CDK5

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	33	ATPPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

acetylcholine receptor activator activity Source: Ensembl
ATP binding Source: UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
cytoskeletal protein binding Source: Ensembl
ephrin receptor binding Source: Ensembl
ErbB-2 class receptor binding Source: Ensembl
ErbB-3 class receptor binding Source: Ensembl
Hsp90 protein binding Source: Ensembl
p53 binding Source: Ensembl
protein kinase binding Source: Ensembl
tau-protein kinase activity Source: Ensembl
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to cocaine Source: Ensembl
calcium ion import Source: Ensembl
cell-matrix adhesion Source: Ensembl
cellular response to amyloid-beta Source: Ensembl
central nervous system neuron development Source: Ensembl
cerebellar cortex formation Source: Ensembl
corpus callosum development Source: Ensembl
cortical actin cytoskeleton organization Source: Ensembl
dendrite morphogenesis Source: Ensembl
excitatory postsynaptic potential Source: Ensembl
hippocampus development Source: Ensembl
histone phosphorylation Source: Ensembl
intracellular protein transport Source: Ensembl
layer formation in cerebral cortex Source: Ensembl
mitochondrion organization Source: Ensembl
motor neuron axon guidance Source: Ensembl
negative regulation of axon extension Source: Ensembl
negative regulation of cell cycle Source: Ensembl
negative regulation of protein export from nucleus Source: Ensembl
negative regulation of protein ubiquitination Source: Ensembl
negative regulation of synaptic plasticity Source: Ensembl
neuron apoptotic process Source: Ensembl
neuron migration Source: Ensembl
nucleocytoplasmic transport Source: Ensembl
peptidyl-threonine phosphorylation Source: Ensembl
positive regulation of calcium ion-dependent exocytosis Source: Ensembl
positive regulation of glial cell apoptotic process Source: Ensembl
positive regulation of neuron apoptotic process Source: Ensembl
positive regulation of protein binding Source: Ensembl
positive regulation of protein kinase activity Source: Ensembl
positive regulation of protein targeting to membrane Source: Ensembl
positive regulation of voltage-gated calcium channel activity Source: Ensembl
protein autophosphorylation Source: Ensembl
protein localization to synapse Source: Ensembl
receptor catabolic process Source: Ensembl
receptor clustering Source: Ensembl
regulated exocytosis Source: Ensembl
regulation of cell migration Source: Ensembl
regulation of dendritic spine morphogenesis Source: Ensembl
regulation of protein localization to plasma membrane Source: Ensembl
regulation of synaptic transmission, glutamatergic Source: Ensembl
response to wounding Source: Ensembl
Schwann cell development Source: Ensembl
sensory perception of pain Source: Ensembl
serine phosphorylation of STAT protein Source: Ensembl
skeletal muscle tissue development Source: Ensembl
synapse assembly Source: Ensembl
synapse pruning Source: Ensembl
synaptic transmission, dopaminergic Source: Ensembl
synaptic transmission, glutamatergic Source: Ensembl
synaptic vesicle endocytosis Source: Ensembl
visual learning Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
Ligand	ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Cyclin-dependent kinase 5Imported Submitted name: Cyclin-dependent kinase 5 isoform 1Imported Submitted name: Cyclin-dependent kinase 5, isoform CRA_aImported Submitted name: Epididymis secretory sperm binding proteinImported
Gene namesⁱ	Name:CDK5Imported ORF Names:hCG_18690Imported, tcag7.772Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

VEuPathDBⁱ	HostDB:ENSG00000164885.12

VEuPathDBⁱ

HostDB:ENSG00000164885.12

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000164885, Expressed in prefrontal cortex and 196 other tissues
ExpressionAtlasⁱ	A0A090N7W4, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

cytoskeletal protein binding Source: Ensembl
ephrin receptor binding Source: Ensembl
ErbB-2 class receptor binding Source: Ensembl
ErbB-3 class receptor binding Source: Ensembl
Hsp90 protein binding Source: Ensembl
p53 binding Source: Ensembl
protein kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	A0A090N7W4

