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Protein

Lactoylglutathione lyase

Gene

Y956_09366

Organism
Nipponia nippon (Crested ibis) (Ibis nippon)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.UniRule annotation

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.UniRule annotation

Cofactori

Zn2+UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 1 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Lactoylglutathione lyase (Y956_09366)
  2. no protein annotated in this organism
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationImported
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00619;UER00675

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoylglutathione lyaseUniRule annotation (EC:4.4.1.5UniRule annotation)
Alternative name(s):
Glyoxalase IUniRule annotation
Gene namesi
ORF Names:Y956_09366Imported
OrganismiNipponia nippon (Crested ibis) (Ibis nippon)Imported
Taxonomic identifieri128390 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePelecaniformesThreskiornithidaeNipponia
Proteomesi
  • UP000053283 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 179VOCInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the glyoxalase I family.UniRule annotation

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR004361 Glyoxalase_1
IPR018146 Glyoxalase_1_CS
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR00068 glyox_I, 1 hit
PROSITEiView protein in PROSITE
PS00934 GLYOXALASE_I_1, 1 hit
PS00935 GLYOXALASE_I_2, 1 hit
PS51819 VOC, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A091W045-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SPDMAAPAEL SGLSDEAAYG ACSEPDASTK DFLLQQTMLR VKDPKKSLDF
60 70 80 90 100
YTRVLGMTLL QKFDFPTMKF SLYFLAYEDK NNIPKDKTER TAWTFSRKAT
110 120 130 140 150
LELTHNWGTE NDENQSYHNG NSDPRGFGHI GIAVPDVNKA CKRFEELGVK
160 170 180
FVKKPDDGKM KGLAFVQDPD GYWIEILNPN HMVTLT
Length:186
Mass (Da):21,021
Last modified:November 26, 2014 - v1
Checksum:i82435EB240CC7345
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei186Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL411537 Genomic DNA Translation: KFR08804.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KL411537 Genomic DNA Translation: KFR08804.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00619;UER00675

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR004361 Glyoxalase_1
IPR018146 Glyoxalase_1_CS
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR00068 glyox_I, 1 hit
PROSITEiView protein in PROSITE
PS00934 GLYOXALASE_I_1, 1 hit
PS00935 GLYOXALASE_I_2, 1 hit
PS51819 VOC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A091W045_NIPNI
AccessioniPrimary (citable) accession number: A0A091W045
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: December 20, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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