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Entry version 32 (12 Aug 2020)
Sequence version 2 (28 Feb 2018)
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Protein

Fanconi_A_N domain-containing protein

Gene

FANCA

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi_A_N domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FANCAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPapio anubis (Olive baboon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000028761 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A096NB00, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9555.ENSPANP00000009906

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 512Fanconi_A_NInterPro annotationAdd BLAST353

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT8N, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007852

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005268_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003516, FANCA
IPR031729, Fanconi_A_N

The PANTHER Classification System

More...
PANTHERi
PTHR12047, PTHR12047, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03511, Fanconi_A, 1 hit
PF15865, Fanconi_A_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00826, FANCONIAGENE

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A096NB00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLRVPNSA SGQGLGGHRR SWAELLAGRL KRQKYNPERA QKLKDSAVRL
60 70 80 90 100
LRSHQDLTAL LLEVEGPPCK KLSLSKLIDC DSSEACANHS SSFIGNSALQ
110 120 130 140 150
DQASRLGVPV GVLSAGMVAS SVGQVCTAAA ETKKLSSLLE FAQYLLAHSM
160 170 180 190 200
FSRLSFCQEL WKIQNSLLLE VVWHLHVQGI VSLEELLESH PDMRAVGAWL
210 220 230 240 250
FRNLCCLCEQ IEASCQHADV ARAMLSDFVQ MFVLRGFQKN SDLRRTVEPE
260 270 280 290 300
KMPQVAVDVL QRMLIFALDA LAAGVQEESS THKTVRCWFG VFSGHMLGGV
310 320 330 340 350
ISTASPKRFF SHTLTQILTH SPLLKASDAV QMQREWSFAR THPLLTALYR
360 370 380 390 400
RLFVMLSPEE LVGHLQEVLE TQEVHWQRVL SFVSALVVCF PEAQQLLEDW
410 420 430 440 450
VARLMAQAFE SCQLDSMVTA FLVVRQAALE GPSVFQSYAD WFKASFGSTR
460 470 480 490 500
GYHGCSKKAL VFLFTFLSDL VPFESPWYLQ VHILHPPLVP SKYRSLLTDY
510 520 530 540 550
ISLAKTRLAD LKVSIESMGL YEDLSSAGDI TEPHSQALQD VEKAVMVFEH
560 570 580 590 600
TGKIPVTVME ASIFRRPYYV SHFLPALLTP RVLPKVPDSR VAFIESLKRA
610 620 630 640 650
DKIPPSLYST YCQACSAAEE KPEDAALGVR AEPSSAEEPL EQLTAALGEL
660 670 680 690 700
RASMTDPSQS DVISAQVAVI SERLRAALGH NEDDSSTEIS KIQLSINAPR
710 720 730 740 750
LEPREYTAVD LLLTSFCQNL MAASSVAPPE RQGPWATLFM RTMCGRVLPA
760 770 780 790 800
VLTRLCQLLH HQGPSLSAPH VLGLAALAVH LGESRSALPE VDVGPPAPDA
810 820 830 840 850
GLPVPALFDS LLTCRTRDSL LFCLKFCTAA ISYSLCKFSS QSRDILRSCL
860 870 880 890 900
SPGLIKKFQF LVFRLFSEAR QPLSQEDAAS LSWRPLYLPS ADWQRAALSL
910 920 930 940 950
WTHRTFRELL KEEDVHLTYQ DWLHLELEIK PEADALSDTE RQDFHQWAIY
960 970 980 990 1000
EHFLPKSSAS GGCDGDLEAA CTILVNALMD FHQSSRSYDH SENSDLVFGG
1010 1020 1030 1040 1050
RTGNEDIISR LQEMVADLEL QQDPSVPLGH TPSQGHFLFG IFGRRLQALT
1060 1070 1080 1090 1100
SGWNVAASLQ RQRELLMYKR ILLRLPSSVL CGSSFQAEQP ITARCKQFFH
1110 1120 1130 1140 1150
LVNSEMRNFC SHGGALTQDI TAHFFRGLLN ACLRSRDPSL MVDFILAKCQ
1160 1170 1180 1190 1200
TKCPLILTSA LLWWPSLEPV LLCQWRRHCQ SPLPRELQKL QEGRQFASDF
1210 1220 1230 1240 1250
LSPDAASPAP NPAWLSAAAL HFAIQQVREE NVRKQLTKLD CEREELLVFL
1260 1270 1280 1290 1300
FFFSLMGLLS SHLTSNSATD PSKALDVCAA VLECLEKRKI SWLALFQLTE
1310 1320 1330 1340 1350
SDLRLGRLLL RVAPDQHTRL LPFTFYSLLS YFHDDAAIRE EAFLHVAVDM
1360 1370 1380 1390 1400
YLRLVQLFVA GDTSTVSPSA SRSLELQGQG NPVELITKAR LFLLQLIPRC
1410 1420 1430 1440
PKKSFSHIAE LLADRGDCDP EVSTALRSRQ QAAPDADLYQ EPHLF
Length:1,445
Mass (Da):161,157
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i298CE8CE260C5359
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3M026A0A2I3M026_PAPAN
Fanconi_A_N domain-containing prote...
FANCA
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3MPY5A0A2I3MPY5_PAPAN
Fanconi_A_N domain-containing prote...
FANCA
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AHZZ02019247 Genomic DNA No translation available.
AHZZ02019248 Genomic DNA No translation available.
AHZZ02019249 Genomic DNA No translation available.
AHZZ02019250 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPANT00000024279; ENSPANP00000009906; ENSPANG00000008150

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHZZ02019247 Genomic DNA No translation available.
AHZZ02019248 Genomic DNA No translation available.
AHZZ02019249 Genomic DNA No translation available.
AHZZ02019250 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9555.ENSPANP00000009906

Genome annotation databases

EnsembliENSPANT00000024279; ENSPANP00000009906; ENSPANG00000008150

Phylogenomic databases

eggNOGiENOG502QT8N, Eukaryota
GeneTreeiENSGT00390000007852
HOGENOMiCLU_005268_0_0_1

Gene expression databases

ExpressionAtlasiA0A096NB00, baseline

Family and domain databases

InterProiView protein in InterPro
IPR003516, FANCA
IPR031729, Fanconi_A_N
PANTHERiPTHR12047, PTHR12047, 1 hit
PfamiView protein in Pfam
PF03511, Fanconi_A, 1 hit
PF15865, Fanconi_A_N, 1 hit
PRINTSiPR00826, FANCONIAGENE

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A096NB00_PAPAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A096NB00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 32 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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