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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Gene

H920_10188

Organism
Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.UniRule annotation

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation
NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FMNUniRule annotation
  • [4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
Ligand4Fe-4SUniRule annotation, Flavoprotein, FMNUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADUniRule annotation, UbiquinoneImported

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialUniRule annotation (EC:1.6.5.3UniRule annotation, EC:1.6.99.3UniRule annotation)
Gene namesi
ORF Names:H920_10188Imported
OrganismiFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)Imported
Taxonomic identifieri885580 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeFukomys
Proteomesi
  • UP000028990 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini364 – 423NADH_4Fe-4SInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Family and domain databases

Gene3Di1.20.1440.230, 1 hit
3.40.50.11540, 1 hit
InterProiView protein in InterPro
IPR001949 NADH-UbQ_OxRdtase_51kDa_CS
IPR011537 NADH-UbQ_OxRdtase_suF
IPR011538 Nuo51_FMN-bd
IPR037225 Nuo51_FMN-bd_sf
IPR019575 Nuop51_4Fe4S-bd
IPR037207 Nuop51_4Fe4S-bd_sf
IPR019554 Soluble_ligand-bd
PfamiView protein in Pfam
PF01512 Complex1_51K, 1 hit
PF10589 NADH_4Fe-4S, 1 hit
PF10531 SLBB, 1 hit
SMARTiView protein in SMART
SM00928 NADH_4Fe-4S, 1 hit
SUPFAMiSSF140490 SSF140490, 1 hit
SSF142019 SSF142019, 1 hit
TIGRFAMsiTIGR01959 nuoF_fam, 1 hit
PROSITEiView protein in PROSITE
PS00644 COMPLEX1_51K_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A091DB80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVARRLLGG SFPARVSVRF SGDTAAAKKT SFGSLKDEDR IFTNLYGRHD
60 70 80 90 100
WRLKGAQCRG DWYKTKEILL KGPDWILGEI KTSGLRGRGG AGFPTGLKWS
110 120 130 140 150
FMNKPSDGRP KYLVVNADEG EPGTCKDREI MRHDPHKLVE GCLVGGRAMG
160 170 180 190 200
ARAAYIYIRG EFYNEASNLQ VAIREAYEAG LIGKNACGSG YDFDVFVVRG
210 220 230 240 250
AGAYICGEET ALIESIEGKQ GKPRLKPPFP ADVGVFGCPT TVANVETVAV
260 270 280 290 300
SPTICRRGGT WFASFGRERN SGTKLFNISG HVNHPCTVEE EMSVPLKELI
310 320 330 340 350
EKHAGGVTGG WDNLLAVIPG GSSTPLIPKS VCETVLMDFD ALVQAQTGLG
360 370 380 390 400
TAAVIVMDRS TDIVKAIARL IEFYKHESCG QCTPCREAVG DQQSPLAVVA
410 420 430 440 450
TGVDWMNKVM ARFVKGDARP AEIDSLWEIS KQIEGHTICA LGDGAAWPVQ
460 470
GLIRHFRPEL EDRMQRFAQQ HQARQAAS
Length:478
Mass (Da):52,008
Last modified:November 26, 2014 - v1
Checksum:i6F505CB0B7206E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN122776 Genomic DNA Translation: KFO28327.1

Similar proteinsi

Entry informationi

Entry nameiA0A091DB80_FUKDA
AccessioniPrimary (citable) accession number: A0A091DB80
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: March 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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