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Entry version 29 (02 Dec 2020)
Sequence version 2 (22 Nov 2017)
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Protein

IQCJ-SCHIP1 readthrough transcript protein

Gene

Iqcj-Schip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25953347, PubMed:25950943, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IQCJ-SCHIP1 readthrough transcript proteinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Iqcj-Schip1By similarity
Synonyms:IqschfpImported, Schip1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:5439400, Iqschfp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking all isoforms encoded by both Schip1 and Iqcj-Schip1 are fertile and survive as long as wild-type mice. However, they exhibit mild growth delay associated with ataxia and reduced pain sensitivity. They display decreased thickness of the piriform cortex and partial agenesis of the anterior comissure which could be due to impaired axon elongation and guidance. The morphology of nodes of Ranvier is affected but nerves do not exhibit significant electrophysiological characteristic differences. A reduction in the number of axonal projections in the peripheral nerve system is also observed.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi53 – 54IQ → AA: Loss of interaction with calmodulin. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004423331 – 559IQCJ-SCHIP1 readthrough transcript proteinAdd BLAST559

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (via coiled coil domain) (PubMed:27979964).

Interacts (via IQ domain) with calmodulin; the interaction is direct and lost in presence of calcium (PubMed:18550753).

Interacts with ANK3 (via ANK repeats); required for its localization at axon initial segments (AIS) and nodes of Ranvier (PubMed:18550753).

Interacts with SPTBN4 (PubMed:27979964).

Interacts with KCNQ2 and KCNQ3 (PubMed:27979964).

2 Publications

GO - Molecular functioni

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A0A088MLT8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A088MLT8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 67IQAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni415 – 559Required for interaction with ankyrins1 PublicationAdd BLAST145

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili496 – 530Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 142Ser-richPROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011127

Identification of Orthologs from Complete Genome Data

More...
OMAi
XLQSGMN

Database of Orthologous Groups

More...
OrthoDBi
1290403at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029362, IQCJ-SCHIP1_N
IPR039045, SCHIP_1
IPR015649, SCHIP_1_C

The PANTHER Classification System

More...
PANTHERi
PTHR13103, PTHR13103, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15157, IQCJ-SCHIP1, 1 hit
PF10148, SCHIP-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Iqcj-schip1-1 (identifier: A0A088MLT8-1) [UniParc]FASTAAdd to basket
Also known as: IQCJ-SCHIP-11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLEELKRLQ NPLEQVDDGK YLLENHQLAM DVENNIENYP LSLQPLESKV
60 70 80 90 100
KIIQRAWREY LQRQDPLEKR SPSPPSVSSD KLSSSVSMNT FSDSSTPDYR
110 120 130 140 150
EDGMDLGSDA GSSSSSRASS QSNSTKVTPC SECKSSSSPG GSLDLVSALE
160 170 180 190 200
DYEEPFPVYQ KKVIDEWAPE EDGEEEEEED DRGYRDDGCP AREPGDVSAR
210 220 230 240 250
IGSSGSGSRS AATTMPSPMP NGNLHPHDPQ DLRHNGNVVV AGRPNASRVP
260 270 280 290 300
RRPIQKTQPP GSRRGGRNRA SGGLCLQPPD GGTRVPEEPP APPMDWEALE
310 320 330 340 350
KHLAGLQFRE QEVRNQGQAR TNSTSAQKNE RESIRQKLAL GSFFDDGPGI
360 370 380 390 400
YTSCSKSGKP SLSARLQSGM NLQICFVNDS GSDKDSDADD SKTETSLDTP
410 420 430 440 450
LSPMSKQSSS YSDRDTTEEE SESLDDMDFL TRQKKLQAEA KMALAMAKPM
460 470 480 490 500
AKMQVEVEKQ NRKKSPVADL LPHMPHISEC LMKRSLKPTD LRDMTIGQLQ
510 520 530 540 550
VIVNDLHSQI ESLNEELVQL LLIRDELHTE QDAMLVDIED LTRHAESQQK

HMAEKMPAK
Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.1 Publication
Length:559
Mass (Da):61,917
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72C5FB63AD80036D
GO
Isoform Iqcj-schip1-2 (identifier: A0A088MLT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-325: Missing.

Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.1 Publication
Show »
Length:331
Mass (Da):37,467
Checksum:iE80C3EAF5B134788
GO
Isoform Iqcj-1 (identifier: Q8BPW0-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8BPW0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:110
Mass (Da):12,662
GO
Isoform Schip1-1 (identifier: P0DPB4-1) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Schip-1a
The sequence of this isoform can be found in the external entry P0DPB4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:484
Mass (Da):53,306
GO
Isoform Schip1-2 (identifier: P0DPB4-2) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DPB4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:456
Mass (Da):49,983
GO
Isoform Schip1-3 (identifier: P0DPB4-3) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DPB4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:244
Mass (Da):27,490
GO
Isoform Schip1-4 (identifier: P0DPB4-4) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Schip-1b
The sequence of this isoform can be found in the external entry P0DPB4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:256
Mass (Da):28,857
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05922698 – 325Missing in isoform Iqcj-schip1-2. Add BLAST228

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU163409 mRNA Translation: ABW06762.1
KJ941154 mRNA Translation: AIN40496.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS79923.1 [A0A088MLT8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001106890.1, NM_001113419.2 [A0A088MLT8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000182006; ENSMUSP00000138212; ENSMUSG00000102422 [A0A088MLT8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100505386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100505386

UCSC genome browser

More...
UCSCi
uc056zsu.1, mouse [A0A088MLT8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU163409 mRNA Translation: ABW06762.1
KJ941154 mRNA Translation: AIN40496.1
CCDSiCCDS79923.1 [A0A088MLT8-1]
RefSeqiNP_001106890.1, NM_001113419.2 [A0A088MLT8-1]

3D structure databases

SMRiA0A088MLT8
ModBaseiSearch...

Genome annotation databases

EnsembliENSMUST00000182006; ENSMUSP00000138212; ENSMUSG00000102422 [A0A088MLT8-1]
GeneIDi100505386
KEGGimmu:100505386
UCSCiuc056zsu.1, mouse [A0A088MLT8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100505386
MGIiMGI:5439400, Iqschfp

Phylogenomic databases

GeneTreeiENSGT00390000011127
OMAiXLQSGMN
OrthoDBi1290403at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gm21949, mouse

Protein Ontology

More...
PROi
PR:A0A088MLT8
RNActiA0A088MLT8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR029362, IQCJ-SCHIP1_N
IPR039045, SCHIP_1
IPR015649, SCHIP_1_C
PANTHERiPTHR13103, PTHR13103, 1 hit
PfamiView protein in Pfam
PF15157, IQCJ-SCHIP1, 1 hit
PF10148, SCHIP-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQIP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A088MLT8
Secondary accession number(s): A8IJC6
, A8IJD0, A8IJD3, F6YL02, F8WI70, Q3TI53, Q52KH1, Q6P9Y8, Q9CX07, Q9JLR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 22, 2017
Last modified: December 2, 2020
This is version 29 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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