BindingDBⁱ

A0A090N7W4

Structureⁱ

3D structure databases

SMRⁱ	A0A090N7W4
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 286	Protein kinaseInterPro annotationAdd BLAST		283

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	CLU_000288_181_1_1
OMAⁱ	KPNFHVY
Database of Orthologous Groups More...OrthoDBⁱ	1010560at2759

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A090N7W4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR 
        60         70         80         90        100
EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP 
       110        120        130        140        150
EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA 
       160        170        180        190        200
FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR 
       210        220        230        240        250
PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN 
       260        270        280        290 
VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

Length:292

Mass (Da):33,304

Last modified:November 26, 2014 - v1

Checksum:ⁱ54D10495F017D527

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ900934 mRNA Translation: ADO22451.1 KU177968 mRNA Translation: ALQ33426.1 AACC02000108 Genomic DNA Translation: EAL24498.1 CH471173 Genomic DNA Translation: EAW54049.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004926.1, NM_004935.3

Genome annotation databases

GeneIDⁱ	1020
KEGGⁱ	hsa:1020

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A090N7W4	Cyclin-dependent-like kinase 5	)	HUMAN		292	UniRef100_Q00535
Cyclin-dependent kinase 5		PANTR		292
Cyclin-dependent kinase 5 isoform 1		CALJA		292
Cyclin-dependent kinase 5 isoform 1		MACMU		292
Protein kinase domain-containing protein		RHIRO		292
+15

Protein	Similar proteins		Species	Score	Length	Source
A0A090N7W4	Cyclin-dependent-like kinase 5		MOUSE		292	UniRef90_P49615
Cyclin-dependent-like kinase 5		BOVIN		292
Cyclin-dependent-like kinase 5	)	HUMAN		292
Cyclin-dependent kinase 5		PIG		292
Cyclin dependent kinase-5		VICPA		292
+89

Protein	Similar proteins		Species	Score	Length	Source
A0A090N7W4	Cyclin-dependent-like kinase 5		MOUSE		292	UniRef50_P49615
Cyclin-dependent-like kinase 5		BOVIN		292
Cyclin-dependent-like kinase 5	)	HUMAN		292
Cyclin-dependent-like kinase 5		RAT		292
Cyclin-dependent kinase 5		PIG		292
+186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ900934 mRNA Translation: ADO22451.1 KU177968 mRNA Translation: ALQ33426.1 AACC02000108 Genomic DNA Translation: EAL24498.1 CH471173 Genomic DNA Translation: EAW54049.1
RefSeqⁱ	NP_004926.1, NM_004935.3

3D structure databases

SMRⁱ	A0A090N7W4
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	A0A090N7W4

BindingDBⁱ

A0A090N7W4

Protocols and materials databases

Antibodypediaⁱ	4556, 1012 antibodies
The DNASU plasmid repository More...DNASUⁱ	1020

Genome annotation databases

GeneIDⁱ	1020
KEGGⁱ	hsa:1020

Organism-specific databases

CTDⁱ	1020
VEuPathDBⁱ	HostDB:ENSG00000164885.12

Phylogenomic databases

HOGENOMⁱ	CLU_000288_181_1_1
OMAⁱ	KPNFHVY
OrthoDBⁱ	1010560at2759

Miscellaneous databases

BioGRID-ORCSⁱ	1020, 20 hits in 1032 CRISPR screens
ChiTaRSⁱ	CDK5, human
GenomeRNAiⁱ	1020

Gene expression databases

Bgeeⁱ	ENSG00000164885, Expressed in prefrontal cortex and 196 other tissues
ExpressionAtlasⁱ	A0A090N7W4, baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A090N7W4_HUMAN
Accessionⁱ	A0A090N7W4Primary (citable) accession number: A0A090N7W4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 26, 2014
	Last sequence update:	November 26, 2014
	Last modified:	June 2, 2021
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A090N7W4 (A0A090N7W4_HUMAN)

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Cyclin-dependent kinase 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