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Entry version 28 (02 Jun 2021)
Sequence version 1 (26 Nov 2014)
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Protein

von Willebrand factor

Gene

Z169_06954

Organism
Egretta garzetta (Little egret)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulationARBA annotation, Hemostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factorARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Z169_06954Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEgretta garzetta (Little egret)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri188379 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePelecaniformesArdeidaeEgretta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000053119 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500187705523 – 2805von Willebrand factorSequence analysisAdd BLAST2783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2716 ↔ 2766PROSITE-ProRule annotation
Disulfide bondi2731 ↔ 2780PROSITE-ProRule annotation
Disulfide bondi2742 ↔ 2796PROSITE-ProRule annotation
Disulfide bondi2746 ↔ 2798PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residuesARBA annotation, Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 238VWFDInterPro annotationAdd BLAST207
Domaini385 – 596VWFDInterPro annotationAdd BLAST212
Domaini864 – 1063VWFDInterPro annotationAdd BLAST200
Domaini1269 – 1445VWFAInterPro annotationAdd BLAST177
Domaini1490 – 1670VWFAInterPro annotationAdd BLAST181
Domaini1679 – 1860VWFAInterPro annotationAdd BLAST182
Domaini1938 – 2142VWFDInterPro annotationAdd BLAST205
Domaini2246 – 2319VWFCInterPro annotationAdd BLAST74
Domaini2420 – 2486VWFCInterPro annotationAdd BLAST67
Domaini2572 – 2637VWFCInterPro annotationAdd BLAST66
Domaini2716 – 2804CTCKInterPro annotationAdd BLAST89

