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Protein
Submitted name:

Ephrin type-A receptor 4

Gene

H920_18433

Organism
Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei740ATPUniRule annotation1
Active sitei833Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi714 – 722ATPUniRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ephrin type-A receptor 4Imported
Gene namesi
ORF Names:H920_18433Imported
OrganismiFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)Imported
Taxonomic identifieri885580 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeFukomys
Proteomesi
  • UP000028990 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei635 – 657HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 296Eph LBDInterPro annotationAdd BLAST180
Domaini415 – 526Fibronectin type-IIIInterPro annotationAdd BLAST112
Domaini527 – 624Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini708 – 969Protein kinaseInterPro annotationAdd BLAST262
Domaini998 – 1062SAMInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd10482 EphR_LBD_A4, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034270 EphA4_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00220 S_TKc, 1 hit
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A091CPY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGRLGASCR SGSRDPDARK TSFVSEPCGG LDVRDVCARA FWRAGGETNT
60 70 80 90 100
PAIKVPPPQS SADGGAPQTP SGAGKRRVAV AARRSECAGC HPSDSRKGAK
110 120 130 140 150
GQSNFVPTAF QVYPANEVTL LDSRSVQGEL GWIASPLEGG WEEVSIMDEK
160 170 180 190 200
NTPIRTYQVC NVMEPSQNNW LRTDWITREG AQRVYIEIKF TLRDCNSLPG
210 220 230 240 250
VMGTCKETFN LYYYESDNDK ERFIRESQFA KIDTIAADES FTQVDIGDRI
260 270 280 290 300
MKLNTEIRDV GPLSKKGFYL AFQDVGACIA LVSVRVFYKK CPLTVRNLAQ
310 320 330 340 350
FPDTITGADT SSLVEVRGSC VNNSEEKDVP KMYCGADGEW LVPIGNCLCN
360 370 380 390 400
AGHEEQNGEC QACKIGYYKA LSTDATCAKC PPHSYSVWEG ATSCTCDRGF
410 420 430 440 450
FRSDNDAASM PCTRPPSAPL NLISNVNETS VNLEWSSPQN TGGRQDISFN
460 470 480 490 500
VVCKKCGAGD PSKCRPCGSG VHYTPQQNGL KTTKVSITDL LAHTNYTFEI
510 520 530 540 550
WAVNGVSKYN PSPDQSVSVT VTTNQAAPSS IALVQAKEVT RYSVALAWLE
560 570 580 590 600
PDRPNGVILE YEVKYYEKDQ NERSYRIVRT AARNTDIKGL NPLTSYVFHV
610 620 630 640 650
RARTAAGYGD FSEPLEVTTN TVPSRIIGDG ANSTVLLVSV SGSVVLVVIL
660 670 680 690 700
IAAFVISRRR SKYSKAKQEA DEEKHLNQGV RTYVDPFTYE DPNQAVREFA
710 720 730 740 750
KEIDASCIKI EKVIGVGEFG EVCSGRLKVP GKREICVAIK TLKAGYTDKQ
760 770 780 790 800
RRDFLSEASI MGQFDHPNII HLEGVVTKCK PVMIITEYME NGSLDAFLRK
810 820 830 840 850
NDGRFTVIQL VGMLRGIGSG MKYLSDMSYV HRDLAARNIL VNSNLVCKVS
860 870 880 890 900
DFGMSRVLED DPEAAYTTRG GKIPIRWTAP EAIAYRKFTS ASDVWSYGIV
910 920 930 940 950
MWEVMSYGER PYWDMSNQDV IKAIEEGYRL PPPMDCPIAL HQLMLDCWQK
960 970 980 990 1000
ERSDRPKFGQ IVNMLDKLIR NPNSLKRTGT ESSRPNTALL DPSSPEFSAV
1010 1020 1030 1040 1050
VSVGDWLQAI KMDRYKDNFT AAGYTTLEAV VHMNQDDLAR IGITAITHQN
1060 1070
KILSSVQAMR TQVQQMHGRM VPV
Length:1,073
Mass (Da):118,600
Last modified:November 26, 2014 - v1
Checksum:i8DBDE02519F4BDF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN124851 Genomic DNA Translation: KFO20147.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN124851 Genomic DNA Translation: KFO20147.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd10482 EphR_LBD_A4, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034270 EphA4_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00220 S_TKc, 1 hit
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A091CPY0_FUKDA
AccessioniPrimary (citable) accession number: A0A091CPY0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: July 18, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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