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UniProtKB - A0A090N8E9 (A0A090N8E9_HUMAN)
Protein
Histone-lysine N-methyltransferase EZH2
Gene
EZH2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Catalytic activityi
- L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteineARBA annotationEC:2.1.1.356ARBA annotation
GO - Molecular functioni
- chromatin DNA binding Source: Ensembl
- histone-lysine N-methyltransferase activity Source: InterPro
- primary miRNA binding Source: Ensembl
- ribonucleoprotein complex binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
- transcription corepressor activity Source: Ensembl
GO - Biological processi
- B cell differentiation Source: Ensembl
- cardiac muscle hypertrophy in response to stress Source: Ensembl
- cell development Source: Ensembl
- cellular response to hydrogen peroxide Source: Ensembl
- cellular response to trichostatin A Source: Ensembl
- cerebellar cortex development Source: Ensembl
- chromatin organization Source: UniProtKB-KW
- DNA methylation Source: Ensembl
- G1 to G0 transition Source: Ensembl
- hepatocyte homeostasis Source: Ensembl
- hippocampus development Source: Ensembl
- histone H3-K27 trimethylation Source: Ensembl
- liver regeneration Source: Ensembl
- negative regulation of cytokine production involved in inflammatory response Source: Ensembl
- negative regulation of DNA-binding transcription factor activity Source: Ensembl
- negative regulation of epidermal cell differentiation Source: Ensembl
- negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- negative regulation of striated muscle cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
- positive regulation of dendrite development Source: Ensembl
- protein localization to chromatin Source: Ensembl
- regulation of cell population proliferation Source: Ensembl
- regulation of circadian rhythm Source: Ensembl
- regulation of gliogenesis Source: Ensembl
- regulation of protein phosphorylation Source: Ensembl
- response to estradiol Source: Ensembl
- response to tetrachloromethane Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
- synaptic transmission, GABAergic Source: Ensembl
Keywordsi
Molecular function | Chromatin regulatorARBA annotation, MethyltransferaseARBA annotation, RepressorARBA annotation, Transferase |
Biological process | Biological rhythmsARBA annotation, Transcription, Transcription regulationARBA annotation |
Ligand | S-adenosyl-L-methionineARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase EZH2ARBA annotation (EC:2.1.1.356ARBA annotation) |
Gene namesi | Name:EZH2Imported ORF Names:tcag7.507Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000106462 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- chromatin silencing complex Source: Ensembl
- ESC/E(Z) complex Source: Ensembl
- pronucleus Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
- pericentric heterochromatin Source: Ensembl
- synapse Source: GOC
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000106462, Expressed in bone marrow and 173 other tissues |
ExpressionAtlasi | A0A090N8E9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 508 – 610 | CXCInterPro annotationAdd BLAST | 103 | |
Domaini | 617 – 732 | SETInterPro annotationAdd BLAST | 116 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 180 – 221 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 345 – 431 | DisorderedSequence analysisAdd BLAST | 87 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 180 – 195 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 196 – 220 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 364 – 379 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 380 – 412 | Basic and acidic residuesSequence analysisAdd BLAST | 33 |
Phylogenomic databases
OMAi | CGTECYM |
OrthoDBi | 875190at2759 |
PhylomeDBi | A0A090N8E9 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit cd19218, SET_EZH2, 1 hit |
