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Protein
Submitted name:

Cyclin-dependent kinase-like 5

Gene

CDKL5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin-dependent kinase-like 5Imported
Gene namesi
Name:CDKL5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000008086.10
HGNCiHGNC:11411 CDKL5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000008086

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A096LP32

Expressioni

Gene expression databases

BgeeiENSG00000008086 Expressed in 195 organ(s), highest expression level in dorsolateral prefrontal cortex
ExpressionAtlasiA0A096LP32 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A096LP32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 68Protein kinaseInterPro annotationAdd BLAST56

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A096LP32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN
60
EEVKETTLRE LKMLRTLK
Length:68
Mass (Da):7,814
Last modified:November 26, 2014 - v1
Checksum:i1407024FA4CF111E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O76039CDKL5_HUMAN
Cyclin-dependent kinase-like 5
CDKL5 STK9
1,030Annotation score:
A0A096LNR9A0A096LNR9_HUMAN
Cyclin-dependent kinase-like 5
CDKL5
784Annotation score:
A0A1B0GUM4A0A1B0GUM4_HUMAN
Cyclin-dependent kinase-like 5
CDKL5
881Annotation score:
A0A1B0GTX4A0A1B0GTX4_HUMAN
Cyclin-dependent kinase-like 5
CDKL5
471Annotation score:
A0A096LPG3A0A096LPG3_HUMAN
Cyclin-dependent kinase-like 5
CDKL5
60Annotation score:
A0A096LPI4A0A096LPI4_HUMAN
Cyclin-dependent kinase-like 5
CDKL5
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei68Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109798 Genomic DNA No translation available.
Z92542 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000624700; ENSP00000485359; ENSG00000008086
UCSCiuc064yfg.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109798 Genomic DNA No translation available.
Z92542 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A096LP32
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A096LP32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624700; ENSP00000485359; ENSG00000008086
UCSCiuc064yfg.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000008086.10
HGNCiHGNC:11411 CDKL5
OpenTargetsiENSG00000008086
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262

Miscellaneous databases

ChiTaRSiCDKL5 human

Gene expression databases

BgeeiENSG00000008086 Expressed in 195 organ(s), highest expression level in dorsolateral prefrontal cortex
ExpressionAtlasiA0A096LP32 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A096LP32_HUMAN
AccessioniPrimary (citable) accession number: A0A096LP32
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: September 12, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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