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Protein
Submitted name:

DNA polymerase alpha catalytic subunit

Gene

Pola1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-RNO-174411 Polymerase switching on the C-strand of the telomere
R-RNO-174430 Telomere C-strand synthesis initiation
R-RNO-68952 DNA replication initiation
R-RNO-68962 Activation of the pre-replicative complex
R-RNO-69091 Polymerase switching
R-RNO-69166 Removal of the Flap Intermediate
R-RNO-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Submitted name:
DNA polymerase alpha catalytic subunitImported
Gene namesi
Name:Pola1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621816 Pola1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSRNOG00000013322
ExpressionAtlasiA0A096MJL5 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 102DNA_pol_alpha_NInterPro annotationAdd BLAST62
Domaini378 – 462DNA_pol_B_exo1InterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiKOG0970 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00550000074891

Family and domain databases

InterProiView protein in InterPro
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR024647 DNA_pol_a_cat_su_N
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
PANTHERiPTHR10322:SF26 PTHR10322:SF26, 1 hit
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A096MJL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVHGDDCK LETSDVSGSG SFVASRARRE KKSKKGRQEA LERLKKAKAG
60 70 80 90 100
EKYKYEVEDL TSVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI
110 120 130 140 150
FDDDLEDDAL DTCGEGSDGK AHRKDRKDVK KPSVTKPNNI KAMFIASAGK
160 170 180 190 200
KTTDKTVDLS KDDLLGDILQ DLNTETPQIA PPPVLIPKKK RSTGALPNPF
210 220 230 240 250
SVDTPKAIPS GKPASLVLRN KPLLTPIPLK HAEFAGELAQ PECPEDEQES
260 270 280 290 300
GVIEFEDGDF DEPMDTEEVD EEEPVTAKIW DQESEPVEGV KHEADPETGT
310 320 330 340 350
TSFLDSFLPD VSCWDIDQKD ENSFLLQEVQ VDSNHLPLVK GADDEQVFQF
360 370 380 390 400
YWLDAYEDAY NQPGVVFLFG KVWVESAKTH VSCCVMVKNI ERTLYFLPRE
410 420 430 440 450
MKIDLNTGKE TATPITMKDV YEEFDSKISA KYKIMKFKSK IVEKNYAFEI
460
PDVPEKSEYL EVRYS
Length:465
Mass (Da):52,408
Last modified:November 26, 2014 - v1
Checksum:i7E57AD05D466C759
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei465Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07038842 Genomic DNA No translation available.
AABR07038843 Genomic DNA No translation available.
AABR07038844 Genomic DNA No translation available.
AABR07038845 Genomic DNA No translation available.
AABR07038846 Genomic DNA No translation available.
AABR07038847 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000076359; ENSRNOP00000068175; ENSRNOG00000013322

Entry informationi

Entry nameiA0A096MJL5_RAT
AccessioniPrimary (citable) accession number: A0A096MJL5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: July 18, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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