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Protein

Ice-structuring protein

Gene

AFPIII-26

Organism
Lycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lowers the blood freezing point. Contributes to protect fish blood from freezing at subzero sea water temperatures. Binds to nascent ice crystals and prevents further growth.UniRule annotation

Keywordsi

Molecular functionAntifreeze proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring proteinUniRule annotation
Alternative name(s):
Antifreeze proteinUniRule annotation
Gene namesi
Name:AFPIII-26Imported
OrganismiLycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)Imported
Taxonomic identifieri8201 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesZoarcidaeLycodinaeLycodichthys

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60AFP-likeInterPro annotationAdd BLAST60
Domaini71 – 130AFP-likeInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the type-III AFP family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR006013 Antifreeze_III
IPR013974 SAF
PRINTSiPR00357 ANTIFREEZIII
SMARTiView protein in SMART
SM00858 SAF, 2 hits
SUPFAMiSSF51269 SSF51269, 2 hits
PROSITEiView protein in PROSITE
PS50844 AFP_LIKE, 2 hits

Sequencei

Sequence statusi: Fragment.

A0A088AZR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SVVANQLIPI NTALTLVMMK AEEVSPKGIP AEEIPKLVGM QVNRAVYLDQ
60 70 80 90 100
TLMPDMVKNY EDGTTCPGIK SVVANQLIPI NTALTLVMMK AEEVSPKGIP
110 120 130 140
AEEIPKLVGM QVNRAVYLDQ TLMPDMVKNY EDGTTCPGIK
Length:140
Mass (Da):15,214
Last modified:November 26, 2014 - v1
Checksum:i70FCC1888B45EC10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei140Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX844827 Genomic DNA Translation: AFU88742.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX844827 Genomic DNA Translation: AFU88742.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR006013 Antifreeze_III
IPR013974 SAF
PRINTSiPR00357 ANTIFREEZIII
SMARTiView protein in SMART
SM00858 SAF, 2 hits
SUPFAMiSSF51269 SSF51269, 2 hits
PROSITEiView protein in PROSITE
PS50844 AFP_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A088AZR0_LYCDA
AccessioniPrimary (citable) accession number: A0A088AZR0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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