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1 to 25 of 29  Show
  1. 1
    "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 8216 other entries.

  2. 2
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 722 other entries.

  3. 3
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  4. 4
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  5. 5
    Category: Function, Pathology & Biotech.
    Annotation: role in modulating high-intensity pain stimuliImported.
    Source: GeneRIF:9311.

    This publication is mapped to 4 other entries.

  6. 6
    "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
    Hruska-Hageman A.M., Benson C.J., Leonard A.S., Price M.P., Welsh M.J.
    J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated currentImported.
    Source: GeneRIF:9311.

    This publication is cited by 9 and mapped to 10 other entries.

  7. 7
    Category: Function.
    Annotation: Diclofenac studies show ASIC3 is a significant contributor to cutaneous acid-induced pain.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 12 other entries.

  8. 8
    "Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator."
    Su X., Li Q., Shrestha K., Cormet-Boyaka E., Chen L., Smith P.R., Sorscher E.J., Benos D.J., Matalon S., Ji H.L.
    J. Biol. Chem. 281:36960-36968(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: the interaction of ASIC3 and CFTR may contribute to defective salt and fluid transepithelial transport in the cystic fibrotic pulmonary systemImported.
    Source: GeneRIF:9311.

    This publication is mapped to 70 other entries.

  9. 9
    "Genetic variation in the ASIC3 gene influences blood pressure levels in Taiwanese."
    Ko Y.L., Hsu L.A., Wu S., Teng M.S., Chang H.H., Chen C.C., Cheng C.F.
    J. Hypertens. 26:2154-2160(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator); These results suggest that the ASIC3 may be involved in blood pressure regulation.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  10. 10
    "Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis."
    Yuan F.L., Chen F.H., Lu W.G., Li X.
    Mol. Biol. Rep. 37:3233-3238(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: The biological features of ASIC3 is discussed and recent advances on the role of ASIC3 in the pathogenesis and treatment of arthritis pain are summarized.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  11. 11
    "Association between an ASIC3 gene variant and insulin resistance in Taiwanese."
    Wu S., Hsu L.A., Chou H.H., Teng M.S., Chang H.H., Yeh K.H., Chen C.C., Chang P.Y., Cheng C.F., Ko Y.L.
    Clin. Chim. Acta 411:1132-1136(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: an independent association between an ASIC3 genetic polymorphism and insulin resistance in TaiwaneseImported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  12. 12
    "A role for acid-sensing ion channel 3, but not acid-sensing ion channel 2, in sensing dynamic mechanical stimuli."
    Borzan J., Zhao C., Meyer R.A., Raja S.N.
    Anesthesiology 113:647-654(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Neither ASIC3 or ASIC1 knockout influences the development or maintenance of experimental neuropathic pain after nerve injury.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 6 other entries.

  13. 13
    "Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels."
    Birdsong W.T., Fierro L., Williams F.G., Spelta V., Naves L.A., Knowles M., Marsh-Haffner J., Adelman J.P., Almers W., Elde R.P., McCleskey E.W.
    Neuron 68:739-749(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Used coincidentally by sensory neurons to detect lactic acidosis ASIC3 (amiloride-sensitive cation channel 3) interacts with adenosine triphosphate (ATP) to detect muscle ischemia.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  14. 14
    "Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels."
    Yu Y., Li W.G., Chen Z., Cao H., Yang H., Jiang H., Xu T.L.
    J. Biol. Chem. 286:24996-25006(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  15. 15
    "Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schonlein purpura."
    Yuan L.P., Bo Y., Ming G., Zhou Q.L.
    J. Pediatr. Gastroenterol. Nutr. 54:561-563(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 10 other entries.

  16. 16
    "Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells."
    Khoo S.G., Al-Alawi M., Walsh M.T., Hannigan K., Glynn S., Thornton M., McQuaid S., Wang Y., Hamilton P.W., Verriere V., Gleich G.J., Harvey B.J., Costello R.W., McGarvey L.P.
    Clin. Exp. Allergy 42:1028-1039(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO) acting via ERK1/2 induced the expression of ASIC-3 in epithelial cells.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 4 other entries.

  17. 17
    "ASIC3 channels in multimodal sensory perception."
    Li W.G., Xu T.L.
    ACS Chem Neurosci 2:26-37(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons correlating with their roles in multimodal sensory perception including nociception mechanosensation and chemosensation.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  18. 18
    "Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95."
    Excoffon K.J., Kolawole A.O., Kusama N., Gansemer N.D., Sharma P., Hruska-Hageman A.M., Petroff E., Benson C.J.
    Biochem. Biophys. Res. Commun. 425:13-18(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 12 other entries.

  19. 19
    "Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions."
    Delaunay A., Gasull X., Salinas M., Noel J., Friend V., Lingueglia E., Deval E.
    Proc. Natl. Acad. Sci. U.S.A. 109:13124-13129(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: ASIC3 is able to sense the extracellular pH in both directions and to dynamically adapt its activity between pH 5.0 and 8.0 playing a role in fine tuning neuronal membrane potentials and neuron sensitization in various pH environments.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  20. 20
    "Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers."
    Fromy B., Lingueglia E., Sigaudo-Roussel D., Saumet J.L., Lazdunski M.
    Nat. Med. 18:1205-1207(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 4 other entries.

  21. 21
    Category: Function.
    Annotation: Lignan from thyme possesses inhibitory effect on ASIC3 channel current.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  22. 22
    "Sea anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity."
    Osmakov D.I., Kozlov S.A., Andreev Y.A., Koshelev S.G., Sanamyan N.P., Sanamyan K.E., Dyachenko I.A., Bondarenko D.A., Murashev A.N., Mineev K.S., Arseniev A.S., Grishin E.V.
    J. Biol. Chem. 288:23116-23127(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Sea anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity.Imported.
    Source: GeneRIF:9311.

    This publication is cited by 7 and mapped to 4 other entries.

  23. 23
    "Elevated Expression of Acid-Sensing Ion Channel 3 Inhibits Epilepsy via Activation of Interneurons."
    Cao Q., Wang W., Gu J., Jiang G., Wang K., Xu Z., Li J., Chen G., Wang X.
    Mol. Neurobiol. 53:485-498(2016) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Blocking ASIC3 in interneurons from temporal lobe epilepsy patients decreased the frequency of action potential firing.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 3 other entries.

  24. 24
    "Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder."
    Cho C.H., Lho Y.M., Ha E., Hwang I., Song K.S., Min B.W., Bae K.C., Kim D.H.
    Bone Joint J 97-B:824-829(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: This study suggests that ASIC23may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 10 other entries.

  25. 25
    Category: Function.
    Annotation: These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation as well as on the contribution of those channels to lipid-mediated signaling.Imported.
    Source: GeneRIF:9311.

    This publication is mapped to 5 other entries.

1 to 25 of 29  Show
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