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Entry version 27 (08 May 2019)
Sequence version 1 (26 Nov 2014)
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Protein

Coiled-coil domain-containing protein 187

Gene

CCDC187

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 187Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC187Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30942 CCDC187

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0A096LP49

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000260220

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC187

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004353961 – 1063Coiled-coil domain-containing protein 187Add BLAST1063

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A096LP49

PRoteomics IDEntifications database

More...
PRIDEi
A0A096LP49

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0A096LP49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0A096LP49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000260220 Expressed in 49 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A096LP49 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A0A096LP49, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A096LP49

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili816 – 851Sequence analysisAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000065015

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWTACED

Database of Orthologous Groups

More...
OrthoDBi
806866at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028750 CEP350

The PANTHER Classification System

More...
PANTHERi
PTHR13958 PTHR13958, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A0A096LP49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTLVVGTPP TCLGDTPQPC HKNSQRQGPF SHGAPGRAAD WKAVAKPRLC
60 70 80 90 100
APAAEDDVAA LRWPGPSQQP DPPWAAPHVV GSDDLKEPGP WGKACSLPMW
110 120 130 140 150
STGPEARDGD SSVSSGRLSC SSGGHDVCVS WKERPPQVLG PQQRPRKSDA
160 170 180 190 200
RLEQLRDKIR AQAWQQGSCA SLGTSAPSSA SRLHKASTLM LRRKGQEAKN
210 220 230 240 250
PPPAPECSGF SILSAAERRV EAKASHGQGR ELSRVSQHQV PVLREKPKRV
260 270 280 290 300
KSSSCKREKT PKLPSPRRAA KDKHKDEDSE LVGVYAWRKG QALVRSLLGP
310 320 330 340 350
PPVLRRHHSK DPSRDPALTV DLGDSEKVIA AKCSPVCAQL PDATSAYSDQ
360 370 380 390 400
QVSGNTPSLA SFDQPATIQT AMAILQDLRQ QIQAGLELAQ ARKGGQELGP
410 420 430 440 450
SKRRLQDVAG RGCCRDPNAQ SSFSKSPWAM TERKHSSLER ARSVHTWEPW
460 470 480 490 500
SSSTARESCP QRAWGAQGQD RSFQRPESPH ERLGHFSQRP WSALAGQACS
510 520 530 540 550
PQRAWGAQRQ GPSSQRPGSP PEKRSPFPQQ PWSAVATQPC PRRAWTACET
560 570 580 590 600
WEDPGPRLRN PLERPSPPAQ RPWSSSGVQR AGPQGKGRGI GSPVSAAKHA
610 620 630 640 650
LPRPTGSFPQ NPLGKEKDTL RPCPRSRGLL GPSHSSESLR EFMRQKAQAR
660 670 680 690 700
RRQALEEKAS ALRTRELRSR RLQEVYRQQR EAVLGRAVPV VSRTTPGIVT
710 720 730 740 750
FVPSSAQSGG LEASGSLESP VLEWSKVTSG MVLGGQEAPG SFCLCLNRAW
760 770 780 790 800
NHAETLDPPG MGGPQDGRDA PVLLSASPSL GSLELQDLTT RYLPRGMCIY
810 820 830 840 850
LDPKEAEHLG TSSSLHLRHK QAQLQALETT AKVLKQRVDS LTAKLQGAEA
860 870 880 890 900
LDTVRDPAVG LLRSCPHSLP AAPTLATPTL ATPACPGALG PNWGRGAPGE
910 920 930 940 950
WVSMQPQPLL PPTYFLDGET LSWGPSWEQQ QSVSPRAHCE SKPRGFPEEG
960 970 980 990 1000
HVDVKPDKRL QRGVAPFQAL SPSAGSSYAG PATLHPIWGS LGLEETPSVG
1010 1020 1030 1040 1050
GADSVAPCTP RSCGKGDPAD RPWAGWSGGR GIHREHLPLP STRAWPYGVE
1060
KSFSTWRAST PRY
Length:1,063
Mass (Da):114,856
Last modified:November 26, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E9464F37B352991
GO
Isoform 2 (identifier: A0A096LP49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Show »
Length:965
Mass (Da):104,626
Checksum:iDBE4CD2F7B83A5AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B733A0A075B733_HUMAN
Coiled-coil domain-containing prote...
CCDC187
965Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B739A0A075B739_HUMAN
Coiled-coil domain-containing prote...
CCDC187
953Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQX5A0A1W2PQX5_HUMAN
Coiled-coil domain-containing prote...
CCDC187
2,077Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31926 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190M → T in AAH31926 (PubMed:15489334).Curated1
Sequence conflicti347Y → H in AAH31926 (PubMed:15489334).Curated1
Sequence conflicti413C → R in AAH31926 (PubMed:15489334).Curated1
Sequence conflicti851L → P in AAH31926 (PubMed:15489334).Curated1
Sequence conflicti917D → E in AAH31926 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0580661 – 98Missing in isoform 2. Add BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP326719 Genomic DNA No translation available.
BC031926 mRNA Translation: AAH31926.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS78462.1 [A0A096LP49-2]

NCBI Reference Sequences

More...
RefSeqi
XP_011516985.1, XM_011518683.2 [A0A096LP49-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000569961; ENSP00000456543; ENSG00000260220 [A0A096LP49-2]
ENST00000624277; ENSP00000485393; ENSG00000260220 [A0A096LP49-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
399693

UCSC genome browser

More...
UCSCi
uc064xbe.1 human [A0A096LP49-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP326719 Genomic DNA No translation available.
BC031926 mRNA Translation: AAH31926.1 Different initiation.
CCDSiCCDS78462.1 [A0A096LP49-2]
RefSeqiXP_011516985.1, XM_011518683.2 [A0A096LP49-1]

3D structure databases

SMRiA0A096LP49
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA0A096LP49, 1 interactor

PTM databases

iPTMnetiA0A096LP49
PhosphoSitePlusiA0A096LP49

Polymorphism and mutation databases

BioMutaiCCDC187

Proteomic databases

jPOSTiA0A096LP49
PRIDEiA0A096LP49

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569961; ENSP00000456543; ENSG00000260220 [A0A096LP49-2]
ENST00000624277; ENSP00000485393; ENSG00000260220 [A0A096LP49-1]
GeneIDi399693
UCSCiuc064xbe.1 human [A0A096LP49-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
399693

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC187
HGNCiHGNC:30942 CCDC187
neXtProtiNX_A0A096LP49
OpenTargetsiENSG00000260220

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00530000065015
OMAiAWTACED
OrthoDBi806866at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
399693

Protein Ontology

More...
PROi
PR:A0A096LP49

Gene expression databases

BgeeiENSG00000260220 Expressed in 49 organ(s), highest expression level in right uterine tube
ExpressionAtlasiA0A096LP49 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028750 CEP350
PANTHERiPTHR13958 PTHR13958, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC187_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A096LP49
Secondary accession number(s): Q8N5P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: November 26, 2014
Last modified: May 8, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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