InterProi | View protein in InterPro IPR026489, CXC_dom IPR045318, EZH1/2-like IPR021654, EZH1/EZH2 IPR044439, EZH2_SET IPR041343, PRC2_HTH_1 IPR041355, Pre-SET_CXC IPR001005, SANT/Myb IPR001214, SET_dom IPR033467, Tesmin/TSO1-like_CXC |
PANTHERi | PTHR45747, PTHR45747, 1 hit |
Pfami | View protein in Pfam PF11616, EZH2_WD-Binding, 1 hit PF18118, PRC2_HTH_1, 1 hit PF18264, preSET_CXC, 1 hit PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM01114, CXC, 1 hit SM00717, SANT, 2 hits SM00317, SET, 1 hit |
PROSITEi | View protein in PROSITE PS51633, CXC, 1 hit PS50280, SET, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A090N8E9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
60 70 80 90 100
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT
110 120 130 140 150
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
160 170 180 190 200
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ
210 220 230 240 250
KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ
260 270 280 290 300
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHRKC
310 320 330 340 350
NYSFHATPNT YKRKNTETAL DNKPCGPQCY QHLEGAKEFA AALTAERIKT
360 370 380 390 400
PPKRPGGRRR GRLPNNSSRP STPTINVLES KDTDSDREAG TETGGENNDK
410 420 430 440 450
EEEEKKDETS SSSEANSRCQ TPIKMKPNIE PPENVEWSGA EASMFRVLIG
460 470 480 490 500
TYYDNFCAIA RLIGTKTCRQ VYEFRVKESS IIAPAPAEDV DTPPRKKKRK
510 520 530 540 550
HRLWAAHCRK IQLKKDGSSN HVYNYQPCDH PRQPCDSSCP CVIAQNFCEK
560 570 580 590 600
FCQCSSECQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC LTCGAADHWD
610 620 630 640 650
SKNVSCKNCS IQRGSKKHLL LAPSDVAGWG IFIKDPVQKN EFISEYCGEI
660 670 680 690 700
ISQDEADRRG KVYDKYMCSF LFNLNNDFVV DATRKGNKIR FANHSVNPNC
710 720 730 740 750
YAKVMMVNGD HRIGIFAKRA IQTGEELFFD YRYSQADALK YVGIEREMEI
P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACC02000041 Genomic DNA Translation: EAL24424.1 |
RefSeqi | NP_004447.2, NM_004456.4 XP_011514186.1, XM_011515884.2 |
Genome annotation databases
GeneIDi | 2146 |
MANE-Selecti | ENST00000320356.7; ENSP00000320147.2; NM_004456.5; NP_004447.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACC02000041 Genomic DNA Translation: EAL24424.1 |
RefSeqi | NP_004447.2, NM_004456.4 XP_011514186.1, XM_011515884.2 |
3D structure databases
SMRi | A0A090N8E9 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A090N8E9 |
Protocols and materials databases
Antibodypediai | 32761, 847 antibodies from 45 providers |
DNASUi | 2146 |
Genome annotation databases
GeneIDi | 2146 |
MANE-Selecti | ENST00000320356.7; ENSP00000320147.2; NM_004456.5; NP_004447.2 |
Organism-specific databases
CTDi | 2146 |
VEuPathDBi | HostDB:ENSG00000106462 |
Phylogenomic databases
OMAi | CGTECYM |
OrthoDBi | 875190at2759 |
PhylomeDBi | A0A090N8E9 |
Miscellaneous databases
BioGRID-ORCSi | 2146, 59 hits in 1062 CRISPR screens |
ChiTaRSi | EZH2, human |
GenomeRNAii | 2146 |
Gene expression databases
Bgeei | ENSG00000106462, Expressed in bone marrow and 173 other tissues |
ExpressionAtlasi | A0A090N8E9, baseline and differential |
Family and domain databases
CDDi | cd00167, SANT, 1 hit cd19218, SET_EZH2, 1 hit |
InterProi | View protein in InterPro IPR026489, CXC_dom IPR045318, EZH1/2-like IPR021654, EZH1/EZH2 IPR044439, EZH2_SET IPR041343, PRC2_HTH_1 IPR041355, Pre-SET_CXC IPR001005, SANT/Myb IPR001214, SET_dom IPR033467, Tesmin/TSO1-like_CXC |
PANTHERi | PTHR45747, PTHR45747, 1 hit |
Pfami | View protein in Pfam PF11616, EZH2_WD-Binding, 1 hit PF18118, PRC2_HTH_1, 1 hit PF18264, preSET_CXC, 1 hit PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM01114, CXC, 1 hit SM00717, SANT, 2 hits SM00317, SET, 1 hit |
PROSITEi | View protein in PROSITE PS51633, CXC, 1 hit PS50280, SET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A090N8E9_HUMAN | |
Accessioni | A0A090N8E9Primary (citable) accession number: A0A090N8E9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 26, 2014 |
Last sequence update: | November 26, 2014 | |
Last modified: | January 19, 2022 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |