UniProtKB - A0A090N7W4 (A0A090N7W4_HUMAN)
Protein
Submitted name:
Cyclin-dependent kinase 5
Gene
CDK5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- acetylcholine receptor activator activity Source: Ensembl
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- cytoskeletal protein binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- ErbB-2 class receptor binding Source: Ensembl
- ErbB-3 class receptor binding Source: Ensembl
- Hsp90 protein binding Source: Ensembl
- p53 binding Source: Ensembl
- protein kinase binding Source: Ensembl
- tau-protein kinase activity Source: Ensembl
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Source: Ensembl
GO - Biological processi
- behavioral response to cocaine Source: Ensembl
- calcium ion import Source: Ensembl
- cell-matrix adhesion Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- central nervous system neuron development Source: Ensembl
- cerebellar cortex formation Source: Ensembl
- corpus callosum development Source: Ensembl
- cortical actin cytoskeleton organization Source: Ensembl
- dendrite morphogenesis Source: Ensembl
- excitatory postsynaptic potential Source: Ensembl
- hippocampus development Source: Ensembl
- histone phosphorylation Source: Ensembl
- intracellular protein transport Source: Ensembl
- layer formation in cerebral cortex Source: Ensembl
- mitochondrion organization Source: Ensembl
- motor neuron axon guidance Source: Ensembl
- negative regulation of axon extension Source: Ensembl
- negative regulation of cell cycle Source: Ensembl
- negative regulation of protein export from nucleus Source: Ensembl
- negative regulation of protein ubiquitination Source: Ensembl
- negative regulation of synaptic plasticity Source: Ensembl
- neuron apoptotic process Source: Ensembl
- neuron migration Source: Ensembl
- nucleocytoplasmic transport Source: Ensembl
- peptidyl-threonine phosphorylation Source: Ensembl
- positive regulation of calcium ion-dependent exocytosis Source: Ensembl
- positive regulation of glial cell apoptotic process Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein kinase activity Source: Ensembl
- positive regulation of protein targeting to membrane Source: Ensembl
- positive regulation of voltage-gated calcium channel activity Source: Ensembl
- protein autophosphorylation Source: Ensembl
- protein localization to synapse Source: Ensembl
- receptor catabolic process Source: Ensembl
- receptor clustering Source: Ensembl
- regulated exocytosis Source: Ensembl
- regulation of cell migration Source: Ensembl
- regulation of dendritic spine morphogenesis Source: Ensembl
- regulation of protein localization to plasma membrane Source: Ensembl
- regulation of synaptic transmission, glutamatergic Source: Ensembl
- response to wounding Source: Ensembl
- Schwann cell development Source: Ensembl
- sensory perception of pain Source: Ensembl
- serine phosphorylation of STAT protein Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- synapse assembly Source: Ensembl
- synaptic transmission, dopaminergic Source: Ensembl
- synaptic transmission, glutamatergic Source: Ensembl
- synaptic vesicle endocytosis Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin-dependent kinase 5ImportedSubmitted name: Cyclin-dependent kinase 5 isoform 1ImportedSubmitted name: Cyclin-dependent kinase 5, isoform CRA_aImportedSubmitted name: Epididymis secretory sperm binding proteinImported |
Gene namesi | Name:CDK5Imported ORF Names:hCG_18690Imported, tcag7.772Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164885.12 |
Subcellular locationi
Cytoskeleton
- microtubule Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- dendrite Source: Ensembl
- filopodium Source: Ensembl
- growth cone Source: Ensembl
- lamellipodium Source: Ensembl
- neuromuscular junction Source: Ensembl
- neuronal cell body Source: Ensembl
- postsynaptic density Source: Ensembl
- presynapse Source: Ensembl
- protein kinase 5 complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000164885, Expressed in prefrontal cortex and 195 other tissues |
Interactioni
GO - Molecular functioni
- cytoskeletal protein binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- ErbB-2 class receptor binding Source: Ensembl
- ErbB-3 class receptor binding Source: Ensembl
- Hsp90 protein binding Source: Ensembl
- p53 binding Source: Ensembl
- protein kinase binding Source: Ensembl
Chemistry databases
BindingDBi | A0A090N7W4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 286 | Protein kinaseInterPro annotationAdd BLAST | 283 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_000288_181_1_1 |
OMAi | KPNFHVY |
OrthoDBi | 1010560at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A090N7W4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR
60 70 80 90 100
EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP
110 120 130 140 150
EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA
160 170 180 190 200
FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR
210 220 230 240 250
PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN
260 270 280 290
VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ900934 mRNA Translation: ADO22451.1 KU177968 mRNA Translation: ALQ33426.1 AACC02000108 Genomic DNA Translation: EAL24498.1 CH471173 Genomic DNA Translation: EAW54049.1 |
RefSeqi | NP_004926.1, NM_004935.3 |
Genome annotation databases
GeneIDi | 1020 |
KEGGi | hsa:1020 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ900934 mRNA Translation: ADO22451.1 KU177968 mRNA Translation: ALQ33426.1 AACC02000108 Genomic DNA Translation: EAL24498.1 CH471173 Genomic DNA Translation: EAW54049.1 |
RefSeqi | NP_004926.1, NM_004935.3 |
3D structure databases
SMRi | A0A090N7W4 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A090N7W4 |
Protocols and materials databases
Antibodypediai | 4556, 982 antibodies |
Genome annotation databases
GeneIDi | 1020 |
KEGGi | hsa:1020 |
Organism-specific databases
CTDi | 1020 |
EuPathDBi | HostDB:ENSG00000164885.12 |
Phylogenomic databases
HOGENOMi | CLU_000288_181_1_1 |
OMAi | KPNFHVY |
OrthoDBi | 1010560at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1020, 13 hits in 880 CRISPR screens |
ChiTaRSi | CDK5, human |
GenomeRNAii | 1020 |
Gene expression databases
Bgeei | ENSG00000164885, Expressed in prefrontal cortex and 195 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A090N7W4_HUMAN | |
Accessioni | A0A090N7W4Primary (citable) accession number: A0A090N7W4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 26, 2014 |
Last sequence update: | November 26, 2014 | |
Last modified: | December 2, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |