Enhancer of zeste homolog 2 (Drosophila)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin DNA binding Source: Ensembl
• histone-lysine N-methyltransferase activity Source: InterPro
• primary miRNA binding Source: Ensembl
• ribonucleoprotein complex binding Source: Ensembl
• RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
• transcription corepressor activity Source: Ensembl

GO - Biological processⁱ

• cardiac muscle hypertrophy in response to stress Source: Ensembl
• cellular response to hydrogen peroxide Source: Ensembl
• cellular response to trichostatin A Source: Ensembl
• cerebellar cortex development Source: Ensembl
• DNA methylation Source: Ensembl
• G1 to G0 transition Source: Ensembl
• hepatocyte homeostasis Source: Ensembl
• hippocampus development Source: Ensembl
• histone H3-K27 trimethylation Source: Ensembl
• liver regeneration Source: Ensembl
• negative regulation of DNA-binding transcription factor activity Source: Ensembl
• negative regulation of epidermal cell differentiation Source: Ensembl
• negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
• negative regulation of striated muscle cell differentiation Source: Ensembl
• negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
• positive regulation of dendrite development Source: Ensembl
• protein localization to chromatin Source: Ensembl
• regulation of cell population proliferation Source: Ensembl
• regulation of circadian rhythm Source: Ensembl
• regulation of gliogenesis Source: Ensembl
• regulation of protein phosphorylation Source: Ensembl
• response to estradiol Source: Ensembl
• response to tetrachloromethane Source: Ensembl
• skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL 
        60         70         80         90        100
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT 
       110        120        130        140        150
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI 
       160        170        180        190        200
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ 
       210        220        230        240        250
KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ 
       260        270        280        290        300
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHRKC 
       310        320        330        340        350
NYSFHATPNT YKRKNTETAL DNKPCGPQCY QHLEGAKEFA AALTAERIKT 
       360        370        380        390        400
PPKRPGGRRR GRLPNNSSRP STPTINVLES KDTDSDREAG TETGGENNDK 
       410        420        430        440        450
EEEEKKDETS SSSEANSRCQ TPIKMKPNIE PPENVEWSGA EASMFRVLIG 
       460        470        480        490        500
TYYDNFCAIA RLIGTKTCRQ VYEFRVKESS IIAPAPAEDV DTPPRKKKRK 
       510        520        530        540        550
HRLWAAHCRK IQLKKDGSSN HVYNYQPCDH PRQPCDSSCP CVIAQNFCEK 
       560        570        580        590        600
FCQCSSECQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC LTCGAADHWD 
       610        620        630        640        650
SKNVSCKNCS IQRGSKKHLL LAPSDVAGWG IFIKDPVQKN EFISEYCGEI 
       660        670        680        690        700
ISQDEADRRG KVYDKYMCSF LFNLNNDFVV DATRKGNKIR FANHSVNPNC 
       710        720        730        740        750
YAKVMMVNGD HRIGIFAKRA IQTGEELFFD YRYSQADALK YVGIEREMEI 

P                                                      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