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Protein

Inhibin alpha chain

Gene

H920_18437

Organism
Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation, HormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chainUniRule annotation
Gene namesi
ORF Names:H920_18437Imported
OrganismiFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)Imported
Taxonomic identifieri885580 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeFukomys
Proteomesi
  • UP000028990 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500187185321 – 367Inhibin alpha chainSequence analysisAdd BLAST347

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 367TGF_BETA_2InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

OMAiFIFHYCH

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A091DBH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNQLPLLLL LLLAPQEGHG CHGMELDREL VLAKVKALFL DALGPPTVTG
60 70 80 90 100
EGEVPGIRRL PRRHTTGDFI RRGSKPEEED VSQAILFPAT GATCEDEAAT
110 120 130 140 150
GVVAPEASEG LFTYVFRPSQ HTRSHQVISA QLWFHTGLDR KVSAASNSSR
160 170 180 190 200
PLLDLLVLSS GGPVAVPMSL GQAPPRWAVL RLATSALPLL THPVLVLLLR
210 220 230 240 250
CPLCSCSARP ETTPFLVAHT RARPPTGGER ARRSTPPMPW PWSPAALRLL
260 270 280 290 300
QRPPEEPTVH AYCHRAALNI SFQELGWDRW IVHPPSFIFH YCHGGCGLPT
310 320 330 340 350
PPDLLQPVPG VPPTSVQPLT LVPGAQPCCA ALLGTMRPLH VRTTSDGGYS
360
FKYETVPNLL TQHCACI
Length:367
Mass (Da):39,793
Last modified:November 26, 2014 - v1
Checksum:i04D822D4F8CFF185
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN124851 Genomic DNA Translation: KFO20151.1
RefSeqiXP_010610118.1, XM_010611816.2

Genome annotation databases

EnsembliENSFDAT00000016345; ENSFDAP00000002541; ENSFDAG00000012220
GeneIDi104853705

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN124851 Genomic DNA Translation: KFO20151.1
RefSeqiXP_010610118.1, XM_010611816.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFDAT00000016345; ENSFDAP00000002541; ENSFDAG00000012220
GeneIDi104853705

Organism-specific databases

CTDi3623

Phylogenomic databases

OMAiFIFHYCH

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A091DBH7_FUKDA
AccessioniPrimary (citable) accession number: A0A091DBH7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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