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207, Cys_knot_C
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR037578, Von_Willebrand_factor
IPR002035, VWF_A
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF361, PTHR11339:SF361, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742, C8, 4 hits
PF01826, TIL, 4 hits
PF00092, VWA, 3 hits
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00327, VWA, 3 hits
SM00214, VWC, 5 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 3 hits
SSF57567, SSF57567, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS50234, VWFA, 3 hits
PS01208, VWFC_1, 3 hits
PS50184, VWFC_2, 3 hits
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A091JQY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFLAVLLTN LLLASVISGS SGSLLPESSV SRCSLFGNDH IKTFDGSFYY
60 70 80 90 100
FAGDCSYLLA GDCHKHSFSL LGDYQDGEKI GFSVYLGEYF NLRFSLDGHV
110 120 130 140 150
MQEDKRVSIP FASNGVFIEK ETGYYKISSD EHGFVVKIDI SGNIQILLQE
160 170 180 190 200
KHYNRTCGLC GNFNKFAEDD FRTQEGTLVG NSYDFANSWA LHSENKRCKR
210 220 230 240 250
VQTPSNTCNI SADTAEKGVM ETCQLLRTSL TFSRCHHRVD PEPYINHCER
260 270 280 290 300
DICACIQGVD CHCTVFLDYA RSCAHEGVIL DGWPEESSCR PRCPVGMEYK
310 320 330 340 350
ECVSPCAKTC QSLNINEVCH GQCVDGCSCP EGKLLDGEHC IESSDCSCIH
360 370 380 390 400
SGKHYPPGFT ISQDCNSCIC RHGTWICSNG ECPGECSVTG QSHFKSFDNK
410 420 430 440 450
YFTFSGICQY LFAKDCVENS FSVIIETVQC ADDPDAVCTR SASVRIRDMD
460 470 480 490 500
NSLIKMKHGG GILLNGQDIQ IPLLQGALRI QRTVRTSVRL TYGEDLQIDW
510 520 530 540 550
DGHGELLLKL SPVYSERMCG LCGNYNGNQG DDFLTPSGMV EALLEDFGNS
560 570 580 590 600
WKLNADCQDL LKQDSDPCNL NPRLAKYAED SCSVLMSSAF EPCHHEVSPT
610 620 630 640 650
PYVKNCRFDV CSSSNGKDSL CSSIANYAAA CARKSILVQW REPDFCPMTC
660 670 680 690 700
PEGQVYQQCG MLCNQTCRSL SYPDEDCDEL CVEGCYCPPG QYLDEHEQCV
710 720 730 740 750
PKSHCSCYYD GEIFQPEDVF SDHYTMCYCE NGFMHCSTNR VPGAFLPDVF
760 770 780 790 800
ADERPSARIK RSLTCRSPME RFVCPANNPR AEGLECAKTC QNYDLECSSH
810 820 830 840 850
GCVSGCLCPR GMVRHENKCV APERCPCFHN GREYAKGETV TNDCNTCVCR
860 870 880 890 900
GRKWECTKNT CDGTCMVIGT AHYLTFDGLK YKFPGNCQYV LVQDFCKNDS
910 920 930 940 950
GTFRILISNE GCGFTGEKCT KRVIILYESG EIELLNGNVN IKVPPKNDND
960 970 980 990 1000
LEVMRSGRYY LIFLGKSISV TWDLAMGVSV ILKGTFKDQV CGLCGNFDGI
1010 1020 1030 1040 1050
QNNDLTSSNE HLEVDPVDFG NSWKVNPYCA DVEKPNLEQT STSPLCNGNI
1060 1070 1080 1090 1100
VKQVMVETSC SILSGNLFEE CKKLVNPEPY IDICMYDTCA CESIGDCACF
1110 1120 1130 1140 1150
CDAIAAYAHV CAQKGVAVRW RSPTLCPQSC EDLNKQELDY QCEWRYNSCG
1160 1170 1180 1190 1200
PACPITCQHL QPLECPLQCV EGCHVHCPAG KILDELSLDC VSPEDCPVCA
1210 1220 1230 1240 1250
VGDVKIPHGK RIVLNRDDPQ RCQSCLCEGN NLTCIACEPV EDTLTVTTPA
1260 1270 1280 1290 1300
PEEDIELPPS EYSCSKMMDL AFLMDGSNKL SEEDFEQLKT FITGMMKKLH
1310 1320 1330 1340 1350
ISQKKIRVSI LVYRAGPTIY LGLKDIKTQS QMRKIVQSIK YTGDEIASAS
1360 1370 1380 1390 1400
EVLKYTVFHV FGKAERTNAA RIAVLFIASK SPGKLRSILT ALKNKKIAVM
1410 1420 1430 1440 1450
AVGIGPYVNA EQIRFIEKQS PDNRAFLMNN VLELMDNRDL LIDRLCDLGP
1460 1470 1480 1490 1500
EESSLVETTS SPTVSSVLFP PWGLTTTTPI SEKPTPKSLD IAFIVEGSDN
1510 1520 1530 1540 1550
VGEENFNIVK KFLEKVITGM NVGQEDIHVT IMQYSETVTL EYSFREIQSK
1560 1570 1580 1590 1600
ENIIEKVRSI PYEGGKATNT GNALNYISKH TFTPMNGGRQ DVPHLVYMVT
1610 1620 1630 1640 1650
