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Entry version 32 (10 Apr 2019)
Sequence version 2 (02 Nov 2016)
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Protein

Mycolipanoate synthase

Gene

msl3

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyketide synthase involved in the biosynthesis of methyl-branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of three methylmalonyl (but not malonyl) residues, to form trimethyl-branched fatty-acids.1 Publication

Caution

The previously assigned stop codon (TAA) of pks3 (Rv1180) is found to be a Tyr codon (TAC), and with this change, pks3 and pks4 become a single open reading frame designated msl3.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei178Acyl-thioester intermediate; for beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei626Acyl-ester intermediate; for acyltransferase activityBy similarity1
Active sitei931Proton acceptor; for dehydratase activityBy similarity1
Active sitei1097Proton donor; for dehydratase activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1753 – 1756NADPBy similarity4
Nucleotide bindingi1776 – 1779NADPBy similarity4
Nucleotide bindingi1804 – 1805NADPBy similarity2
Nucleotide bindingi1877 – 1878NADPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • methyl-branched fatty acid biosynthetic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G185E-5349-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00094

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mycolipanoate synthase1 Publication (EC:2.3.1.2521 Publication)
Alternative name(s):
Mycocerosic acid synthase-like polyketide synthase1 Publication
Short name:
MAS-like PKS1 Publication
Mycolipanoic/mycolipenic acids synthase-like polyketide synthasePROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:msl31 Publication
Synonyms:pks3, pks4
Ordered Locus Names:Rv1180/Rv1181Imported
ORF Names:LH57_06485Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1180
Rv1181

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: UniProtKB-SubCell
  • polyketide synthase complex Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells lacking this gene do not produce mycolipanoic acids, mycolipenic (phthienoic) and mycolipodienoic acids, the major constituents of polyacyltrehaloses, but synthesizes all of the other classes of lipids. The absence of the major acyl chains that anchor the surface-exposed acyltrehaloses causes a novel growth morphology.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15PROSITE-ProRule annotationAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043827816 – 2085Mycolipanoate synthaseAdd BLAST2070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi16N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi16S-diacylglycerol cysteinePROSITE-ProRule annotation1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2040O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphopantetheine, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A0A089QRB9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A089QRB9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2005 – 2081CarrierPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni6 – 429Beta-ketoacyl synthase (KS)By similarityAdd BLAST424
Regioni430 – 534Linker domain (LD)By similarityAdd BLAST105
Regioni535 – 834Acyltransferase (AT)By similarityAdd BLAST300
Regioni893 – 1175Dehydratase (DH)By similarityAdd BLAST283
Regioni1211 – 1371Pseudo beta-ketoacyl reductase (PsiKR)By similarityAdd BLAST161
Regioni1399 – 1723Enoylreductase (ER)By similarityAdd BLAST325
Regioni1745 – 1984Beta-ketoacyl reductase (KR)By similarityAdd BLAST240

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG3321 LUCA

KEGG Orthology (KO)

