein
Submitted name:

Rho guanine nucleotide exchange factor 40

Gene

ARHGEF40

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 40Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF40Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPapio anubis (Olive baboon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000028761 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1084 – 1252DHInterPro annotationAdd BLAST169
Domaini1264 – 1371PHInterPro annotationAdd BLAST108

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161599

Database of Orthologous Groups

More...
OrthoDBi
578732at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A096NNN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD
60 70 80 90 100
FLVPAKHLLA KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL
110 120 130 140 150
RPGDFYLQVV PSAAQAPRLA LKCLAPGGGR VQEIPVPNEA CAYLFTPEWL
160 170 180 190 200
QGINKDRPTG RLSTCLLSAP SGIQRLPWAE LICPRFVHKE GLMVGHQPST
210 220 230 240 250
LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG EYVELLEVTL
260 270 280 290 300
PVRGSPADAE GSPGPSRVRT VPTRKGAGGK GRHRRHRAWV HQKGLGPRDQ
310 320 330 340 350
DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASESCPL
360 370 380 390 400
RPGELRGGGG GQGAEGPPGT PRRTGKGNRR KKRAAGRGAL SRGGDSAPLS
410 420 430 440 450
PGDKEEASHQ EALGNLPSPS EHKLPECSLV KEEYEGSGKP DSEPKEFKTA
460 470 480 490 500
GEKEPQPSEA CGPTEEGARE REQEGPGLVC MAGHAGPEGL LSDTPTPLLE
510 520 530 540 550
TVQEGKADSI PEEALPVSIS DDPDVAWDLM ASGFFILTGG VDQSGRALLT
560 570 580 590 600
ITPPCPPEEP PPSRDMLNTT LHYLHSLLRP DLQTLGLSVL LDLRQAPSLP
610 620 630 640 650
PALITVLSQL QDSGDPPLVQ RLLILTHDDL PSELCGFQGA EVLSENDLKR
660 670 680 690 700
VTAPEELQWE LGGHRDPSPS HWVEIHQEVV RLCRLCQGVL GSVRQAIEEL
710 720 730 740 750
EGAAEPEEEE AVGMPKPLQK VLADPRLTAL QRDGGAILMR LRSTHSSKLE
760 770 780 790 800
GQGPATLYQE VDEAIHQLVR LSNLHVQHQE QRQCLRRLQQ VLQWLSGPGE
810 820 830 840 850
EQLASFAVPG DTLSALQETE LRFRAFSAEV QERLAQAREA LALEENATSQ
860 870 880 890 900
KVLDIFEQRL EQVESGLHRA LRLQRFFQQA HEWVDEGFAR LAGAGPGREA
910 920 930 940 950
VLAALALRRA PEPSAGTFQE MRALALDLGN PAALREWGRC RARCQELERR
960 970 980 990 1000
IQQHLGEEAS PRGYRRRRAD SASSGGAQWG PHSPSPSLSS LLLPSSPGPR
1010 1020 1030 1040 1050
AAPSHCSLAP CGEDYEEEGP ELAPEAEGRP PRAVLIRGLE VTSTEVVDRT
1060 1070 1080 1090 1100
CSPREHVLLG RAAGPDGPWG VGTPRMERKR SISAQQRLVS ELIACEQDYV
1110 1120 1130 1140 1150
ATLSEPVPPP GPELTPELRG TWAAALSARE RLRSFHRTHF LRELQGCATH
1160 1170 1180 1190 1200
PLRIGACFLR HGDQFSLYAQ YVKHRHKLEN GLAVLSPSSK GSMEAGPYLP
1210 1220 1230 1240 1250
RALQQPLEQL ARYGRLLEEL LREAGPELSS ERQALGAAVQ LLREQEARGR
1260 1270 1280 1290 1300
DLLAVEAVRG CEIDLKEQGQ LLHRDPFTVI CGRKKCLRHV FLFEHLLLFS
1310 1320 1330 1340 1350
KLKGPEGGSE MFVYKQAFKT ADMGLTENIG DSGLCFELWF RRRRAREAYT
1360 1370 1380 1390 1400
LQATSPEIKL KWTSSIAQLL WRQAAHNKEL RVQQMVSMGI GNKPFLDIKA
1410 1420 1430 1440 1450
LGERTLSALL TGRAARTRAS VAVSSFEHAG PSLPGLSPGA CSLPARVEEE
1460 1470 1480 1490 1500
AWDLDVKQIS LAPETLDSSG DVSPGPRNSP SLQPPNPGSS TPTLASRGIL
1510
GLSRQSHARA LSDPTTPL
Length:1,518
Mass (Da):164,734
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BA37137C7ADA8B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3NGA0A0A2I3NGA0_PAPAN
Rho guanine nucleotide exchange fac...
ARHGEF40
1,519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3MQL2A0A2I3MQL2_PAPAN
Rho guanine nucleotide exchange fac...
ARHGEF40
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AHZZ02031733 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_003901559.1, XM_003901510.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPANT00000015668; ENSPANP00000014598; ENSPANG00000000451

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101014767

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02031733 Genomic DNA No translation available.
RefSeqiXP_003901559.1, XM_003901510.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPANT00000015668; ENSPANP00000014598; ENSPANG00000000451
GeneIDi101014767

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55701

Phylogenomic databases

GeneTreeiENSGT00940000161599
OrthoDBi578732at2759

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A096NNN8_PAPAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A096NNN8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 31 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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