SNPSTDVITR HPRSINVIPI GITPNATIQE LRKISQPNNP IILHSYRTLI
1660 1670 1680 1690 1700
EEAPELVLQS CCSRKLWTEI PELCNKPVDV MFLLDGSSNI GASEFEEMKK
1710 1720 1730 1740 1750
FVQAFIESVE ISNTSTHVSV LQYARENNLE ISWNVPQETE KLIEMVQSIQ
1760 1770 1780 1790 1800
QREQGPTRLG KAIDFVVQNA MSESHGGRPS ASKVAVVIVS GRSEDTVEAA
1810 1820 1830 1840 1850
ALSATMNRVS LFPIGVGNLY DEDQLRTLTG PSAANRIMKL QNFEDLSTMI
1860 1870 1880 1890 1900
KLNNEFIKKL CTDPVRECID EEGNKKKPGD KWTLRDQCHT VTCFPGEYTV
1910 1920 1930 1940 1950
LESHQINCER MPKPVCHSNL PAVKIEETCG CRWMCPCVCI GSSSRHIVTF
1960 1970 1980 1990 2000
DGLNFKLTGN CSYTLFRDMQ HDVEVLLHEG PCRATPKMNC MDSIEVKHRG
2010 2020 2030 2040 2050
VSVQLFSDMA VAVNGERVHI PYSSSLFEVN VYGAIMHEIK FSHLGHNLTF
2060 2070 2080 2090 2100
TPRNNEFILK LNSKSFSSGT QGLCGVCDQN HVNDFTLRDG SVTPESSVFI
2110 2120 2130 2140 2150
QNWTVEEPGK ICEIQREDRC SEHATSHCRL LLSDQFAECH RVISPNMFYE
2160 2170 2180 2190 2200
ACAESSCYED EACEMITSYA HICRENGVCI DWRTPEFCPM KCPTYLTYDH
2210 2220 2230 2240 2250
CHKACIKHCE NSTKLSVCKD YPTEGCFCPG GQVIFNDSCV NEEVCTQCIS
2260 2270 2280 2290 2300
EDGTHHQHME TWIPANEPCQ ICTCLDNKKV NCTIRPCPTA KPVQCGPCEV
2310 2320 2330 2340 2350
PRLRRDPGQC CPEYECVCDL VSCDLPPAPA CEFGLQLALT NPGECRPNYT
2360 2370 2380 2390 2400
CACNREACSF LQRPSCPPHR ELTVKKTECC DKYECTCSCT NSTVSCPLGY
2410 2420 2430 2440 2450
LSRSLTNDCG CVSTTCVPGT VCVHNNIVYP IGTTWEDGCR ECSCTSMRDD
2460 2470 2480 2490 2500
VTGLQMMECH DKACNTFCSR GYKYIVEEGE CCGRCQKTAC EEQQFWSRGD
2510 2520 2530 2540 2550
ADPRLHEVGT EWRSPFNRCI INECIQVNNE VFVQQKNLSC SQMDVPDCPE
2560 2570 2580 2590 2600
GTELRCDQII DCCPSCRCVP LNGCLLNGTV IGPWRRLMVD QCTTCVCSFQ
2610 2620 2630 2640 2650
STSSRRYTLT CTKLTCEPCP INYRRQEIPG SCCGKCVPTS CGIRLRDGRL
2660 2670 2680 2690 2700
KYLQPNESLQ DGCDSHSCKV NEKGEFIWER RITGCPPFDS RRCLAEGGRI
2710 2720 2730 2740 2750
AKIGNTCCDT CLEVECRPVS TRLQYPNING CVAEKEVPIS HCEGKCRSNT
2760 2770 2780 2790 2800
RYSVQTGKWE DLCSCCRASQ TTTVTVPLRC ANGTVVQHYI PSASQCECYS

RNCTD
Length:2,805
Mass (Da):312,578
Last modified:November 26, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8ED4A901BE6B546D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KK501303 Genomic DNA Translation: KFP14051.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KK501303 Genomic DNA Translation: KFP14051.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207, Cys_knot_C
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR037578, Von_Willebrand_factor
IPR002035, VWF_A
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR036465, vWFA_dom_sf
PANTHERiPTHR11339:SF361, PTHR11339:SF361, 3 hits
PfamiView protein in Pfam
PF08742, C8, 4 hits
PF01826, TIL, 4 hits
PF00092, VWA, 3 hits
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00327, VWA, 3 hits
SM00214, VWC, 5 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits
SUPFAMiSSF53300, SSF53300, 3 hits
SSF57567, SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS50234, VWFA, 3 hits
PS01208, VWFC_1, 3 hits
PS50184, VWFC_2, 3 hits
PS51233, VWFD, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A091JQY2_EGRGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A091JQY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: June 2, 2021
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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