More...
KOi
K12432

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0A089QRB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTATATSVA VIGMACRLPG GIDSPQRLWE ALLRGDDLVG EIPADRWDAN
60 70 80 90 100
VYYDPEPGVP GRSVSRWGAF LDDVGGFDCD FFGLTEREAT AIDPQHRLLL
110 120 130 140 150
EVSWEAIEHA GVDPATLAES QTGVFVGLTH GDYELLSADC GAAEGPYGFT
160 170 180 190 200
GTSNSFASGR VAYTLGLHGP AVTVDTACSS GLTAVHQACR SLDDGESDLA
210 220 230 240 250
LAGGVVVTLE PRKSVSGSLQ GMLSPTGRCH AFDEAADGFV SGEGCVVLLL
260 270 280 290 300
KRLPDAVRDG DRVLAIVRGT AANQDGRTVN IAAPSAQAQI AVYQQALAAA
310 320 330 340 350
GVEASTVGMV EAHGTGTPVG DPVEYASLAA VYGTEGPCAL TSVKTNFGHL
360 370 380 390 400
QSASGPLGLM KTILALRHGV VPQNLHFCRL PDQLAEIDTE LFVPQANTSW
410 420 430 440 450
PDNTGQPRRA AVSSYGMSGT NVHAILEQAP VSEPAASGPE LTPEAGGLAL
460 470 480 490 500
FPVSATSAEQ LHVTAARLAD WVDQNGNAGS RVSMRDLGYT LSCRRAHRPV
510 520 530 540 550
RTVVTASSFD ELSAALRDVA GDQIPYQPAV GHDDRGPVWV FSGQGSQWPG
560 570 580 590 600
MGTELLVAEP VFAATVAAME PVIARESGFS VTEAMSAPQT VSGIDRVQPT
610 620 630 640 650
IFAVQVALAA ALKSYGVRPG AIIGHSLGEA AAAVVAGALS LHDGLRVICR
660 670 680 690 700
RSRLMSRIAG SGAMASVELP GQQVLSELAI RGISDVVLSV VASPTSTVVG
710 720 730 740 750
GATQSIRDLV AAWEQQDVLA REVAVDVASH TPQVDPILDE LLEVLAEVDP
760 770 780 790 800
TAPEIPYYSA TLWDPRERPS FTGEYWVENL RYTVRFAAAV QAALKDGYRV
810 820 830 840 850
FGELAPHPLL TYAVEQNAAS LDMPIATLAA MRRGEQLPFG LRGFVADVHN
860 870 880 890 900
AGAKVDFSVQ YPDGRLVDAP LPSWTHRTLM LSREDSHRSH TGAVQAVHPL
910 920 930 940 950
LGAHVHLLEE PERHVWQAGV GTGAHPWLGD HRIHNVAAFP GAAYCEMALA
960 970 980 990 1000
AARTTLGELS EVRDIKFEQT LLLDEQTVVS SAATIAAPGI LQFAVESHQE
1010 1020 1030 1040 1050
GEPARRASAM LHALEEMPQP PGYDTNALTA AHESSMSGEE LRKMFNSLGI
1060 1070 1080 1090 1100
QYGPAFSGLV AVHTARGDVT TVLAEVALPG AIRSQQSAYA SHPALLDACF
1110 1120 1130 1140 1150
QSVLVHPEVQ KATVGGLMLP VGVRRLRNYH STRSAHYCLA RVTSSSRAGE
1160 1170 1180 1190 1200
CEADLDVFDQ AGTVLLTVEG LRLAAGISEH ERANRVFDER LLTIEWERGE
1210 1220 1230 1240 1250
LPEVPQIDAG SWLLLSASEA DPLTAQLADA LNAVGAQSTS VASASDVAQL
1260 1270 1280 1290 1300
RSLLGGRLTG VVVVTGPPTG GLTQCGRDYV SQLVGIAREL AELPGEPPRL
1310 1320 1330 1340 1350
FVVTRSAASV LPSDLANLEQ AGLRGLMRVI DSEHPHLGAT AIDVDNDETV
1360 1370 1380 1390 1400
AALVASQLQS GSQEDETAWR NGIWYTARLR PGPLRPAERR TAVVEYRRDG
1410 1420 1430 1440 1450
MRLQIRTPGD LESLEFVTFD RVAPGPGEIE VAVTASSVNF ADVLVAFGRY
1460 1470 1480 1490 1500
PTFEGYRQQL GIDFAGVVTA VGPDVTEHRI GDHVGGMSAN GCWSTFVRCD
1510 1520 1530 1540 1550
ARLAVTLPPE LPVAAAAAVP TASATAWYAL HDLARICSDD KVLIHSGTGG
1560 1570 1580 1590 1600
VGQAAIAIAR AAGCEIFATA GSAQRRQLLH DMGVEHVYDS RSTEFAEQIR
1610 1620 1630 1640 1650
GDTDGYGVDV VLNSLPGAAQ RAGIELLAFG GRFVEIGKRD IYGDTRLGLF
1660 1670 1680 1690 1700
PFRRNLSLYA VDLALLTHSH PHTVRRLLKT VYQHTVEGTL PVPQTTHYPI
1710 1720 1730 1740 1750
HDAAVAIRLV GGAGHTGKVV LDVPRTGEGV AVVPPEQVRT SRPDGAYLVT
1760 1770 1780 1790 1800
GGLGGLGLFL AGELAAAGCG RIVLNSRSTP SPHATRVIER LRAAGADIQV
1810 1820 1830 1840 1850
ECGDIADAAT AHRVVAVATA SGLPVRGVLH AAAVVEDATL ANVTDELIDR
1860 1870 1880 1890 1900
CWAPKVHGAW NIHRATAAQP LEWFCLFSSA AALVGSPGQG AYAAANSWLD
1910 1920 1930 1940 1950
AFAHWRRAQG LPATSIAWGA WAEIGRATAL AEGTGAAIAP AEGARAFQTL
1960 1970 1980 1990 2000
LRYGRAYSGY APIMGTPWLT AFAQRSRFAE AFHATGQNQP ATGKFLAELG
2010 2020 2030 2040 2050
SLPREEWPRT VRRLVSDQIS LLLRRTIDPD RPLSDYGLDS LGNLELRTRI
2060 2070 2080
ETETGIRVSP TKITTVRGLA EHVCDELAAA QSAPV
Length:2,085
Mass (Da):220,462
Last modified:November 2, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13B171F97272F48A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AIR13928 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CCP43936 differs from that shown. Reason: Erroneous gene model prediction. Rv1180 and Rv1181 have been merged into one gene.1 Publication
The sequence CCP43937 differs from that shown. Reason: Erroneous gene model prediction. Rv1180 and Rv1181 have been merged into one gene.1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43936.1 Sequence problems.
AL123456 Genomic DNA Translation: CCP43937.1 Sequence problems.
CP009480 Genomic DNA Translation: AIR13928.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_215696.1, NC_000962.3
NP_215697.1, NC_000962.3
WP_003406192.1, NZ_NVQJ01000025.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AIR13928; AIR13928; LH57_06485
CCP43936; CCP43936; Rv1180
CCP43937; CCP43937; Rv1181

Database of genes from NCBI RefSeq genomes

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GeneIDi
886055
886081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1180
mtu:Rv1181
mtv:RVBD_1181

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.111.peg.1321

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP43936.1 Sequence problems.
AL123456 Genomic DNA Translation: CCP43937.1 Sequence problems.
CP009480 Genomic DNA Translation: AIR13928.1 Different initiation.
RefSeqiNP_215696.1, NC_000962.3
NP_215697.1, NC_000962.3
WP_003406192.1, NZ_NVQJ01000025.1

3D structure databases

ProteinModelPortaliA0A089QRB9
SMRiA0A089QRB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1181

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13928; AIR13928; LH57_06485
CCP43936; CCP43936; Rv1180
CCP43937; CCP43937; Rv1181
GeneIDi886055
886081
KEGGimtu:Rv1180
mtu:Rv1181
mtv:RVBD_1181
PATRICifig|83332.111.peg.1321

Organism-specific databases

TubercuListiRv1180
Rv1181

Phylogenomic databases

eggNOGiCOG3321 LUCA
KOiK12432

Enzyme and pathway databases

UniPathwayi
UPA00094

BioCyciMetaCyc:G185E-5349-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSL3_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A089QRB9
Secondary accession number(s): L0T5X5, L0T647
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: November 2, 2016
Last modified: April 10, 2019
This is version 32 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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